3-Bromo-4-(hydroxymethyl)pyridine

3-Bromo-4- (hydroxymethyl) pyridine is a crucial intermediate in organic synthesis. It has a wide range of uses and can be used in the field of medicinal chemistry to create a variety of drugs. For example, it can become a key raw material for the synthesis of specific bioactive compounds. By modifying and transforming its structure, it can obtain drug molecules that have curative effects on specific diseases.
In the field of materials science, it also shows potential value. It can be used as a basic structural unit for the construction of special functional materials. With its unique chemical properties, it can endow materials with properties such as good optical properties, electrical properties or thermal stability.
In organic synthetic chemistry, 3-bromo-4- (hydroxymethyl) pyridine is often used as a reaction substrate to participate in various chemical reactions, such as nucleophilic substitution reactions, coupling reactions, etc. Through these reactions, different functional groups can be introduced, expanding the structural complexity of molecules, and laying the foundation for the synthesis of more complex organic compounds. In short, due to the activity of bromine atoms and hydroxymethyl groups in its structure, it is an indispensable chemical substance in many fields, which is of great significance for promoting scientific research and technological development in various related fields.

The synthesis of 3-bromo-4- (hydroxymethyl) pyridine has always been an important topic in organic synthesis. Past research has developed several feasible methods.
One of them can be started from 4-methylpyridine. First, the methyl of 4-methylpyridine is brominated with an appropriate brominating reagent, such as N-bromosuccinimide (NBS), under the condition of light or the presence of an initiator, to obtain 4-bromomethylpyridine. In this step, attention should be paid to the control of the reaction temperature and the amount of reagent to avoid excessive bromination. Subsequently, the obtained 4-bromomethylpyridine is hydrolyzed under mild conditions, such as treatment with a dilute alkali solution, and the bromine atom is replaced by a hydroxyl group to obtain 3-bromo-4- (hydroxymethyl) pyridine.
Second, pyridine-4-formaldehyde can also be used as the starting material. Bromine atoms are introduced at the third position of the pyridine ring through a bromination reaction. For this bromination process, suitable brominating agents and catalysts can be selected to precisely control the reaction check point. Next, the aldehyde group is reduced, and an isothermal reducing agent such as sodium borohydride is used to react in an appropriate solvent to convert the aldehyde group into hydroxymethyl groups, so as to achieve the synthesis of 3-bromo-4- (hydroxymethyl) pyridine.
Furthermore, starting from the pyridine derivative, the target product can also be obtained through multi-step functional group conversion. Appropriate protective groups are first introduced to protect the specific functional groups on the pyridine ring from being affected in subsequent reactions. Then the reaction steps such as bromination and hydroxymethylation are carried out in sequence, and finally the protective groups are removed to obtain pure 3-bromo-4- (hydroxymethyl) pyridine. Although this method is a little complicated, it can better control the regional selectivity and chemical selectivity of the reaction.
The above methods have their own advantages and disadvantages. In actual synthesis, it is necessary to carefully select the appropriate synthesis path according to the availability of raw materials, the difficulty of controlling reaction conditions, the requirements of yield and purity, and many other factors.

3-Bromo-4- (hydroxymethyl) pyridine, this compound is an organic compound. Looking at its structure, it contains bromine atoms, hydroxymethyl groups and pyridine rings. This unique structure gives it different physical properties.
In terms of its physical state, under normal temperature and pressure, it is mostly in the state of white to light yellow crystalline powder, just like fine jade, delicate and pure. This state is easy to store and use, and it is convenient for all kinds of experiments and industrial operations.
Its melting point range is about 95-99 ° C. When the temperature gradually rises, to the range, this substance is like ice and snow when it is warm, and it slowly melts from the solid state to the liquid state. This melting point characteristic is crucial for identification and purification.
Solubility is also a key physical property. It has a certain solubility in common organic solvents, such as methanol, ethanol, and dichloromethane, just like fish entering water and melting leisurely. In methanol, a uniform and transparent solution can be formed, which provides the possibility of selecting a variety of reaction media in organic synthesis reactions. In water, the solubility is relatively limited, only slightly soluble, such as thin clouds in the sky, only a little integration is seen.
When talking about the boiling point, although the exact value varies depending on the specific measurement conditions, it is generally in a higher temperature range. Under high temperature, it transforms from liquid to gaseous state, and this boiling point characteristic is an important basis in the separation and purification process.
In addition, the density of 3-bromo-4- (hydroxymethyl) pyridine is slightly larger than that of water, and it slowly settles when placed in water, like a stone sinking to the bottom. Its smell is slightly organic, although it is not rich and pungent, it can be detected under the smell of its unique charm.
These physical properties are interrelated and together outline the physical appearance of 3-bromo-4- (hydroxymethyl) pyridine, which is a cornerstone in many fields such as organic chemistry research and drug synthesis. It helps researchers and producers better control this substance and contributes to the development of various fields.

3-Bromo-4- (hydroxymethyl) pyridine is an organic compound. When storing, many aspects need to be paid attention to.
First, temperature and humidity have a significant impact. This compound should be stored in a cool and dry place. If the temperature is too high, it may change its chemical reaction activity and even cause decomposition; if the humidity is too high, it is easy to absorb moisture, which may interfere with its purity and stability. If it is hot and humid in summer, pay more attention to the regulation of the storage environment to prevent deterioration.
Second, light should not be ignored. The substance should be stored away from light because it may be sensitive to light, and photochemical reactions may occur under light, causing structural changes and quality damage. Therefore, the storage container should be made of dark materials such as brown bottles to block the invasion of light.
Third, the sealing must be good. The storage container should be tightly sealed to prevent contact with the air. Oxygen, carbon dioxide and other components in the air, or react with them, such as oxygen or oxidation, carbon dioxide may affect its pH, and ultimately affect the chemical properties.
Fourth, isolated storage is also critical. Do not mix with oxidants, acids, alkalis and other substances. Because of its active chemical properties, contact with these substances, or cause violent chemical reactions, such as redox, acid-base neutralization, etc., resulting in dangerous conditions, such as heat, explosion, etc.
Fifth, it is indispensable to do a good job of marking. The storage place should clearly indicate the name, specification, storage date and other information of the compound, which is convenient for tracking and management, timely understanding of its storage status, reasonable use within the valid period, and avoidance of experimental or production deviations due to expired use.
In summary, proper storage of 3-bromo-4- (hydroxymethyl) pyridine requires attention to temperature, humidity, light, sealing, isolation and identification to ensure its quality and stability.

3 - Bromo - 4 - (hydroxymethyl) pyridine is a kind of organic compound. Its market price is often volatile due to various factors.
The first to bear the brunt is the fluctuation of raw material prices, which have a huge impact on costs. The synthesis of this compound requires specific starting materials. If the raw material is scarce or its price rises and falls due to supply and demand imbalance, the price of 3 - Bromo - 4 - (hydroxymethyl) pyridine will also fluctuate.
Furthermore, the difficulty of the synthesis process also affects its market price. If the preparation method is complicated, multiple steps are required and the yield is not high, or special reaction conditions or expensive catalysts are required, the production cost will increase and the price will rise.
The supply and demand situation of the market is the key influencing factor. If there is strong demand for it in many industries, such as pharmaceutical research and development, materials science and other fields, and the supply is relatively insufficient, the price will rise; on the contrary, if the demand is weak and the supply is excessive, the price will inevitably decline.
In addition, the price varies depending on the region. In different places, the price varies due to different logistics costs, tax policies, and the degree of market competition. In areas with developed industries and intense competition, the price may be more reasonable; in remote or underdeveloped markets, the price may be higher.
To determine its accurate market price, it is necessary to carefully check the latest quotations of chemical product trading platforms, consult merchants specializing in chemical raw materials, or refer to recent market survey reports. The price of this compound is not static and needs to be studied according to the situation.