3-Bromo-5-cyclopropylpyridine

3-Bromo-5-cyclopropylpyridine is an organic compound with unique chemical properties and is very important in the field of organic synthesis.
In this compound, the bromine atom has high activity and is prone to substitution reactions. As a good leaving group, the Guine bromide atom can be replaced by other groups under the action of nucleophiles. For example, when reacting with nucleophiles such as sodium oxide, the bromine atom will leave, and the anion of alcohol oxide attacks the corresponding check point to form ether derivatives. This reaction is widely used in organic synthesis steps such as building carbon-oxygen bonds.
The cyclopropyl structure also gives the compound special properties. Cyclopropyl has a high cyclic tension, which makes it exhibit unique activity in chemical reactions. It can participate in some reactions involving the release of cyclic tension, such as ring-opening reactions with electrophilic reagents. Electrophilic reagents attack cyclic propyl, causing the ring to open, resulting in the formation of products with different carbon frameworks, thus expanding the path of organic synthesis and providing the possibility for the construction of more complex molecular structures.
Furthermore, the presence of a conjugate system in the pyridine ring makes the whole molecule stable. At the same time, the presence of nitrogen atoms on the pyridine ring makes it weakly basic and can react with acids to form salts. In some organic reaction systems, this property can be used to adjust the reaction environment and affect the selectivity and rate of the reaction.
In addition, 3-bromo-5-cyclopropylpyridine can also be used as a key intermediate in the synthesis of many complex organic molecules. By rationally designing the reaction route, using the activity of bromine atom and cyclopropyl group, the carbon skeleton and functional group of the target molecule are gradually constructed, providing important synthetic building blocks for medicinal chemistry, materials science and other fields.

3-Bromo-5-cyclopropylpyridine is also an organic compound. It has a wide range of uses in the field of medicinal chemistry and is a key intermediate for the synthesis of many special drugs. It can be combined with other reagents through a specific chemical reaction path to construct a molecular structure with specific pharmacological activities, thus laying the foundation for the creation of drugs for the treatment of diseases such as inflammation and tumors.
In the field of materials science, it also shows unique functions. Or it can participate in the preparation of materials with special photoelectric properties, which can be used in cutting-edge fields such as organic Light Emitting Diodes (OLEDs) and solar cells. Due to its unique molecular structure, it may endow materials with excellent charge transport properties and stability, thus enhancing the efficiency and service life of related devices.
In the field of pesticide chemistry, it is also indispensable. Through rational molecular design and synthesis, it can be converted into highly efficient, low-toxic and environmentally friendly pesticide active ingredients, which have significant pest control effects, contribute to the sustainable development of agriculture, ensure the harvest of crops, and reduce the negative impact on the ecological environment.
In short, 3-bromo-5-cyclopropylpyridine plays a crucial role in many important fields such as medicine, materials and pesticides, and has made significant contributions to promoting technological innovation and development in various fields.

The synthesis method of 3-bromo-5-cyclopropylpyridine has been studied a lot in the past, and now it is a digital method for you.
First, 5-cyclopropylpyridine is used as the starting material to react with brominating reagents under suitable conditions. Liquid bromine is often used as the source of bromination, and in a suitable solvent such as dichloromethane, at low temperature and in the presence of catalysts such as iron powder or iron tribromide, liquid bromine and 5-cyclopropylpyridine undergo electrophilic substitution reaction. In this process, the liquid bromine is polarized under the action of the catalyst, and the positive bromine ion attacks the third position on the pyridine ring to form 3-bromo-5-cyclopropylpyridine. After the reaction, the pure product can be obtained by extraction, washing, drying, distillation and other operations.
Second, a suitable intermediate containing cyclopropyl and bromine atoms is prepared first, and then a pyridine ring is formed by cyclization. For example, a specific halogenated hydrocarbon is coupled with a cyclopropylboronic acid derivative through palladium catalysis to obtain a halogenated aromatic hydrocarbon containing cyclopropyl. Under the action of base and suitable catalyst, the halogenated aromatic hydrocarbon and nitrile compound can form a ring through multi-step reaction to form a pyridine ring, and then obtain 3-bromo-5-cyclopropylpyridine. Although this path is a little complicated, it can flexibly adjust the reaction check point and improve the purity of the product.
Third, 3-bromopyridine is used as the starting material to synthesize the target product by introducing cyclopropyl. 3-Bromo-pyridine is reacted with Grignard reagents such as cyclopropyl magnesium halide in anhydrous ether or tetrahydrofuran solvents. The cyclopropyl negative ions of Grignard reagents attack the pyridine ring to form 3-bromo-5-cyclopropyl pyridine. After the reaction, careful operation is required to prevent the decomposition of the product. Regular separation and purification methods can be used to obtain pure 3-bromo-5-cyclopropyl pyridine.
Synthesis methods have their own advantages and disadvantages, and need to be carefully selected according to actual needs, such as raw material availability, cost, product purity and other factors.

3-Bromo-5-cyclopropylpyridine is an important compound commonly used in organic synthesis. During storage and transportation, it is necessary to pay attention to many key matters to ensure its quality and safety.
First words storage. This compound should be placed in a cool, dry and well-ventilated place. Because it is quite sensitive to humidity, if the storage environment is humid, it is easy to cause adverse reactions such as hydrolysis, which will damage its purity and structural integrity. Therefore, the humidity of storage should be controlled at a low level, generally with a relative humidity of not more than 60%. And it needs to be kept away from heat sources and open flames. Because of its flammability, heat or exposure to open flames may cause fires and endanger safety. In addition, it should be stored separately from oxidizing agents, acids, alkalis and other substances. Due to its active chemical properties, contact with the above substances is prone to violent chemical reactions, or even explosions.
As for transportation, there are also many details. Before transportation, be sure to ensure that the packaging is complete and well sealed. Packaging materials need to be corrosion-resistant and pressure-resistant to prevent package damage and leakage during transportation. During transportation, collisions and vibrations should be strictly avoided. Violent vibrations or changes in its internal structure will affect quality. When transporting vehicles, a smooth route should be selected to avoid traffic and crowded places. At the same time, transportation personnel must be professionally trained, familiar with the characteristics of the compound and emergency treatment methods, and can respond quickly and correctly in case of emergencies.
In summary, 3-bromo-5-cyclopropylpyridine has strict requirements in terms of environment, packaging and personnel during storage and transportation. Only by strictly controlling all aspects can it be kept safe for subsequent use.

I don't know what the market value of 3-Bromo-5-cyclopropylpyridine is. This compound is not often available, and its market value depends on factors such as supplier, quantity, and quantity.
If you want to know its value, it is often necessary to provide it to different suppliers. At this site, the phase can be obtained according to different specifications. Some suppliers sell it in small quantities, and it can be reduced or slightly higher in the preliminary study of the room. If the quantity is large, if it is required for industrial use, it can be reduced due to the efficiency of the mold.
In addition, its synthesis is easy and also affects the quality. If the synthesis requires special anti-waste parts and high cost, the cost is high, and the market price is also high. And the supply and demand of the market are also high, if the demand is strong and the supply is low, the price will rise; conversely, the supply will be high or low in demand.
Therefore, in order to obtain the market value of this compound, it is advisable to self-check the suppliers before you can know its approximate price.