3-bromo-6-methylpyridine-2-carbonitrile

3-Bromo-6-methylpyridine-2-carbonitrile is a crucial compound in the field of organic synthesis. It has a wide range of uses and is first introduced in the field of medicinal chemistry. In this field, it is often a key intermediate, helping to create various drug molecules. The combination of the specific structure of the Geynepyridine ring and cyano and bromine atoms endows the compound with unique reactivity and biological activity. It can be seen in the synthesis of many antibacterial, anti-inflammatory and anti-tumor drugs. Medicinal chemists modify and modify its structure by introducing different functional groups to optimize the efficacy, selectivity and pharmacokinetic properties of the drug.
Furthermore, in the field of materials science, 3-bromo-6-methylpyridine-2-carbonitrile also has outstanding performance. It can be used to prepare organic materials with special photoelectric properties. For example, in the synthesis of organic Light Emitting Diode (OLED) materials, it can participate in the construction of conjugated systems, which affects the luminous efficiency and color of materials. Because of its structure, it can be precisely adjusted, so the material properties can be customized according to specific needs to meet the requirements of high-performance organic materials in display technology and other fields.
In addition, in the field of pesticide chemistry, this compound also plays an important role. As an important raw material for the synthesis of new pesticides, pesticide varieties with high insecticidal, bactericidal or herbicidal activities can be derived. Using its special structure and reactivity, compounds with high affinity to specific targets in pests or weeds can be designed and synthesized to achieve precise and efficient control effects while reducing environmental impact.
In summary, 3-bromo-6-methylpyridine-2-carbonitrile plays an indispensable role in many fields such as drugs, materials and pesticides due to its unique chemical structure, providing important material basis and technical support for the development of various fields.

The synthesis method of 3-bromo-6-methylpyridine-2-formonitrile can be obtained from many ways. One method is to take 6-methylpyridine-2-formonitrile as the base and make it react with the brominating agent. If liquid bromine is used as the brominating agent, in an appropriate solvent, accompanied by a catalyst, such as iron powder or iron tribromide, the temperature control reaction. The nitrogen atom on the Gein pyridine ring has electron-absorbing properties, which decreases the electron cloud density of the ortho and para-position. However, the 3-position of 6-methyl pyridine-2-formonitrile is affected by the comprehensive electronic effect of methyl and formonitrile groups, and the electron cloud density is relatively suitable for bromination reactions.
Another method is to prepare pyridine derivatives containing bromine and methyl first, and then introduce formonitrile groups. For example, 3-bromo-6-methyl pyridine is obtained first, and then cyanide is used. The cyanidation method can make cyanide reagents such as 3-bromo-6-methylpyridine and cuprous cyanide react in an organic solvent at a suitable temperature and pressure. This reaction requires attention to the proportion of reagents and the control of reaction conditions, so as to increase the yield and reduce the side reactions.
Furthermore, a series of reaction steps can be designed, starting from the basic raw materials, and gradually constructing the target molecule. For example, suitable hydrocarbons, nitrogen-containing compounds, etc. are used as starting materials, and they are obtained through a series of reactions such as cyclization and substitution. Although this approach is cumbersome, it can be flexibly adjusted according to the convenience of raw materials and the benefits of reaction conditions. Each method has its advantages and disadvantages. When actually synthesizing, it should be carefully selected according to the availability of raw materials, cost considerations, yield and purity.

3-Bromo-6-methylpyridine-2-carbonitrile is an organic compound. Its physical properties are crucial to the performance of this compound in various chemical processes and applications.
First appearance, this compound is often white to light yellow solid. This appearance feature can help chemists visually determine its purity and state.
When it comes to melting point, the melting point of this compound is in a specific temperature range. Accurate melting point values are of great significance for the identification and purification of this compound. By measuring the melting point, the purity of the compound can be determined. If the purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point is reduced and the range is wider.
Boiling point is also an important physical property. Knowing the boiling point, in separation and purification operations such as distillation, appropriate temperature conditions can be set to achieve effective separation of this compound from other substances.
In terms of solubility, 3-bromo-6-methylpyridine-2-carbonitrile exhibits different solubility in organic solvents such as dichloromethane, chloroform, and ethanol. In dichloromethane and chloroform, its solubility is usually quite good, but in ethanol, its solubility may be affected by factors such as temperature. In water, the solubility of this compound is relatively low, because its molecular structure has fewer hydrophilic groups and more hydrophobic parts.
Density is also a physical property that cannot be ignored. Accurate density data is indispensable in chemical experiments and industrial production involving mass and volume conversion, which can ensure accurate feeding, thereby ensuring the smooth progress of the reaction and the stability of the product quality.
In addition, the stability of this compound is also related to its physical properties. Under normal storage and use conditions, it has certain stability, but under specific conditions such as high temperature, strong oxidizing agent, or chemical reactions occur, resulting in changes in its structure and properties. The physical properties of 3-bromo-6-methylpyridine-2-carbonitrile, such as its appearance, melting point, boiling point, solubility, density and stability, are of great guiding value for its synthesis, separation, purification and practical application, and lay the foundation for the rational use of this compound by chemists.

3-Bromo-6-methylpyridine-2-carbonitrile is an organic compound with unique chemical properties. It contains bromine atoms, which cause it to have the characteristics of halogenated hydrocarbons and can undergo nucleophilic substitution reactions. In the presence of appropriate nucleophilic reagents, such as alkoxides and amines, bromine atoms are easily replaced by nucleophilic reagents to form new derivatives. This reaction can expand its chemical structure and synthesize a variety of organic compounds.
And because of its cyanyl group, it has the properties of nitrile compounds. Cyanyl groups can be hydrolyzed and converted into carboxylic groups under the catalysis of acids or bases to form 3-bromo-6-methylpyridine-2-carboxylic acid. This reaction can be used to construct carboxylic-containing structures in organic synthesis, providing key intermediates for the preparation of drugs and materials.
At the same time, cyanyl groups can also be reduced. For example, strong reducing agents such as lithium aluminum hydride can reduce cyanyl groups to aminomethyl groups to obtain 3-bromo-6-methylpyridine-2-methanamine, providing a way for the introduction of amino groups. Amino groups are important in organic synthesis and can participate in various reactions.
Intramolecular pyridine rings also affect their properties. The pyridine ring is aromatic, stable and can participate in the electrophilic substitution reaction. Although the reaction activity is lower than that of the benzene ring due to the electronegativity of the nitrogen atom, under appropriate conditions, electrophilic substitution can still occur at specific positions of the pyridine ring, such as bromide, nitrification, etc., which provides the possibility for its structural modification. According to the reaction conditions and reagents, different positions on the pyridine ring can be replaced to prepare derivatives with complex structures.
methyl is a power supply group, which is connected to the pyridine ring, which has an impact on the distribution of molecular electron clouds and changes the reactivity and selectivity of the pyridine ring. In the electrophilic substitution reaction, it may affect the entry position of the substituent and make the reaction more regioselectivity. In conclusion, 3 - bromo - 6 - methylpyridine - 2 - carbonitrile is rich in properties and has wide application prospects in the field of organic synthesis.

I don't know what the price range of 3-bromo-6-methylpyridine-2-carbonitrile is on the market. This compound is not a well-known commodity, and its price often varies depending on many factors.
First, purity has a great impact. For high purity, it is difficult to prepare, and the required technology and process are complicated, so the price is high; for low purity, it is relatively easy to prepare, and the price may be low.
Second, the purchase volume is also the key. Bulk purchases, due to economies of scale, the unit price may be reduced; for small purchases, sellers may price higher due to cost considerations.
Third, the relationship between supply and demand determines the price. If the market demand for this product is strong, but the supply is small, the price will rise; conversely, the demand is low and the supply is sufficient, and the price may decline.
Fourth, the source is different, and the price is different. Purchased from a known supplier, the quality may be guaranteed, but the price may be high; purchased from a small supplier or informal channels, the price may be low, but the quality is unpredictable.
To know the exact price range, you can check the quotations of different suppliers on the chemical product trading platform, such as Mobell, etc.; or communicate directly with the chemical raw material distributor to inquire about the price of this compound to obtain accurate price information.