3-Bromo-4-pyridinecarboxaldehyde

3 - Bromo - 4 - pyridinecarboxaldehyde, Chinese name 3 - bromo - 4 - pyridyl formaldehyde, is a member of the family of organic compounds. It has many unique chemical properties and is widely used in the field of organic synthesis.
The chemical properties of this substance bear the brunt of the reactivity of the aldehyde group. The aldehyde group is an extremely active functional group and can participate in many classical organic reactions. For example, it can undergo nucleophilic addition reactions with nucleophiles. Common nucleophiles, such as alcohols, can react with the aldehyde group of 3 - bromo - 4 - pyridyl formaldehyde under acidic or basic catalytic conditions to form acetal products. This reaction not only helps to protect the aldehyde group, but also is often a key step in the design of organic synthesis routes, used for the construction of specific structures or the preparation of intermediates.
Furthermore, 3-bromo-4-pyridyl formaldehyde can participate in the oxidation reaction. The aldehyde group can be oxidized to the corresponding carboxylic acid. Common oxidants, such as potassium permanganate, manganese dioxide, etc., can make the aldehyde group undergo such transformation. However, due to the presence of the pyridine ring, the oxidation reaction conditions may be different from ordinary fatty aldose or aromatic aldehyde, and the reaction conditions need to be precisely controlled to obtain the ideal product.
And its bromine atom also exhibits significant reactivity. Bromine atom can be used as a leaving group to participate in nucleophilic substitution reaction. When encountering suitable nucleophiles, such as amines, alkoxides, etc., bromine atoms can be replaced, thereby introducing different functional groups at the third position of the pyridine ring. This property provides an effective way to synthesize pyridine derivatives with diverse structures. The pyridine ring itself is aromatic, and the electron cloud distribution is different from that of the ordinary benzene ring. The presence of nitrogen atoms makes the electron cloud density on the ring uneven, which affects the regioselectivity of the substitution reaction.
In addition, 3-bromo-4-pyridine formaldehyde can also participate in the condensation reaction. For example, with compounds with active methylene, condensation occurs under alkali catalysis to form products containing double bonds. Such reactions play an important role in the construction of conjugated system compounds. Many materials with special optical and electrical properties are often involved in the synthesis process of this type of reaction.
In summary, 3-bromo-4-pyridyl formaldehyde has become a valuable synthetic block in organic synthetic chemistry due to its unique chemical properties of aldehyde groups, bromine atoms and pyridine rings, providing rich possibilities for the creation of new organic compounds.

The synthesis method of 3-bromo-4-pyridine formaldehyde is not detailed in the ancient book "Tiangong Kaiwu", but based on today's chemical knowledge, there can be various ways.
First, pyridine is used as the starting material. Appropriate substitution reaction of pyridine is carried out first, and an aldehyde group is introduced. Pyridine can be co-heated with N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl) by Vilsmeier-Haack reaction. In this reaction, DMF interacts with POCl to form an active intermediate, attacking a specific position on the pyridine ring to form 4-pyridine formaldehyde. After that, under suitable conditions, the 3-position of the pyridine ring is brominated. A brominating agent, such as N-bromosuccinimide (NBS), can be used to react in a suitable solvent in the presence of an initiator such as benzoyl peroxide (BPO) to obtain 3-bromo-4-pyridine formaldehyde.
Second, 4-methylpyridine is used as the starting material. First, methyl is oxidized to an aldehyde group. The commonly used oxidizing agents are potassium permanganate (KMnO), potassium dichromate (K ² Cr ² O), etc. Under suitable acid-base conditions, 4-pyridine formaldehyde can be obtained. Then, as mentioned above, 3-position bromination is performed with brominating reagents such as NBS to obtain the target product.
Third, 3-bromopyridine can also be synthesized by introducing an aldehyde group. Metal-organic reagents, such as Grignard reagent or lithium reagent, can be used to first react with 3-bromo-pyridine to form the corresponding metal-organic intermediate, and then react with suitable electrophilic reagents, such as N, N-dimethylformamide (DMF), so as to introduce the aldehyde group at the 4-position of the pyridine ring to obtain 3-bromo-4-pyridine formaldehyde.
Various synthesis methods have their own advantages and disadvantages, and need to be selected according to the actual availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the target product.

3-Bromo-4-pyridinecarboxaldehyde (3-bromo-4-pyridyl formaldehyde) is used in medicine, materials and other fields.
In the field of medicine, this is a key intermediate for the synthesis of many drugs. Due to its unique molecular structure, it can be chemically modified to access various functional groups to prepare compounds with specific pharmacological activities. For example, it can be converted into drug molecules that target certain tumor cells through specific reaction pathways. Because tumor cells grow very differently from normal cells, such modified drug molecules can precisely act on specific targets of tumor cells, inhibit their proliferation, and achieve the effect of treating tumors. < Br >
In the field of materials, its applications are also quite extensive. First, it can be used to prepare fluorescent materials. 3-Bromo-4-pyridyl formaldehyde reacts with specific reagents to generate substances with fluorescent properties. Such fluorescent materials are widely used in the field of biological imaging, and can label specific molecules or cells in organisms to help researchers observe the microstructure and physiological processes in organisms. Second, 3-bromo-4-pyridyl formaldehyde is also indispensable in the preparation of organic semiconductor materials. After a series of chemical reactions, organic semiconductors with specific electrical properties can be constructed, which can be used in devices such as organic Light Emitting Diodes (OLEDs) and organic field effect transistors (OFETs) to improve the performance and efficiency of such devices.
Furthermore, in the field of fine chemicals, 3-bromo-4-pyridyl formaldehyde can be used as a raw material for the synthesis of special fragrances or additives. Due to its unique chemical structure, the reaction can endow the product with a special aroma or specific physical and chemical properties, such as improving product stability and enhancing its antioxidant properties.

Wen Jun inquired about the market price of "3 - Bromo - 4 - pyridinecarboxaldehyde", which is a fine chemical raw material, and its price fluctuates for a variety of reasons.
First, the cost of raw materials, the starting materials required to make "3 - Bromo - 4 - pyridinecarboxaldehyde", if the source is scarce, difficult to obtain, or the price changes due to changes in season, origin, supply and demand, the price of "3 - Bromo - 4 - pyridinecarboxaldehyde" will also fluctuate. < Br >
Second, the preparation is difficult and easy. If the synthesis of this compound requires complicated steps, harsh conditions, or relies on rare catalysts and special equipment, the production cost will rise and its price will be high.
Third, the market supply and demand situation, if many industries, such as pharmaceutical research and development, materials science, etc., have a surge in demand for "3-Bromo-4-pyridinecarboxaldehyde", and the supply is limited, the price will rise; on the contrary, if the demand is low and the supply is excessive, the price will be depressed.
Fourth, the manufacturers are different. Each factory has different costs and pricing due to the advantages and disadvantages of technology, scale, and management. Famous factories may have slightly higher prices due to their excellent quality and comprehensive after-sales service; new factories may be expanding the market, and the price may be close to the people.
Generally speaking, in the chemical raw material market, the price per gram may range from tens of yuan to hundreds of yuan. If you want to know the accurate market price, you need to consult chemical product suppliers in detail, or refer to the latest quotations from professional chemical trading platforms to get the exact number.

3-Bromo-4-pyridyl formaldehyde is also an organic compound. Its storage is essential to the quality and safety of this substance.
The choice of the first environment. It should be stored in a cool place, because the temperature is too high, or its chemical properties are unstable, causing decomposition and deterioration. And it must be dry. If it is in a humid place, water vapor is easy to interact with the compound, or react with hydrolysis, which will damage its purity.
The choice of containers. When using a sealed device to prevent excessive contact with air. Oxygen in the air may cause oxidation; carbon dioxide, etc., may also be changed with it. It is better to use glass or specific plastic containers. However, it is necessary to consider its compatibility with the compound and avoid the reaction between the container material and the compound.
Furthermore, keep away from fire and heat sources. This material may be flammable. In case of open fire or hot topic, there is a risk of fire. Therefore, fireworks are strictly prohibited in the storage place, and heat sources should also be kept at a safe distance.
Also pay attention to the storage of other chemicals. Due to its chemical activity, if it coexists with incompatible chemicals, it may react violently, causing serious consequences such as explosion.
In short, the storage of 3-bromo-4-pyridyl formaldehyde requires careful selection of the environment, suitable containers, away from fire and heat, and separate storage with other substances, so as to ensure its quality and avoid safety risks.