3-Bromopyridine-4-carboxylic acid methyl ester

Methyl 3-bromopyridine-4-carboxylate is one of the organic compounds. Its physical properties are quite unique, and are described in detail below.
This substance is usually in a solid state under normal temperature and pressure. Looking at its appearance, it is mostly white to off-white crystalline powder with fine texture and a uniform state as far as the eye can see.
When it comes to melting point, it is about within a specific temperature range. The determination of melting point is crucial for identification and purity determination. Due to the different purity of this compound, the melting point may vary. Its specific melting point value is determined by factors such as intermolecular forces and crystal structure. The stronger the intermolecular force, the more regular the crystal structure and the higher the melting point.
In terms of solubility, it shows certain solubility characteristics in common organic solvents. For example, in some polar organic solvents such as methanol and ethanol, there is a certain solubility. Due to the molecular structure, both polar pyridine rings and carboxyl methyl ester groups can form hydrogen bonds or other intermolecular forces with polar solvents, so they can be dissolved. However, in non-polar solvents such as n-hexane, the solubility is very small. Due to the weak intermolecular force between non-polar solvents and the compound, it is difficult to overcome the interaction between the compound molecules and make it disperse in the solvent.
In addition, its density is also an important physical property. The size of the density is related to the mass of the molecule and the way the molecule is packed. The larger the molecular mass, the more tightly packed, and the higher the density. Although the exact density value needs to be determined by precise experiments, its density characteristics have certain guiding significance in practical applications such as separation and purification.
Its stability at room temperature is acceptable, and it may be exposed to extreme conditions such as hot topics, open flames, or chemical reactions, resulting in structural changes. And in a specific pH environment, it may also participate in the reaction, which is related to the chemical activity of bromine atoms, pyridine rings and carboxyl methyl esters in the molecule.

Methyl 3-bromopyridine-4-carboxylate, this compound has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. The special structure of the gainpyridine ring with bromine atoms and ester groups endows it with unique reactivity and can participate in a variety of organic reactions to construct complex molecular structures with biological activities, which in turn lays the foundation for the creation of new drugs. For example, when developing targeted drugs for specific diseases, its structure can be modified through a series of reactions to achieve the expected pharmacological efficacy.
In the field of materials science, it also has important applications. Due to its structural properties, polymer materials can be introduced through specific chemical reactions to change the electrical, optical or mechanical properties of the materials. For example, connecting it to the polymer backbone is expected to improve the conductivity or fluorescence properties of the material, and show potential value in organic optoelectronic materials.
In addition, in the study of organic synthesis chemistry, 3-bromopyridine-4-carboxylic acid methyl ester is a commonly used starting material. Chemists use selective reactions on their bromine atoms and ester groups, such as nucleophilic substitution, esterification, hydrolysis, etc., to expand the diversity of molecular structures, explore novel organic synthesis paths and methods, and contribute to the development of organic chemistry.

The method of preparing methyl 3-bromopyridine-4-carboxylic acid has been investigated by Sanda in the past, but the method of Chen number is below.
First, 3-bromopyridine-4-carboxylic acid is used as the starting material. This acid is mixed with methanol, an appropriate amount of concentrated sulfuric acid is added as a catalyst, and the reaction is refluxed under heat. Concentrated sulfuric acid can promote the esterification reaction of carboxylic acid and alcohol, so that the two condensate to form esters. After the reaction is completed, the system is cooled, poured into ice water, and the product is extracted with an organic solvent. The extract is dried with anhydrous sodium sulfate, and the solvent is removed by rotary evaporation. Methyl 3-bromopyridine-4-
Second, first convert 3-bromopyridine-4-carboxylic acid into acyl chloride. Oxalyl chloride or dichlorosulfoxide react with 3-bromopyridine-4-carboxylic acid, which can react with carboxylic acid to convert carboxylic group into acyl chloride to generate 3-bromopyridine-4-formyl chloride. In the reaction, a small amount of N, N-dimethylformamide (DMF) may be added as a catalyst to accelerate the reaction process. Then, the resulting acid chloride is dropped into the mixture of methanol and acid binding agent (such as triethylamine). The acid chloride reacts with methanol. The acid binding agent can neutralize the hydrogen chloride generated by the reaction and promote the reaction to proceed forward. The final product is 3-bromopyridine-4-carboxylic acid methyl ester.
Third, suitable pyridine derivatives can be used. If there is a pyridine containing a suitable substituent, the bromine atom is introduced at the 3rd position through the halogenation reaction, and then the carboxylation reaction is introduced at the 4th position. Then the esterification is carried out as before, and the 3-bromopyridine-4-carboxylic acid methyl ester can also be obtained. During halogenation, suitable halogenating reagents and reaction conditions can be selected according to the specific substrate and reaction conditions; carboxylation reactions may require the participation of transition metal catalysts to achieve precise functional group transformation.

Methyl 3-bromopyridine-4-carboxylate is an organic compound, and many matters need to be taken into account during storage.
First, pay attention to the temperature and humidity of the storage environment. This compound is mostly sensitive to changes in temperature and humidity, and high temperature can easily cause its chemical properties to change, or cause reactions such as decomposition; too high humidity, or make the compound damp, affecting its purity and quality. Therefore, it should be stored in a cool and dry place. Generally, the temperature can be controlled below 20 ° C, and the relative humidity should be between 40% and 60%.
Second, the storage place should be well ventilated. Because it may have a certain volatile and irritating odor, poor ventilation, odor accumulation, not only endangers the health of the storage, but also may cause safety hazards due to high gas concentration.
Third, pay attention to its isolation from other substances. Methyl 3-bromopyridine-4-carboxylate has specific chemical activity, contact with oxidants, reducing agents, acids, alkalis and other substances, or chemical reactions occur. In case of strong oxidants, or cause severe oxidation reactions, and even cause serious consequences such as combustion and explosion. When storing, be sure to separate from such substances and set clear labels to prevent mismixing.
Fourth, packaging is also crucial. Packing materials with good sealing performance should be used, such as glass bottles, plastic bottles, etc., and make sure that the caps are tightened to prevent compound volatilization and leakage. If the packaging is damaged, the packaging should be replaced in time and re-sealed to ensure safe storage.
In short, the storage of 3-bromopyridine-4-carboxylic acid methyl ester requires careful attention to temperature and humidity, ventilation, material isolation and packaging to ensure its quality and storage safety.

I think what you are asking is about the market price range of 3 - Bromopyridine - 4 - carboxylic acid methyl ester. However, the price of this chemical is difficult to determine, and it is subject to many factors.
First, the cost of raw materials is the key. If the price of starting materials and reagents required for the synthesis of this substance fluctuates, the final selling price will also be affected. For raw materials such as bromine and pyridine derivatives, if the supply shortage or market demand greatly increases the price, the cost of 3 - Bromopyridine - 4 - carboxylic acid methyl ester will rise, and the price will rise accordingly.
Second, the production process and scale are related to the price. An efficient and mature production process can reduce production costs. If it is produced on a large scale, the unit cost will also be reduced due to the scale effect, and the selling price may be more affordable. On the contrary, if the process is complex and the production scale is small, the cost will be high and the price will not be low.
Third, the market supply and demand situation determines the price. If the market has strong demand for this chemical and the supply is limited, the price will rise; if the market supply exceeds the demand, the merchant may reduce the price to reduce the inventory.
Fourth, regional differences cannot be ignored. In different places, prices may vary due to different transportation costs, tax policies, and the degree of competition in the local market. In places with convenient transportation and developed chemical industry, the price may be relatively low; while in remote places with scarce chemical resources, the price may be higher due to the superposition of transportation and other costs.
To sum up, in order to know the exact market price range, it is necessary to consider the above factors in detail, and it is advisable to consult chemical product suppliers, distributors, or refer to the quotations of relevant chemical product trading platforms in order to obtain a more accurate price range.