3-Bromo-6-Iodoimidazo[1,2-a]Pyridine

3-Bromo-6-iodoimidazolo [1,2-a] pyridine has a wide range of uses and is often a key intermediate in the creation of new drugs in the field of medicinal chemistry. The unique structure of the combination of Gainpyridine and imidazole endows it with diverse biological activities and good pharmacological properties. Taking the development of anti-cancer drugs as an example, researchers have modified the structure of this compound to explore new molecular entities that have inhibitory effects on cancer cell proliferation. Bromine and iodine atoms in its structure can be used as reaction check points. Through various chemical reactions, different functional groups are introduced to change the interaction between drugs and targets, enhancing the targeting and lethality of cancer cells.
In the field of materials science, 3-bromo-6-iodoimidazolo [1,2-a] pyridine also has important uses. Because of its special electronic structure and conjugated system, it can be applied to the preparation of organic optoelectronic materials. For example, in the field of organic Light Emitting Diodes (OLEDs), rational molecular design and modification can optimize the luminous properties and charge transport capacity of materials, and improve the luminous efficiency, stability and color purity of OLED devices. In organic photovoltaic materials, its structural properties help to improve the efficiency of solar absorption and charge separation, providing new material options for the development of high-efficiency solar cells.
Furthermore, in the field of pesticide chemistry, this compound may be used as a lead compound for the development of new pesticides. In view of its unique structure and potential biological activity, or its inhibitory or killing effect on specific pests and pathogens, and through structural optimization, it is expected to improve its selectivity and environmental friendliness, reduce the impact on non-target organisms, and meet the needs of modern green pesticide development.

The synthesis of 3-bromo-6-iodoimidazolo [1,2-a] pyridine involves a variety of approaches. One is to introduce bromine and iodine atoms through a halogenation reaction using imidazolo [1,2-a] pyridine as the starting material. First, under suitable reaction conditions, such as in an organic solvent, under heat or light, imidazolo [1,2-a] pyridine is brominated to obtain a bromine-containing intermediate. After that, the bromine-containing intermediate is further iodinated with an iodine-substituted reagent, such as potassium iodide (KI) and an appropriate oxidant, such as hydrogen peroxide (H2O) or potassium persulfate (K2O), under suitable solvent and reaction conditions, to obtain 3-bromo-6-iodimidazolo [1,2-a] pyridine.
Another method is to use the pyridine derivative as the starting material to construct an imidazole ring through a multi-step reaction and introduce a halogen atom. First, the pyridine derivative is functionalized to make it have the activity check point related to the construction of the imidazole ring. Through a series of steps such as suitable nucleophilic substitution and cyclization reaction, the structure of imidazolo [1,2-a] pyridine is constructed, and then bromine and iodine atoms are introduced in sequence through bromination and iodization to achieve the synthesis of the target product.
Another way can start from simple organic raw materials and gradually build the molecular skeleton through multi-step reactions. For example, using nitrogen-containing and carbon-containing small molecules, through condensation, cyclization and other reactions, the basic structure of imidazolo [1,2-a] pyridine is first constructed, and then the bromine and iodine atoms are precisely introduced to specific positions by halogenation to achieve the synthesis of 3-bromo-6-iodazolo [1,2-a] pyridine. These methods have their own advantages and disadvantages, and it is necessary to consider the availability of raw materials, the difficulty of reaction conditions, the high and low yield and other factors according to the actual situation, and choose the appropriate one to use.

3-Bromo-6-iodoimidazolo [1,2-a] pyridine, is one of the organic compounds. In terms of physical properties, it is mostly solid at room temperature, but this is indeterminate, or varies due to the presence of impurities and differences in crystal morphology. Looking at its appearance, it is often white to light yellow powder or crystalline material. This color and morphology are due to the arrangement of atoms and the distribution of electron clouds in the molecular structure.
On solubility, this substance may be soluble in common organic solvents such as dichloromethane and chloroform. Due to the interaction between the molecular structure of these organic solvents and the molecular forces of 3-bromo-6-iodoimidazolo [1,2-a] pyridine, they can interact to disperse them. In water, its solubility is poor, because its molecular polarity is quite different from that of water molecules, it is difficult to form an effective solvation effect.
As for chemical properties, the presence of bromine and iodine atoms in the molecule gives it the characteristics of halogenated hydrocarbons. Bromine and iodine atoms can undergo nucleophilic substitution reactions. This is because the halogen atoms are electron-absorbing, so that the carbon atoms connected to them are partially positively charged and vulnerable to nucleophilic reagents. For example, when reacted with sodium alcohol, the halogen atoms can be replaced by alkoxy groups. And because of its imidazole-pyridine parent nuclear structure, it has certain aromatic and basic properties, and can participate in some acid-base related reactions, such as interacting with strong acids, the parent nitrogen atom can accept protons to form salt compounds. In addition, the compound may also participate in transition metal catalysis reactions, and halogen atoms can undergo coupling reactions under the action of metal catalysts to construct more complex organic molecular structures.

The price range of 3-bromo-6-iodoimidazolo [1,2-a] pyridine in the market is difficult to determine. This is due to the ever-changing market conditions, and its price often changes for various reasons.
First, the difference in production sources can cause price changes. If it is produced in large factories and the quantity of production is large, the price may be slightly cheaper; if it is refined in small workshops, the quantity is thin and the art is fine, and the price may be high.
Second, the quality is high or low, which is related to the price. Those who are pure and less miscellaneous are good for all kinds of karma, and the price will be high; if the quality is not good, and there are many and pure deficiencies, although there are other things, the price will not be high.
Third, the trend of demand and supply is also the pivot of price. There are many people who want it in the market, but the supply is small, the price will rise; if the supply exceeds the demand, the goods will accumulate and it will be difficult to sell, and the price may be reduced to promotion.
Fourth, the quantity purchased can also be shifted. Bulk buyers, merchants may give a good price for long-term friendship; small retail purchases, the price may be as usual, and it is difficult to make a discount.
In the past, the price of this product in the market ranged from a gram or tens of gold to hundreds of gold. However, this is only an image of the past. Today's market conditions are not comparable to those of the past, or due to the emergence of new technologies and changes in sources, the price is different from the past. To know the exact price, you should consult the chemical industry and traders, and get the exact price with real-time information.

3-Bromo-6-iodoimidazolo [1,2-a] pyridine is an organic compound, and its storage conditions are crucial to the stability and quality of the substance. According to the concept of "Tiangong Kaiwu", all kinds of substances have their suitable storage places, and this compound is no exception.
First of all, because of its certain chemical activity, it should be stored in a cool and dry place. If placed in a warm and humid place, it is easy to cause chemical reactions and cause it to deteriorate. Cover the humid gas, which is easy to make the compound absorb moisture, or catalyze some reactions such as hydrolysis; warm environment, it will speed up the molecular movement, causing it to react with surrounding substances. Therefore, choosing a cool and dry place, such as a well-ventilated warehouse, can reduce its contact with water vapor and high temperature, and maintain its chemical stability.
Secondly, this compound should be kept away from fire sources and strong oxidants. Its structural characteristics determine that it may have certain flammability or be prone to violent reactions with strong oxidants. If it is close to the fire source, in case of open flame or hot topic, there is a risk of combustion or even explosion; strong oxidants may also oxidize with the compound, changing its chemical structure and damaging its quality, so it needs to be stored at a safe distance from the fire source and strong oxidant.
In addition, the choice of storage containers is also critical. It is advisable to use containers with good sealing performance, such as glass bottles or specific plastic bottles. Glass bottles are chemically stable, not easy to react with compounds, and can effectively block water vapor and air; specific plastic bottles need to ensure that they do not swell or penetrate with compounds. The purpose of sealing is to prevent air from entering. Due to the oxygen, carbon dioxide and other components in the air or the reaction with compounds, the compound can also be avoided from volatilization and loss, and its purity and content can be maintained.
In short, the storage of 3-bromo-6-iodoimidazolo [1,2-a] pyridine should pay attention to the cool and dry environment, keep away from fire sources and strong oxidants, and use a suitable sealed container, so as to maintain its quality and chemical stability for a long time.