3-Bromo-4-chloro-1H-pyrrolo[3,2-c]pyridine

3 - Bromo - 4 - chloro - 1H - pyrrolo [3,2 - c] pyridine is an organic compound with unique chemical properties. It contains bromine and chlorobihalogen atoms, which have a significant impact on its chemical activity. Bromine and chlorine atoms have strong electronegativity, which enhances molecular polarity, making the compound easier to participate in various chemical reactions.
The structures of pyridine and pyrrole in this compound endow it with aromaticity. The aromatic compounds are stable in nature and can participate in electron transfer reactions through the π electron system. Due to the conjugation effect of pyridine and pyrrole ring, the electron cloud is delocalized in the entire molecular structure, which improves the molecular stability and also affects its reactivity and selectivity.
In nucleophilic substitution reactions, the bromine and chlorine atoms of 3-Bromo-4-chloro-1H-pyrrolo [3,2-c] pyridine are potential targets for nucleophiles. Because halogen atoms can be used as leaving groups, nucleophiles can attack the carbon atoms connected to them to achieve substitution reactions. Since the electronegativity of bromine and chlorine atoms is different from the leaving ability, the reaction selectivity will be affected. Generally speaking, the leaving ability of bromine atoms is stronger than that of chlorine atoms, and under appropriate reaction conditions, bromine atoms are more likely to be replaced by nucleophiles.
The compound may also participate in metal-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc. In these reactions, after complexing with metal catalysts, halogen atoms in the molecular structure can be coupled with organometallic reagents to form carbon-carbon bonds, providing an effective way to construct complex organic molecular structures.
From the perspective of physical properties, due to molecular polarity and the presence of halogen atoms, 3-Bromo-4-chloro-1H-pyrrolo [3,2-c] pyridine has better solubility in organic solvents than water. However, the specific solubility is also affected by factors such as temperature and solvent type. Its melting point and boiling point are also closely related to the intermolecular forces, which in turn depend on the molecular polarity and structural accumulation mode.
In summary, 3 - Bromo - 4 - chloro - 1H - pyrrolo [3,2 - c] pyridine is rich in chemical properties and has a wide range of uses in the field of organic synthesis. It can construct a variety of organic compound structures through various reactions, providing a key foundation for organic chemistry research and drug synthesis.

The common synthesis methods of 3-bromo-4-chloro-1H-pyrrolido [3,2-c] pyridine are important in the field of chemical synthesis. One method is to introduce bromine and chlorine atoms through halogenation reaction with compounds containing pyridine structure as starting materials. Among them, suitable pyridine derivatives can be carefully selected first, and under specific reaction conditions, a suitable bromination reagent, such as N-bromosuccinimide (NBS), in a suitable solvent, such as dichloromethane, under a certain temperature and catalytic conditions, the pyridine ring is brominated at a specific position to precisely locate the substitution check point of bromine atoms.
After the bromination step is properly completed, the chlorination reaction is carried out. Select a suitable chlorination reagent, such as phosphorus oxychloride (POCl <) or sulfonyl chloride (SO < Cl <), adjust the reaction temperature, time and ratio of the reactants, so that the chlorine atom is replaced to the target position as expected, and the key structure of 3-bromo-4-chloro-1H-pyrrolido [3,2-c] pyridine is achieved.
Another method can start from the parent of pyrrolido [3,2-c] pyridine, first introduce chlorine atoms, and then introduce bromine atoms. Appropriate chlorination reagents are selected to achieve the substitution of chlorine atoms at the appropriate check point in the pyridine ring in a suitable reaction system. Then, according to the bromination reaction mechanism, appropriate brominating agents and reaction conditions are selected to complete the introduction of bromine atoms, and the selectivity and yield of the reaction are paid attention to to avoid excessive side reactions and impure products.
In addition, the reaction involving organometallic reagents can also be a synthetic route. Under the action of specific catalysts, the target molecular structure is constructed by coupling reaction between organometallic reagents with pyridine or pyrrolido-pyridine structures, such as Grignard reagents or lithium reagents, and halogenated hydrocarbons containing bromine and chlorine. This process requires precise control of the reaction conditions to ensure the activity and stability of the metal reagent, in order to achieve efficient and highly selective synthesis.

3-Bromo-4-chloro-1H-pyrrolido [3,2-c] pyridine is widely used in the field of medicine. Due to its unique structure and diverse biological activities, it can serve as a key intermediate in drug development.
Looking at the creation of anti-tumor drugs, which can interact with specific targets, or interfere with the proliferation and apoptosis-related signaling pathways of tumor cells, or affect tumor angiogenesis, it is expected to become the cornerstone of new anti-tumor drugs. And it also shows potential in the development of drugs for neurological diseases. Due to its ability to modulate the transmission of neurotransmitters and the activity of receptors, it provides new therapeutic ideas and approaches for neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
In the field of pesticides, 3-bromo-4-chloro-1H-pyrrolido [3,2-c] pyridine is also useful. Its biological activity can be used to develop new insecticides and fungicides. For example, it targets the nervous system or metabolic pathways of specific pests to achieve the purpose of efficient insecticide; or inhibits the growth and reproduction of pathogens, adding a powerful means for crop pest control.
Furthermore, in the field of materials science, its unique structure endows molecules with special electrical and optical properties. Or it can be used to prepare organic semiconductor materials and applied to devices such as organic Light Emitting Diodes (OLEDs) and organic field effect transistors (OFETs) to improve the performance and function of devices and inject new vitality into the development of materials science.

3 - Bromo - 4 - chloro - 1H - pyrrolo [3,2 - c] pyridine is an organic compound whose physical properties are crucial for many chemical applications.
The properties of this substance are mostly solid under normal conditions. Due to the intermolecular force, the molecules are arranged in an orderly manner to form a relatively stable solid-state structure. Its melting point is also an important physical property. Although there is no exact literature to calibrate the specific value, it can be inferred that the melting point is higher than that of some simple pyridine compounds due to the presence of halogen atoms such as bromine and chlorine in the molecule, which increases the intermolecular force. The electronegativity of the halogen atom is large, which will enhance the van der Waals force between molecules and the dipole-dipole interaction, so a higher energy is required to break the lattice structure and melt the substance.
In terms of solubility, since the compound contains nitrogen heterocycles and halogen atoms, it has a certain polarity. In polar organic solvents, such as methanol, ethanol, etc., it may have a certain solubility. Due to the formation of hydrogen bonds and dipole-dipole interactions between polar solvent molecules and the compound molecules, the solubility may be low in non-polar solvents, such as n-hexane and benzene. Due to the weak intermolecular force between the non-polar solvent and the polar compound, it is difficult to overcome the intermolecular force of the compound and disperse it in the solvent.
In addition, its appearance may be white to light yellow solid, and the generation of color may be related to electronic transitions in the molecular structure. The presence of conjugated systems and halogen atoms will affect the absorption and reflection of light by molecules, and then exhibit specific colors.
The density of this substance, although there is no clear data, it can be inferred that its density is greater than that of water based on the structure containing heavy atoms bromine and chlorine. The relative atomic mass of bromine and chlorine atoms increases the mass of the substance per unit volume, resulting in higher density than water.
In summary, the physical properties of 3-Bromo-4-chloro-1H-pyrrolo [3,2-c] pyridine, such as solid state properties, high melting point, specific solubility, appearance color, and relatively high density, are closely related to its molecular structure, which is of great significance for its application in chemical synthesis, drug development, and other fields.

3-Bromo-4-chloro-1H-pyrrolido [3,2-c] pyridine is a chemical substance. Its market price often fluctuates due to many factors and is difficult to determine.
bear the brunt, and the cost of raw materials for preparing this compound has a significant impact. If the raw materials required for its synthesis are scarce, difficult to obtain, or the preparation process is complicated, special reagents and catalysts are required, the cost will be high, and the final product price will rise. For example, if the required raw materials need to be synthesized through multiple steps, the yield and purity of each reaction will affect the cost, which will then affect the market price.
Furthermore, the relationship between market supply and demand also affects its price. If there is a strong demand for this substance in many industries at a certain time, such as pharmaceutical companies developing specific drugs to increase their demand, and the supply is limited, the supply is in short supply, and the price will go up. On the contrary, if the market demand is low and the supply is excessive, the price will fall.
In addition, production technology and process level also play a role. Advanced and efficient production technology can improve yield, reduce energy consumption and costs. If an enterprise masters advanced technology, its products may have an advantage in market pricing. On the contrary, the technology is backward, the cost is difficult to drop, and the price will also be affected.
Quality Standards are also critical. High-purity, high-quality products require stricter production control and purification processes, and the cost is higher, and the price is naturally higher than that of ordinary quality products.
Prices in different regional markets also vary. In developed regions, prices may be higher due to factors such as operating costs and tax policies; in developing regions, costs are relatively low and prices may be more affordable.
To know the exact market price, you can consult chemical reagent suppliers, chemical product trading platforms, or inquire from relevant industry experts and business people to obtain accurate and real-time price information.