3-Bromo-6-chloro-2-methyl-5-nitropyridine

3-Hydroxy-6-chloro-2-methyl-5-nitropyridine, this is an organic compound. Looking at its structure and properties, it can be seen that it has a wide range of uses.
In the field of medicine, it may be a key pharmaceutical intermediate. Geinpyridine compounds often have diverse biological activities and can be chemically modified to introduce specific functional groups to meet the design needs of different drug molecules. By ingenious modification of the structure of 3-hydroxyl-6-chloro-2-methyl-5-nitropyridine, drugs with antibacterial, anti-inflammatory and anti-tumor effects can be created. For example, the synthesis of some antimicrobial drugs requires this as the starting material and goes through a multi-step reaction to build a complete drug molecular structure to achieve effective inhibition and killing of pathogens.
In the field of pesticides, it also plays an important role. Pyridine derivatives are often used to develop insecticides, fungicides and herbicides. The chemical structure of 3-hydroxyl-6-chloro-2-methyl-5-nitropyridine may endow pesticides with specific biological activities and mechanisms of action. For example, insecticides and herbicides that target specific pests or weeds can be designed, and their interaction with specific receptors or enzymes in the target organism can interfere with the growth and development of pests, inhibit the photosynthesis of weeds and other physiological processes, and achieve high-efficiency, low-toxicity and environmentally friendly pesticide effects. This compound can be used as a raw material for the synthesis of special functional materials. The functional groups it contains can participate in polymerization reactions, etc., to construct polymer materials with unique electrical, optical or mechanical properties. For example, through specific polymerization reactions, or to prepare optical materials that are sensitive to specific wavelengths of light, it can be used in optoelectronic devices, sensors and other fields, and its structural properties can achieve precise response and conversion to optical signals.

To prepare 3-bromo-6-chloro-2-methyl-5-nitropyridine, the following ancient methods can be used.
First, pyridine is used as the starting material. Before the introduction of methyl groups on the pyridine ring, 2-methylpyridine can be obtained by Fu-gram alkylation of pyridine with halomethane (such as chloromethane) in the presence of a suitable catalyst such as anhydrous aluminum trichloride. Then, 2-methylpyridine is nitrified. The mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as the nitrifying reagent. Under suitable temperature conditions, the nitro group will mainly enter the para-position of the methyl group to generate 2-methyl-5-nitropyridine. Next, the halogenation reaction is carried out, and the bromine atom is introduced first, and the liquid bromine is selected. Under the catalysis of appropriate Lewis acid (such as iron tribromide), the bromine atom will selectively enter the appropriate position on the pyridine ring to obtain 3-bromo-2-methyl-5-nitropyridine. Finally, chlorine atoms are introduced, and chlorine gas is used as the chlorine source. Under the action of light or a specific catalyst, the 6-chlorine substitution is completed to obtain the target product 3-bromo-6-chloro-2-methyl-5-nitropyridine.
Second, another approach can also be found. First, the pyridine is halogenated, such as using chlorine gas under light conditions to introduce chlorine atoms into the pyridine ring to obtain 6-chloropyridine. Then a nitration reaction is carried out. Under the action of mixed acid, the nitro group enters the specific position of the pyridine ring to generate 6-chloro-5-nitropyridine. Then the methylation reaction is carried out, and the introduction of 2-methyl is achieved in the presence of halomethane and an appropriate base to obtain 2-methyl-6-chloro-5-nitropyridine. Finally, 3-bromo-6-chloro-2-methyl-5-nitropyridine can be successfully synthesized by bromination reaction with liquid bromine and corresponding catalysts.
During the synthesis process, it is necessary to pay attention to the precise control of the reaction conditions at each step, including temperature, reagent dosage and reaction time, so as to improve the yield and purity of the target product.

3-Bromo-6-chloro-2-methyl-5-nitropyridine, this is an organic compound. Its physical properties are quite critical, and it is widely used in chemical, pharmaceutical and other fields. It is related to the reaction process and product characteristics, so it cannot be underestimated.
Looking at its appearance, under normal temperature and pressure, it is mostly in the state of a crystalline solid, with a fine texture, and the color may range from white to light yellow. This color and morphology are not only its external characteristics, but also closely related to its internal structure and intermolecular forces.
When talking about the melting point, it is about [X] ° C. The characteristic of melting point is extremely important for the purification and identification of compounds. By accurately measuring the melting point, its purity can be judged. If the melting point of the sample is consistent with the theoretical value and the melting range is extremely narrow, it usually indicates that the purity is quite high; conversely, if the melting point deviation is large and the melting range is wide, the purity is worrying.
The boiling point is also a key physical property, about [X] ° C. The boiling point reflects the energy required for the compound to transform from liquid to gaseous state, and is closely related to the intermolecular force. The level of the boiling point affects the phase change of the compound at different temperatures, and is an indispensable parameter in chemical operations such as distillation and separation.
In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and acetone. In water, the solubility is relatively low. This difference in solubility is due to the interaction between the polarity of the compound molecule and the polarity of the solvent molecule. The polarity of organic solvents is similar to the molecular polarity of the compound, and according to the principle of "similar miscibility", the solubility is better; although the polarity of water is strong, it is very different from the molecular structure of the compound, resulting in poor solubility. This solubility characteristic is of great significance in the extraction, separation and choice of reaction solvents of compounds.
The density is about [X] g/cm ³, and the density reflects the mass per unit volume of the substance. It is an important reference index in the process of solution preparation and reaction material measurement. Only by accurately knowing the density can the proportion of the reaction material be accurately controlled to ensure the smooth progress of the reaction. These physical properties of 3-bromo-6-chloro-2-methyl-5-nitropyridine are related to each other and together build their unique physical and chemical characteristics, which lay the foundation for their application in various fields.

3-Hydroxy-6-chloro-2-methyl-5-nitropyridine is an organic compound. This compound has the following chemical properties:
1. ** Basic **: The pyridine ring contains nitrogen atoms, nitrogen has lone pairs of electrons, and can bind protons, showing a certain alkalinity. In acidic solutions, it can be combined with protons to form pyridine salts.
2. ** Nucleophilic Substitution Reaction **: Due to the presence of chlorine atoms on the ring, this is a good leaving group. Under suitable nucleophilic reagents and reaction conditions, chlorine atoms are easily replaced by nucleophilic reagents. For example, when reacting with sodium alcohol, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds; when reacting with amines, nitrogen-containing substituted derivatives can be formed.
3. ** Redox Reaction **:
- ** Oxidation **: The methyl group in its molecule can be oxidized under the action of an appropriate oxidant. For example, under the action of strong oxidants such as potassium permanganate, methyl groups may be oxidized to carboxyl groups to obtain carboxyl-containing pyridine derivatives.
- ** Reduction **: Nitro groups are oxidizing groups and can be reduced. In the reduction system composed of iron powder, zinc powder and other metals with hydrochloric acid, or under the condition of catalytic hydrogenation, the nitro group can be gradually reduced, first to nitroso group, and then reduced to amino group to obtain 3-hydroxy- 6-chloro-2-methyl-5-aminopyridine.
4. ** Electrophilic Substitution Reaction **: Although the electron cloud density of the pyridine ring is lower than that of the benzene ring, the electrophilic substitution reaction can still occur under certain conditions. Since chlorine, nitro, etc. are electron-withdrawing groups, the electron cloud density of the pyridine ring will be reduced, and the electrophilic substitution reaction activity is lower than that of the benzene ring, and the substitution position is mainly affected by the localization effect of these groups, which usually occurs at the position where the electron cloud
5. ** Hydroxy-related reactions **: The hydroxyl groups in the molecule have the general properties of alcohol hydroxyl groups. It can be esterified with acids, and reacted with carboxylic acids to form corresponding esters under the action of catalysts such as concentrated sulfuric acid; it can also be dehydrated under the action of dehydrating agents to form olefins or ether compounds.

Wen Jun's inquiry is about the price range of 3-bromo-6-chloro-2-methyl-5-nitropyridine in the market. This compound, in the field of chemical industry, has a wide range of uses, and its price varies due to many factors.
First, the cost of production, the price of raw materials, the difficulty of preparation, and the amount of energy consumption all affect. If raw materials are rare and difficult to find, or the preparation process is cumbersome, the cost is high, and the price also rises.
Second, the supply and demand of the market. If there are many people in demand, the demand will exceed the supply, and the price will rise; on the contrary, if the supply exceeds the demand, the price will fall.
Third, the difference in quality. For high purity, due to the difficulty of refining, the price must be higher than for low purity.
As far as I know, the current market price may range from tens to hundreds of yuan per gram. However, this is only an approximate number, and the actual price may vary depending on the size of the purchase quantity, the region of the transaction, and the time period of the transaction. If the purchase quantity is quite large, the merchant may give a discount; in different places, due to differences in transportation, taxes, etc., the price is also different; and the market conditions change from time to time, and the price at that time may not be applicable to the present. Therefore, if you want to know the exact price, you need to consult various chemical raw material suppliers and carefully examine their quotations to obtain an accurate number.