3-Bromo-5-fluoropyridine-2-carboxylic acid

3-Bromo-5-fluoropyridine-2-carboxylic acid, which has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of new drugs. Geinpyridine ring structure is crucial in many drug molecules, and the introduction of bromine and fluorine atoms can significantly change the physical, chemical and biological activities of compounds. By means of organic synthesis, using 3-bromo-5-fluoropyridine-2-carboxylic acid as the starting material, complex molecular structures with specific pharmacological activities can be constructed, or used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs.
In the field of pesticides, it also has its uses. It can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. Pyridine compounds often have unique biological activities against insects, plant pathogens, etc. After appropriate chemical modification, pesticides synthesized on the basis of 3-bromo-5-fluoropyridine-2-carboxylic acid may have good insecticidal, bactericidal and herbicidal effects, and are relatively friendly to the environment, in line with the current trend of green pesticide development.
In addition, in the field of materials science, they may also participate in the synthesis of some functional materials. Organic compounds containing fluorine and bromine may exhibit special properties in optoelectronic materials, such as adjustable material electron transport properties, optical properties, etc., providing the possibility for the development of new organic optoelectronic materials. In conclusion, 3-bromo-5-fluoropyridine-2-carboxylic acids have important application value in many fields and are a kind of key compounds in organic synthesis.

There are many different paths for the synthesis of 3-bromo-5-fluoropyridine-2-carboxylic acid. One of the common ones is to use pyridine as the starting material. First, the carboxyl group is introduced into the pyridine ring, which can be catalyzed by pyridine and carbon dioxide under specific conditions with a suitable catalyst, such as under high temperature and pressure and under the action of a specific metal catalyst, to induce the carboxylation reaction of pyridine and carbon dioxide to obtain pyridine-2-carboxylic acid derivatives. Then, on the basis of this derivative, bromine and fluorine atoms are introduced at specific positions. When introducing bromine atoms, suitable brominating reagents, such as N-bromosuccinimide (NBS), can be selected. In the presence of appropriate solvents and initiators, the substitution of bromine atoms at specific positions in the pyridine ring can be achieved. Usually, the substitution check point can be controlled according to the electron cloud distribution of the pyridine ring and the reaction conditions. When introducing fluorine atoms, fluorine-containing reagents, such as potassium fluoride, can be used to react in a suitable organic solvent in the presence of a phase transfer catalyst to achieve the substitution of fluorine atoms at the target position, thereby preparing 3-bromo-5-fluoropyridine-2-carboxylic acid.
Second, other nitrogen-containing heterocyclic compounds can also be used as starting materials to construct pyridine rings through multi-step reactions, and carboxyl groups, bromine atoms and fluorine atoms are introduced at the same time. For example, a suitable nitrile compound and a fluorine-containing and bromine-containing reagent undergo cyclization reaction under basic conditions. First, a fluorine-containing and bromine-containing pyridine ring structure is constructed, and then the nitrile group is converted into a carboxyl group through hydrolysis and other reactions, and then the target product 3-bromo-5-fluoropyridine-2-carboxylic acid is obtained.
Or, halogenated pyridine derivatives can be used as starting materials, and the desired substituents can be gradually introduced through a series of operations such as selective halogen atom exchange reaction and carboxyl If a halogenated pyridine is used as a raw material, an organometallic intermediate is formed with a suitable metal reagent, and then a carboxyl group is introduced by reacting with carbon dioxide, and then a bromine atom and a fluorine atom are introduced through a halogen atom exchange reaction, which can also achieve the purpose of synthesizing 3-bromo-5-fluoropyridine-2-carboxylic acid. Different synthesis methods have their own advantages and disadvantages, and they need to be used according to actual needs and conditions.

3-Bromo-5-fluoropyridine-2-carboxylic acid is a kind of organic compound. It has unique physical properties and is widely used in the field of organic synthesis.
The appearance of this compound is often white to pale yellow crystalline powder, and it is delicate in appearance. Its melting point is usually within a specific range, but the exact value will vary depending on the purity of the sample and the measurement conditions, roughly around hundreds of tens of degrees Celsius. The determination of the melting point is crucial in identifying its purity and judging the properties of the substance.
In terms of solubility, 3-bromo-5-fluoropyridine-2-carboxylic acid exhibits different solubility in organic solvents. Common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF) have good solubility to it. In dichloromethane, molecules and solvent molecules can be uniformly dispersed through specific interactions to form a clear solution. In water, its solubility is relatively poor, because the hydrophobic part of the molecular structure accounts for a large proportion, and the force between water molecules is weak.
In addition, the density of this compound is also an important physical property. Although the exact density data needs to be determined by precise experiments, it is speculated based on its molecular structure and similar compound properties that its density may be different from or greater than that of water. The value of density is related to the measurement and separation of substances in chemical production and experimental operations.
The physical properties of 3-bromo-5-fluoropyridine-2-carboxylic acids are of great significance for their applications in organic synthesis, drug development and other fields. Its melting point, solubility and density provide key basis for synthesis process optimization, reaction conditions selection and product separation and purification.

What you are inquiring about is the market price of 3-bromo-5-fluoropyridine-2-carboxylic acid. However, the market price of this chemical often varies due to various factors such as time and place, supply and demand, quality, etc. It is difficult to generalize.
In the past, if you were in the market of chemical raw materials, the price might vary according to the quantity. When the quantity is small, it may be a high price to meet the needs of small cases; if you buy in large quantities, the price may be slightly reduced for profit.
Looking at the records of past chemical market, the price of this product may be affected by the production of raw materials and the simplicity of the process. If the raw materials are abundant and easy to obtain, the process is simple and efficient, and the price may be stable and flat; conversely, the raw materials are rare and difficult to find, and the process is miscellaneous and expensive, and the price will rise.
And due to market competition, the prices demanded by various merchants are also different. Reputable firms may have high prices because of their excellent quality and good after-sales service; emerging merchants may compete for customers at low prices for the expansion of the market.
In this world, the rules of international trade and the administration of taxes are all related to their prices. Changes in tariffs and transportation costs are all variables of price. Therefore, if you want to know the exact price, you should consult the chemical industry, observe the trading market, and consider the current situation to obtain a more accurate number.

For 3-bromo-5-fluoropyridine-2-carboxylic acid, many matters need to be paid attention to during storage and transportation.
Its properties may be more active, and it is easy to change when heated. Therefore, when storing, the first temperature should be controlled. It should be placed in a cool place, protected from direct sunlight, to avoid decomposition or deterioration due to excessive temperature. If it is midsummer and the sun is blazing, if there is no temperature control equipment in the warehouse, this product may be damaged.
Humidity should not be ignored. This compound may be hygroscopic, the humidity is too high, or it may cause deliquescence, which will affect the quality. When the place of storage is kept dry, a desiccant can be prepared in the warehouse. Check the change of humidity frequently. If the humidity exceeds the appropriate level, apply a dehumidification policy quickly.
During transportation, stability is essential. This item may be dangerous to a certain extent, and the packaging must be solid. Use a special container to hold it to prevent vibration and collision from causing damage to the package. And the transportation vehicle is selected to be stable, and the traffic should be avoided on the bumpy road.
And because of its special chemical properties, it cannot be mixed with other things. Such as strong oxidizing agents, strong alkalis, etc., contact with it, or react violently, causing danger.
In addition, the clarity of labels is also very important. On the package, the name, nature, hazard and emergency measures must be clearly written. In case of an accident, people can take the correct measures according to the label to reduce the risk. In this way, the storage and transportation of 3-bromo-5-fluoropyridine-2-carboxylic acid can ensure its quality and avoid danger.