3-Bromo-5-methoxypyridine

3 - Bromo - 5 - methoxypyridine is an organic compound, its physical properties are quite critical, and it is widely used in chemical synthesis and other fields.
Looking at its properties, under normal temperature and pressure, this substance is mostly in a solid state, but its specific appearance may vary slightly due to factors such as purity and crystalline morphology. It is usually white to light yellow crystalline powder, just like fine dust aggregation and forming, and may have a unique luster under light.
When it comes to melting point, it has been determined by many experiments to be in the range of 58 - 62 ° C. In this temperature range, the substance gradually melts from solid to liquid state, which is of great significance for its purification and processing operations under specific conditions. When the temperature reaches the lower limit of this range, the intermolecular force gradually weakens, the lattice structure begins to disintegrate, and the substance starts the melting process.
The boiling point is also an important physical property. At standard atmospheric pressure, its boiling point is about 245-247 ° C. When the temperature rises to the boiling point, the molecule obtains enough energy to break free from the liquid phase and escape into the gas phase. The boiling point value determines its condition setting in separation operations such as distillation.
In terms of solubility, 3-Bromo-5-methoxypyridine is soluble in a variety of organic solvents, such as common ethanol, dichloromethane, and ether. In ethanol, just like salt dissolves in water, it can interact with ethanol molecules through intermolecular forces, uniformly disperse, and form a uniform and stable solution. In water, its solubility is very small. Due to the poor hydrophilicity of the pyridine ring and bromine, methoxy and other groups in the molecular structure, the force between the water molecule and the compound is difficult to defeat the intermolecular force of the compound itself, so it is difficult to dissolve.
In addition, the density of the substance is about 1.54 g/cm ³, which indicates that its unit volume mass is relatively large. In the process of participating in chemical reactions or preparation, this density data is indispensable when it involves volume and mass conversion. And because it contains atoms such as bromine and nitrogen, it will show specific absorption peaks and signals in infrared spectroscopy, nuclear magnetic resonance and other spectroscopic characterizations, providing a strong basis for its structure identification and purity analysis.

3-Bromo-5-methoxypyridine is one of the organic compounds. Its chemical properties are unique and of great research value.
As far as nucleophilic substitution reactions are concerned, bromine atoms are quite active. Due to the electronic effect of the pyridine ring, bromine atoms are more likely to leave, and can react with many nucleophilic reagents, such as alkoxides and amines. Taking alkoxides as an example, under suitable conditions, alkoxy anions will attack the carbon atoms connected to bromine, and bromine ions will leave, thereby generating corresponding ether compounds. This reaction is of great significance in organic synthesis and can lay the foundation for the construction of complex organic molecular structures. < Br >
In electrophilic substitution reactions, methoxy is a donor electron group, which increases the electron cloud density of the pyridine ring, especially in the ortho and para-methoxy sites. However, the electron-absorbing properties of the nitrogen atom of the pyridine ring will hinder the electrophilic substitution reaction to a certain extent. In general, the electrophilic substitution reaction mainly occurs in the methoxy para-site, because the electron cloud density at this position is relatively high and the steric resistance is small. For example, under specific catalyst and reaction conditions, halogenation can occur with halogenated reagents to generate derivatives that introduce halogen atoms at different positions.
3-Bromo-5-methoxy pyridine can also participate in metal-catalyzed coupling reactions. Under the action of metal catalysts such as palladium and nickel, its bromine atom can couple with reagents containing carbon-metal bonds, such as organoboron reagents and organozinc reagents. This reaction can efficiently form carbon-carbon bonds, and is widely used in drug synthesis, materials science and other fields. It can be used to synthesize organic compounds with specific structures and functions.
In addition, the nitrogen atom of the pyridine ring has lone pair electrons and has a certain alkalinity, which can react with acids to form corresponding salts. This property can be exploited under certain separation, purification operations and specific reaction conditions, which can affect the chemical behavior of the compound. In conclusion, 3-bromo-5-methoxypyridine has rich and diverse chemical properties, and has important applications in many fields such as organic synthesis. Through in-depth exploration and rational application of its chemical properties, it can achieve efficient synthesis and functionalization of many organic compounds.

The common synthesis methods of 3-bromo-5-methoxypyridine are very important in the field of organic synthesis. There are many ways to synthesize it, and this is a detailed description for you.
First, the synthesis method using pyridine as the starting material. The pyridine is methoxylated first, and a combination of dimethyl sulfate and a base can be used to introduce a methoxy group at a specific position on the pyridine ring at a suitable temperature and reaction conditions. Then, the bromination reaction is carried out. The bromination reagent can be selected from liquid bromine, N-bromosuccinimide (NBS), etc. Taking NBS as an example, in the presence of an initiator such as benzoyl peroxide, heating or illumination can cause bromine atoms to selectively replace hydrogen atoms at the desired positions on the pyridine ring to obtain 3-bromo-5-methoxypyridine.
Second, the method of conversion via halogenated pyridine derivatives. If there is a suitable halogenated pyridine, such as 5-halogenated pyridine, the methoxy group can be introduced by a nucleophilic substitution reaction. The nucleophilic reagent can be sodium methoxide, etc. In a suitable solvent, such as dimethylformamide (DMF), the reaction can be heated to achieve the substitution of methoxy to halogen atoms. After that, according to the suitable conditions of the bromination reaction, bromine atoms are introduced to achieve the synthesis of the target product.
Third, with the help of heterocyclic construction strategy. Through suitable organic small molecules, such as compounds containing nitrogen and oxygen heteroatoms, pyridine rings are constructed through multi-step reactions, and methoxy and bromine atoms are introduced at the same time. For example, in a series of condensation and cyclization reactions with β-ketone esters, ammonia sources and bromine reagents, the structure of pyridine rings is gradually constructed, and the position of substituents is precisely controlled to obtain 3-bromo-5-methoxy pyridine.
These several synthesis methods have their own advantages and disadvantages, and it is necessary to weigh and select the appropriate method according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the target product, in order to achieve the purpose of efficient synthesis of 3-bromo-5-methoxypyridine.

3-Bromo-5-methoxypyridine is useful in various fields such as medicinal chemistry and materials science.
In the field of medicinal chemistry, it is often a key intermediate for the production of various drugs. Due to the properties of bromine and methoxy groups in the structure, the lid can cause the reaction to occur in a directional manner, which helps to construct complex drug molecular structures. For example, through nucleophilic substitution reactions, bromine atoms can be replaced by various nucleophiles, thereby introducing different functional groups to combine compounds with specific biological activities. This compound may act on specific biological targets and have potential value in the treatment of certain diseases. For example, when developing antagonists or agonists for specific receptors, 3-bromo-5-methoxy pyridine can be used as a starting material to obtain target drug molecules through multi-step reactions.
In the field of materials science, it also has applications. It can be chemically modified and introduced into the structure of polymer materials. Due to the electron supply of methoxy groups and the reactivity of bromine atoms, it may improve the electrical and optical properties of materials. For example, if it is used as a monomer to participate in the polymerization reaction, the resulting polymer may have unique electrical conductivity or fluorescence properties, and may play an important role in the preparation of organic Light Emitting Diode (OLED) materials and conductive polymer materials, helping to improve the properties and functional diversity of materials.
In the field of organic synthetic chemistry, it is an important synthetic building block. Chemists can take advantage of its structural characteristics to carry out various organic reactions, such as metal-catalyzed coupling reactions. Through such reactions, it can be connected with other organic fragments to construct more complex and diverse organic molecular structures, providing important basic raw materials and reaction substrates for the development of organic synthetic chemistry, and promoting the creation of new compounds and the progress of organic synthesis methodologies.

3 - Bromo - 5 - methoxypyridine is a key intermediate in organic synthesis and is widely used in many fields such as medicine and pesticides. Its market price changes are often influenced by many factors.
First of all, raw materials. The preparation of this compound, the cost of raw materials is significant. If the raw materials such as pyridine, bromide, and methoxypyridine required for its preparation fluctuate due to market supply and demand, production process changes or geopolitics, the price of 3 - Bromo - 5 - methoxypyridine will also fluctuate. If the scarcity and price of pyridine raw materials increases, the cost of the product will increase and the market price will also increase.
Let's talk about the production process. Advanced and efficient production processes can reduce production costs. Optimization of new catalysts or reaction conditions can improve reaction yield and selectivity, reduce waste generation and energy consumption. Manufacturers with advanced processes have low product costs and are priced more competitively in the market. If the new process is popularized, the overall market price may decline; conversely, process bottlenecks cause low production efficiency and prices may remain high.
The relationship between market supply and demand is also key. In pharmaceutical research and development, if the research and development of new drugs with 3-Bromo-5-methoxypyridine as an intermediate is progressing smoothly, clinical demand will increase sharply, and the supply will exceed the demand, and the price will rise. However, if the market competition is fierce and many manufacturers expand production, resulting in oversupply, prices may be under pressure.
Regional differences cannot be ignored. Different regions have different prices due to different economic development levels, policies and regulations, and logistics costs. In developed areas, due to high labor and environmental protection costs, product prices may be higher than in developing areas. And logistics costs affect the transportation distance and method. In remote areas, due to inconvenient transportation, costs increase, and selling prices will also increase.
To sum up, the market price of 3-Bromo-5-methoxypyridine is difficult to be fixed, and it varies from time to time due to factors such as raw materials, processes, supply and demand, and regions. To know its exact price, it is necessary to pay attention to market dynamics in real time and observe the changes of various influencing factors in detail.