3-Bromo-4-methoxypyridine

3-Bromo-4-methoxypyridine is an organic compound with unique chemical properties. In its structure, the bromine atom and the methoxyl group are respectively connected to the specific position of the pyridine ring, and this structure endows it with various chemical activities.
From the perspective of reactivity, the bromine atom has a high activity and is often a check point for nucleophilic substitution reactions. Due to its electronegativity difference, the bromine atom is easily attacked by nucleophilic reagents. Nucleophilic reagents such as alkoxides and amines can replace bromine atoms to form new compounds. This reaction is commonly used in the construction of complex organic molecular structures.
Methoxy groups have electron-giving effects, which can affect the electron cloud density of the pyridine ring, so that the electron cloud density of the pyridine ring and the para-position increases relatively. Therefore, in the electrophilic substitution reaction, the reaction check point is more inclined to the methoxy o-position and the para-position. For example, when reacting with electrophilic reagents such as halogenated reagents, electrophilic reagents are more likely to attack the methoxy o-position.
In addition, the pyridine ring itself is weakly basic, and the lone pair electrons on the nitrogen atom can combine with acids to form salts. This property is of great significance in the fields of organic synthesis and medicinal chemistry, and can be used to adjust the solubility and stability of compounds. 3-Bromo-4-methoxypyridine is widely used in the field of organic synthesis. Due to its unique chemical properties, it can be used as a key intermediate to construct various organic compounds through various reactions. It has important applications in drug development, materials science and many other fields.

3-Bromo-4-methoxypyridine is also a compound commonly used in organic synthesis. The common synthesis methods are roughly as follows.
First, 4-methoxypyridine is used as the starting material. First, 4-methoxypyridine is interacted with a suitable brominating agent, such as bromine (Br ²) or N-bromosuccinimide (NBS). If bromine is used, it is often necessary to react in a suitable solvent, such as dichloromethane, at a certain temperature and in the presence of a catalyst. The catalyst can be selected from iron powder or iron tribromide, etc., and its function is to promote the substitution of bromine atoms to specific positions on the pyridine ring. During this reaction, due to the electron cloud distribution characteristics of the pyridine ring, bromine atoms tend to be substituted at the 3rd position, so that 3-bromo-4-methoxy pyridine can be obtained.
Second, a suitable pyridine derivative can also be used as the starting material, and the methoxylation reaction is carried out first, and the methoxy group is introduced into the 4th position of the pyridine ring. In this step, a suitable methoxylation reagent, such as iodomethane (CH
), can be used to react with a suitable base, such as potassium carbonate (K < unk > CO < unk >), in a suitable solvent, such as N, N-dimethylformamide (DMF). After the methoxy group is successfully introduced, the bromination reaction is carried out, just as the above bromination reagent is used to bromide the 3-position under suitable conditions, and the final product can also be obtained 3-bromo-4-methoxypyridine.
Third, some more complex multi-step reaction paths can also be passed. For example, first construct the basic skeleton of the pyridine ring, and reserve suitable functional groups that can introduce methoxy and bromine atoms. Through a series of reactions, such as nucleophilic substitution, redox, etc., methoxy and bromine atoms are gradually introduced to specific 4 and 3 positions of the pyridine ring to achieve the synthesis of 3-bromo-4-methoxy pyridine. However, this path often requires fine reaction design and condition control to ensure the smooth progress of each step of the reaction and the selectivity of the product.

3-Bromo-4-methoxypyridine is used in various fields such as medicinal chemistry and materials science.
In the field of medicinal chemistry, it is a key intermediate for the synthesis of many drugs. Due to its unique chemical structure, it can participate in a variety of chemical reactions to build complex drug molecular structures. For example, by reacting with specific reagents, different functional groups can be introduced to synthesize compounds with specific pharmacological activities. Such compounds may act on specific targets in the human body and show therapeutic potential for diseases such as inflammation and tumors. Some studies have shown that compounds synthesized on this basis may have inhibitory effects on the proliferation of some cancer cells, opening up new avenues for the development of anti-cancer drugs.
In the field of materials science, 3-bromo-4-methoxypyridine has also attracted much attention. Due to its structural properties, it can be applied to the preparation of organic optoelectronic materials. In the field of organic Light Emitting Diode (OLED), with appropriate modification, it may optimize the luminescent properties of materials, improve the luminous efficiency and stability. In the exploration of solar cell materials, it can also adjust the energy level structure of materials by virtue of its chemical properties, improve the absorption and conversion efficiency of light energy, and contribute to the development of new high-efficiency solar cell materials.
In addition, in the field of organic synthetic chemistry, it often participates in various catalytic reactions as a substrate. With the help of transition metal catalysis and other means, it can realize the coupling reaction with different organic reagents, expand the structural diversity of organic molecules, provide an effective strategy for the synthesis of complex organic compounds, and promote the development of organic synthetic chemistry.

The market price of 3-bromo-4-methoxypyridine is difficult to draw a conclusion. This is because the market price is often influenced by many factors and changes rapidly, just like the vagaries of the situation.
The first to bear the brunt is the cost of production. The price fluctuations of raw materials and the difficulty of the synthesis process all have a great impact on the cost. If raw materials are scarce and expensive, or the synthesis steps are complicated and harsh, and a lot of manpower, material and financial resources are required, the cost will rise and the price of the product will rise.
Furthermore, the relationship between supply and demand in the market is also key. If the market demand for this product is strong, but the supply is relatively insufficient, just like the scarcity of rain in a thirsty place, the price will rise; on the contrary, if the market demand is low and the supply is excessive, like a flood, the price will be under pressure.
In addition, the brand reputation and product quality of the manufacturer also affect the price. Well-known manufacturers, with their exquisite craftsmanship and strict quality control, produce high-quality products, even if the price is high, they may be favored by customers; while some unknown manufacturers, the quality of their products is uneven, in order to seek sales, or can only compete at low prices.
Looking at past market conditions, although it is difficult to find an exact price trajectory, according to the experience and relevant information of industry insiders, the price of 3-bromo-4-methoxypyridine may range from tens to hundreds of yuan per gram. However, this is only a rough estimate, and the actual price depends on specific transaction scenarios, purchase quantities, market conditions and other factors. To know the exact price, it is necessary to consult the relevant chemical product suppliers in detail before obtaining it.

3-Bromo-4-methoxypyridine is also a chemical substance. The storage conditions are crucial and related to the quality and properties of this substance.
Cover 3-bromo-4-methoxypyridine is sensitive to light, heat and humidity, and is easy to change. Therefore, when storing, it should be placed in a cool place, away from direct light, and the temperature should not be high, so as to prevent it from being decomposed by heat. Generally speaking, the storage temperature should be controlled between 2-8 ° C. This cold temperature can keep its chemical stability.
It is also sensitive to moisture, and moisture can easily cause its quality to be inferior. It must be stored in a dry place, or in a moisture-proof device, such as a sealed glass bottle with a built-in desiccant to prevent moisture from invading.
And this chemical may be toxic and corrosive, and the storage device must be corrosion-resistant and tightly sealed to prevent leakage and endanger humans, animals and the environment. When stored, it should also be separated from other things, especially avoid coexisting with oxidizing and reducing substances to avoid unexpected reactions.
In short, 3-bromo-4-methoxypyridine must be stored in a cool and dry place, controlled at 2-8 ° C, sealed with corrosion resistance, and separated from others, so as to maintain its purity and stability for future use.