3-Bromo-5-iodo-2-aminopyridine

3-Bromo-5-iodine-2-aminopyridine is one of the organic compounds. It has a halogen atom and an amino group, so it has unique chemical properties.
In this compound, the activities of bromine and iodine halogen atoms are quite different. Bromine atoms are smaller than iodine atoms and have slightly higher electronegativity. In nucleophilic substitution reactions, the carbon-halogen bond where the bromine atom is located is shorter and stronger than the bond where the iodine atom is located. However, iodine atoms may participate preferentially in specific reactions due to their large atomic radius and good polarization, resulting in different reaction paths.
Amino groups are electron-rich groups, which can provide electrons and increase the electron cloud density of the pyridine ring, especially the ortho and para-sites. This electronic effect causes the activity of the electrophilic substitution reaction on the ring to change, and the reaction check point is also affected by the orientation.
In the nucleophilic substitution reaction, the halogen atom can be the target of the nucleophilic reagent. If the nucleophilic reagent has strong nucleophilicity, bromine and iodine atoms may be replaced in sequence, and the product depends on the reaction conditions and the type of nucleophilic reagent.
In addition, amino groups can participate in a variety of reactions, such as salting with acids, or participating in condensation reactions under suitable conditions, interacting with carbonyl compounds such as aldodes and ketones to generate derivatives such as imines. < Br >
Because of its aromatic and stable structure, the pyridine ring often maintains the integrity of the ring when participating in the reaction, and the reactivity of the halogen atom and the amino group endows this compound with various reaction possibilities. It may have important uses in the field of organic synthesis and can be used as an intermediate. After a series of transformations, complex organic molecules with specific functions can be prepared.

3-Bromo-5-iodine-2-aminopyridine is also an important compound in organic synthesis. Its common synthesis method is that dolaidine derivatives are used as starting materials and are obtained through several steps of conversion.
One method starts with 2-aminopyridine and conducts halogenation first. The capsid group is an ortho-para-site group, which can guide halogen atoms to specific positions. Under suitable reaction conditions, 3-bromo-2-aminopyridine can be obtained by interacting with brominating reagents (such as liquid bromine, N-bromosuccinimide, etc.). In this step, attention should be paid to the choice of reaction temperature, solvent and catalyst to control the position and degree of bromination.
Then, 3-bromo-2-aminopyridine is iodized. Commonly used iodizing reagents such as potassium iodide are combined with oxidants (such as hydrogen peroxide, periodic acid, etc.). The function of the oxidant is to oxidize iodine ions into active iodine species, and then undergo electrophilic substitution with the pyridine ring, introducing iodine atoms at the 5-position, and finally obtaining 3-bromo-5-iodine-2-aminopyridine. This step also requires fine regulation of the reaction conditions to achieve higher yield and selectivity.
Another way may be to protect or modify other positions of the pyridine ring first, and then introduce bromine, iodine atoms and amino groups in sequence. However, these methods and steps may be more complicated and need to be weighed according to the actual situation. When synthesizing this compound, the optimization of the reaction conditions at each step is extremely critical, which is related to the purity and yield of the product. And during the reaction process, the use of reagents and the discharge of waste need to be properly handled to conform to the concept of green chemistry.

3-Bromo-5-iodine-2-aminopyridine has important applications in the fields of medicine, materials science, and organic synthesis.
In the field of medicine, it is a key intermediate for the synthesis of many bioactive compounds. Due to its unique structure, it can be chemically modified to construct molecules with high affinity for biological targets. For example, in the development of anti-cancer drugs, it can be used to design novel small molecule inhibitors that target specific carcinogenic proteins and interfere with cancer cell proliferation and survival signaling pathways to achieve the purpose of treating cancer.
In the field of materials science, this compound can be used to prepare materials with special photoelectric properties. It contains halogen atoms and amino groups, which can participate in specific chemical reactions, regulate the molecular structure and electron cloud distribution of materials, and then affect the conductivity and fluorescence of materials. For example, it can be introduced into polymer systems to prepare organic Light Emitting Diode (OLED) materials with unique luminescent properties for display technology to improve display effect.
In the field of organic synthesis, 3-bromo-5-iodine-2-aminopyridine can selectively undergo substitution and coupling reactions according to different reaction conditions due to the difference in the activity of bromine, iodine and amino groups in the molecule. Such as the coupling reaction catalyzed by palladium, complex pyridine derivatives can be easily constructed, providing an effective way for the synthesis of various natural products, drug lead compounds and functional materials. Its multi-activity check point characteristics greatly expand the strategies and methods of organic synthesis, and help chemists create organic molecules with diverse structures and unique functions.

It is not easy to determine the market price of 3-Bromo-5-iodo-2-aminopyridine. This compound may have applications in chemical industry, pharmaceutical research and development, and other fields. Its price is determined by the cost of raw materials, the difficulty of preparation, and market supply and demand.
If the raw materials are easy to obtain, the preparation method is simple and mature, and the supply exceeds the demand, the price may be cheap; on the contrary, if the raw materials are rare, difficult to prepare, and there are many applicants, the price will be high. Today, I have not obtained the exact price, but it can be used. Under normal market conditions, if it is a small supply of laboratory grade and of high quality, the price per gram may be between tens and hundreds of gold. If it is an industrial-scale block trade, considering the economies of scale, the unit price may be reduced, but it also depends on the specific quantity and quality.
And the market conditions are changing rapidly, and the development of new sources, technological innovation, and policy improvement can all cause their prices to fluctuate. To know its accurate market price, you must consult chemical raw material suppliers, professional chemical trading platforms, or negotiate with industry experts to get a near-real price.

3-Bromo-5-iodine-2-aminopyridine is a kind of organic compound. Its storage conditions are of paramount importance and are related to the quality and stability of this compound.
This compound should be stored in a cool place, because the temperature is too high, it is easy to cause chemical reactions and damage its structure and properties. Do not store it in a hot place to prevent its deterioration. It should also be placed in a dry place. Moisture is easy to cause hydrolysis or other adverse reactions. Therefore, the warehouse must be kept dry and not invaded by moisture.
Furthermore, it needs to be protected from light and shade. Light can often trigger photochemical reactions, causing the chemical bonds of the compound to break or rearrange, causing it to lose its original chemical properties. Therefore, it is advisable to use a brown bottle or an opaque container and place it in a dark place without direct sunlight.
In addition, this compound may be toxic and dangerous. When storing, it should be isolated from oxidants, acids, bases and other substances. Due to its chemical activity, if it is improperly contacted with other substances, or causes a violent reaction, it is at risk of ignition and explosion.
When stored, it should also be properly marked, indicating its name, nature, hazards and storage conditions, so that contacts can be seen at a glance to prevent misuse or improper disposal, and to ensure the safety of storage and use.