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What are the physical properties of 3-Bromo-4-Nitropyridine N-Oxide?
3-Bromo-4-nitropyridine-N-oxide is one of the organic compounds. Its physical properties are particularly important, and it is related to the performance of this compound in various chemical processes and practical applications.
First of all, its appearance is mostly solid at room temperature and pressure. The color of this solid state is usually white-like to light yellow powder or crystal. The characterization of this color can help chemists in the preliminary identification.
As for the melting point, it is also a key physical property. After many experiments, its melting point is within a certain range. The value of this melting point is of great significance for the determination of the purity of the compound and the study of the phase transition. When the temperature rises near the melting point, the compound gradually changes from the solid state to the liquid state, and this transition follows the inherent law of the phase transition of substances.
In terms of solubility, 3-bromo-4-nitropyridine-N-oxide exhibits specific solubility in common organic solvents. In polar organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), it has certain solubility. Due to the molecular structure of the compound, there are intermolecular forces between the polar solvent molecules, such as hydrogen bonds, van der Waals forces, etc., so that the two can interact and dissolve. However, in non-polar organic solvents, such as n-hexane and cyclohexane, its solubility is very small. Due to the weak force between non-polar solvents and the molecules of the compound, it is difficult to overcome the interaction between the molecules of the compound, making it difficult to dissolve.
In addition, the density of the compound is also one of the physical properties. Although its exact density value may vary slightly due to different measurement conditions, it is roughly maintained within a certain range. The size of the density is an important consideration in the separation, purification and design of related chemical processes.
In conclusion, the physical properties of 3-bromo-4-nitropyridine-N-oxide, such as appearance, melting point, solubility, and density, are the basis for studying its chemical behavior and practical applications, and chemists can conduct in-depth chemical research and process design based on this.
3-Bromo-4-Nitropyridine the synthesis of N-Oxide
There are several ways to prepare 3-bromo-4-nitropyridine-N-oxide in ancient times. First, pyridine-N-oxide is used as the starting material, first nitrified and then brominated. When nitrified, pyridine-N-oxide can be heated with concentrated nitric acid and concentrated sulfuric acid, and at an appropriate temperature, the nitro group will be introduced into the pyridine ring. After the nitrification product is obtained, it is then reacted with brominating reagents such as bromine and phosphorus tribromide to obtain 3-bromo-4-nitropyridine-N-oxide. In this process, the nitrification step needs to be properly controlled at temperature to prevent excessive nitrification and by-products from clumping.
Second, 3-bromopyridine-N-oxide is used as the starting material and the target is prepared by nitrification. In this process, 3-bromopyridine-N-oxide reacts with the nitrifying reagent in a specific solvent, such as dichloromethane and acetic anhydride. The reaction temperature also needs to be accurately controlled, because it is related to the selectivity and yield of the reaction. If the temperature is too high, there is a risk of bromine atoms being replaced; if the temperature is too low, the reaction rate will be slow.
Or, with 4-nitropyridine-N-oxide as the basis, the bromination reaction is carried out. Select a suitable brominating agent, such as N-bromosuccinimide (NBS), in the presence of light or initiator, so that the bromine atom replaces the hydrogen at the 3 position of the pyridine ring. In this path, the light intensity or the amount of initiator have an impact on the reaction process. Too much light or too much initiator can easily cause the reaction to go out of control and generate unnecessary by-products. < Br >
There are many methods for preparing 3-bromo-4-nitropyridine-N-oxide, and each method has its own advantages and disadvantages. It depends on the actual situation, such as the availability of raw materials, the ease of control of reaction conditions, and the purity and yield of the product.
What are the main uses of 3-Bromo-4-Nitropyridine N-Oxide?
3-Bromo-4-nitropyridine-N-oxide, its use is quite important. In the field of organic synthesis, this compound is a key intermediate.
Because of its unique structure, bromine atoms coexist with nitro and pyridine-N-oxide structures, making it able to participate in many chemical reactions. Bromine atoms are highly active and can be combined with a variety of nucleophiles through nucleophilic substitution reactions. For example, they can react with nucleophiles such as alcohols and amines to form new carbon-oxygen, carbon-nitrogen and other chemical bonds, and then synthesize a series of organic compounds with special structures and functions.
Furthermore, the presence of nitro groups also affects the activity and selectivity of the reaction. Nitro is a strong electron-absorbing group, which can reduce the electron cloud density on the pyridine ring, making the pyridine ring more vulnerable to attack by nucleophiles. At the same time, the nitro group can be reduced under appropriate conditions and converted into other functional groups such as amino groups, thus further expanding the application path of this compound in the synthesis of complex organic molecules.
The structure of pyridine-N-oxide also gives this compound unique reaction characteristics. It can modify and modify the pyridine ring through specific reactions to generate various pyridine derivatives.
In the field of medicinal chemistry, with this raw material, ingeniously designed and synthesized routes, compounds with potential biological activities can be created for the development of new drugs. In the field of materials science, the organic compounds involved in the synthesis may have unique photoelectric properties, which show potential for application in the preparation of organic optoelectronic materials. In short, 3-bromo-4-nitropyridine-N-oxide has important uses in many fields such as organic synthesis, drug development, and materials science due to its unique structure.
3-Bromo-4-Nitropyridine the market price of N-Oxide
I look at what you are asking, but I am inquiring about the market price of 3-bromo-4-nitropyridine-N-oxide. However, it is not easy to clarify its price. The price of this compound often changes due to multiple reasons.
First, the situation of supply and demand is the main reason. If there are many people in the market for this product, and there are few people in supply, the price will increase. On the contrary, if the supply exceeds the demand, the price may drop. And its application field also has an impact. If the demand in the pharmaceutical, chemical and other industries increases greatly, the price will fluctuate accordingly.
Second, the difficulty of preparation is related to the price. The synthesis of 3-bromo-4-nitropyridine-N-oxide may require delicate processes and specific raw materials. If the raw materials are scarce or the preparation process is complicated, the cost will be high and the price will be expensive. If the raw materials require difficult steps to obtain, or the purification is not easy, the cost will rise.
Third, market competition also affects its price. If there are multiple suppliers competing in the city, in order to compete for customers, or reduce their prices to attract buyers. However, if there is no competition, the supplier may set a higher price.
Fourth, the price varies from region to region. Different places, due to differences in transportation costs, tax policies, etc., prices also vary. In remote places, due to inconvenience in transportation, cost increases, and prices may be higher than those in passageways.
Viewed from the perspective of "Tiangong Kaiwu", the price of everything is intertwined by many factors. Although the specific price of 3-bromo-4-nitropyridine-N-oxide cannot be determined, it is known that there are traces of changes in its price. To know the exact price, you may need to check the market dynamics carefully, consult the supplier, or refer to the relevant transaction records to obtain a more accurate number.
3-Bromo-4-Nitropyridine N-Oxide in storage and transportation
3-Bromo-4-nitropyridine-N-oxide is a chemical substance. During storage and transportation, many things need to be paid attention to to ensure safety and quality.
First, when storing, find a cool, dry and well-ventilated place. This is because the substance is in a high temperature environment or chemically reacts due to temperature changes, resulting in quality deterioration; if the environment is humid, water vapor is easy to interact with the substance, which also affects its properties. Good ventilation can prevent the accumulation of harmful gases and avoid potential dangers.
Second, keep away from fire and heat sources. This chemical may be flammable or in contact with fire sources can easily cause violent reactions, causing the risk of fire or explosion. Therefore, fireworks are strictly prohibited in the storage place, and electrical equipment should also meet the standards of fire and explosion prevention.
Third, it should be stored separately from oxidants, reducing agents, acids, bases, etc. Because of its active chemical properties, it encounters or reacts chemically with the above various substances. Such reactions may be very violent and endanger safety.
Fourth, during transportation, it is necessary to ensure that the packaging is complete and sealed. Prevent the leakage of the material. If it leaks outside, it will not only waste materials, pollute the environment, but also pose a threat to people or objects in contact.
Fifth, the operator should be professionally trained to be familiar with the characteristics of the substance and emergency treatment methods. During transportation and storage, in case of emergencies, such as leakage, fire, etc., the operator can follow what he has learned, deal with it quickly and correctly, and minimize the harm.
In short, the storage and transportation of 3-bromo-4-nitropyridine-N-oxide is related to safety and quality. It is necessary to operate in strict accordance with specifications in all aspects, with caution and no slack.
