3 Bromo 2 Trifluoromethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

3-Bromo-2-(trifluoromethyl)pyridine

    Specifications

    HS Code

    365563

    Name 3-Bromo-2-(trifluoromethyl)pyridine
    Molecular Formula C6H3BrF3N
    Molecular Weight 226.00
    Appearance Liquid (predicted)
    Boiling Point 165 - 166 °C
    Density 1.716 g/mL at 25 °C
    Refractive Index 1.472
    Flash Point 62.8 °C
    Solubility Soluble in organic solvents like dichloromethane
    Purity Typically high - purity products are 95%+
    Cas Number 84526-23-0

    As an accredited 3-Bromo-2-(trifluoromethyl)pyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing
    Storage
    Shipping
    Free Quote

    Competitive 3-Bromo-2-(trifluoromethyl)pyridine prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615365036030 or mail to info@alchemist-chem.com.

    We will respond to you as soon as possible.

    Tel: +8615365036030

    Email: info@alchemist-chem.com

    General Information
    Where to Buy 3-Bromo-2-(trifluoromethyl)pyridine in China?
    As a trusted 3-Bromo-2-(trifluoromethyl)pyridine manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3-Bromo-2-(trifluoromethyl)pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 3-Bromo-2- (trifluoromethyl) pyridine?
    3-Bromo-2- (trifluoromethyl) pyridine is widely used in the field of organic synthesis. It can be used as a key intermediate to produce a variety of fluorine-containing heterocyclic compounds. Such compounds are of great value in the fields of medicine, pesticides, and materials science.
    In the creation of medicine, based on this, drugs with special physiological activities can be synthesized. Due to the introduction of fluorine-containing groups, the lipid solubility, metabolic stability, and biological activity of compounds can be changed. For example, after a specific reaction, it can be combined with other functional groups to obtain highly selective and efficient therapeutic drugs for specific diseases, and may have important applications in the development of anti-cancer and antiviral drugs.
    In the field of pesticides, 3-bromo-2- (trifluoromethyl) pyridine is used as the starting material. After a series of reactions, fluorinated pesticides can be obtained with high efficiency and low toxicity. Fluorinated pesticides often have strong insecticidal, bactericidal and herbicidal activities, and have good environmental compatibility, which can meet the needs of modern agriculture for green and efficient pesticides.
    In the field of materials science, fluorine-containing heterocyclic polymers or functional materials synthesized from them may have unique electrical, optical and thermal properties. For example, in organic optoelectronic materials, such fluorinated compounds can optimize the carrier transport performance of materials, improve luminous efficiency, and contribute to the development of organic Light Emitting Diode (OLED), solar cells and other fields. In conclusion, 3-bromo-2- (trifluoromethyl) pyridine is an indispensable synthetic building block in many important fields due to its unique structure and reactivity, which is of great significance for promoting the progress of related industries.
    What are the synthesis methods of 3-Bromo-2- (trifluoromethyl) pyridine
    3-Bromo-2 - (trifluoromethyl) pyridine is an important intermediate in organic synthesis. There are many different synthesis methods, each has its own advantages and disadvantages, try to describe it in detail.
    One method is to use 2 - (trifluoromethyl) pyridine as the starting material and obtain it by bromination reaction. First dissolve 2 - (trifluoromethyl) pyridine in a suitable solvent, such as dichloromethane, and slowly add a brominating agent, such as N-bromosuccinimide (NBS), dropwise at low temperature. This reaction needs to be protected by inert gas and protected from light to ensure the smooth progress of the reaction. After the reaction is completed, the pure product can be obtained by extraction, washing, drying, column chromatography and other steps. The advantage is that the starting materials are easy to purchase, and the reaction conditions are relatively mild; however, the disadvantages are also obvious, there are many side reactions, and the yield is not high.
    There is another method, using a suitable pyridine derivative as the substrate, first introducing trifluoromethyl, and then brominating. For example, the pyridine derivative is first reacted with a trifluoromethylation reagent, such as trifluoromethyl magnesium halide, under specific conditions, to form a pyridine intermediate containing trifluoromethyl, and then the target product is prepared by the bromination step. This path can effectively control the position of the substituent and has good selectivity; however, the reagents used may be more expensive, and the synthesis step is slightly more complicated, and the cost increases.
    Another method is synthesized by metal-catalyzed trifluoromethylation reaction using halogenated pyridine as raw material. Halogenated pyridine, trifluoromethylation reagents and metal catalysts, such as palladium catalysts, are placed in a suitable reaction system, assisted by alkali, to heat up the reaction. This method can efficiently construct carbon-trifluoromethyl bonds with the help of metal catalyst activity; however, the reaction equipment and conditions are relatively high, and catalyst recovery and reuse are also considered.
    All synthesis methods have advantages and disadvantages. Experimenters should choose according to their own conditions, such as raw material availability, cost budget, equipment status, etc., in order to efficiently synthesize 3-bromo-2- (trifluoromethyl) pyridine.
    What are the physical properties of 3-Bromo-2- (trifluoromethyl) pyridine
    3-Bromo-2- (trifluoromethyl) pyridine is a very important compound in the field of organic synthesis. Its physical properties are as follows:
    Looking at its appearance, under normal temperature and pressure, it mostly appears as a colorless to light yellow liquid. This color characteristic is a sign of its significance.
    When talking about the boiling point, it is usually at 170-172 ° C under specific conditions. The property of boiling point plays a key guiding role for the separation and purification of this compound. Because of knowing its boiling point, the temperature can be adjusted reasonably to achieve effective separation.
    In terms of melting point, it is about -35 ° C. The value of the melting point affects the physical state of the substance at different temperatures. Below the melting point, it exists as a solid; above the melting point, it transforms into a liquid state.
    The density of this compound is about 1.72 g/cm ³. This parameter of density is of great significance in many chemical operations. For example, when it comes to liquid-liquid separation, or when calculating its mass in a specific volume, density data is indispensable.
    Its solubility is also worthy of attention, and it can be soluble in common organic solvents such as dichloromethane, chloroform, ether, etc. This solubility property provides a wide range of possibilities for the selection of solvents in organic synthesis reactions. Due to different reactions, the requirements for solvents vary, and good solubility is conducive to the smooth progress of the reaction.
    In addition, 3-bromo-2- (trifluoromethyl) pyridine has a certain volatility and can evaporate slowly in the air. During operation, attention should be paid to the fact that its volatilization may affect the experimental environment and may also have a potential impact on the health of operators.
    In summary, the many physical properties of 3-bromo-2- (trifluoromethyl) pyridine have important application value in the fields of organic synthesis, analysis and testing, providing an important reference for relevant scientific researchers to carry out their work.
    What to pay attention to when storing and transporting 3-Bromo-2- (trifluoromethyl) pyridine
    3-Bromo-2- (trifluoromethyl) pyridine is an important reagent commonly used in organic synthesis. When storing and transporting, many matters need to be carefully paid attention to.
    When storing, the first choice of environment. This compound should be stored in a cool, dry and well-ventilated place. Due to high temperature and humidity, it is very easy to induce its chemical changes and cause its deterioration. For example, if it is in a high temperature and humid place, bromine atoms may react with surrounding water molecules, causing the structure of the compound to be damaged. Therefore, choosing a place with constant temperature and suitable humidity is the key to storage.
    Furthermore, the material of the storage container is also crucial. When using corrosion-resistant containers, such as glass or specific plastic materials. This is because 3-bromo-2 - (trifluoromethyl) pyridine contains halogen atoms and fluoromethyl groups, which have certain chemical activity and can chemically react with ordinary metal materials, thereby corroding the container and causing the risk of leakage.
    When transporting, safety protection is the first priority. Be sure to ensure that the packaging is tight to prevent package damage due to vibration and collision. The packaging of this compound should be able to withstand a certain external impact before it can be intact during transportation.
    And the environmental conditions of the means of transportation should also be strictly controlled. Appropriate temperature and humidity must be maintained, and it must not be exposed to extreme weather. If the transportation is in a hot summer and the temperature inside the vehicle is too high, the compound may decompose due to heat; if it is in a cold winter, the temperature is too low, or its physical state may change, affecting the quality.
    In addition, during transportation, relevant regulations and operating procedures must be strictly followed. This compound may be among the hazardous chemicals, and transporters must be familiar with its characteristics and emergency treatment methods to prevent accidents from happening and respond quickly to minimize harm.
    What is the market price of 3-Bromo-2- (trifluoromethyl) pyridine?
    I look at the market price of 3 - Bromo - 2 - (trifluoromethyl) pyridine, a key intermediate in the field of fine chemicals, which is widely used in medicine, pesticides, materials and other industries. However, its market price often fluctuates due to various factors, just like the situation changes, and it is difficult to be constant.
    The first to bear the brunt is the change in the price of raw materials. If the price of bromide, fluorinated raw materials, etc. required for the preparation of this compound fluctuates, it will affect the price of the final product. If the price of bromine increases due to scarcity of resources and limited production, the cost of this compound will also increase, and the market price will rise.
    Furthermore, the advantages and disadvantages of the production process. Advanced and efficient processes can reduce energy consumption, increase productivity, and thus cut costs. If a factory develops a unique and innovative process that can significantly reduce production costs, it will have an advantage in market pricing. Those with backward processes have high costs and difficult prices.
    The relationship between supply and demand in the market is also key. If the pharmaceutical industry has a large increase in demand for drugs containing this structure, or the research and development of new formulas in the pesticide field requires a large amount of this intermediate, the demand is strong and the supply is limited, the price will rise. On the contrary, if the market is saturated and the supply is excessive, the price will be under pressure.
    Regional factors should not be ignored. Prices vary in different regions due to differences in transportation costs, tax policies, and market competition. In prosperous cities, demand is concentrated, competition is fierce, and prices may become more reasonable; in remote places, transportation is inconvenient, costs are superimposed, and prices may be high.
    Overall, its market price is difficult to generalize. To know the exact price, it is necessary to carefully observe the market dynamics of raw materials, pay attention to the process innovation of production enterprises, understand the supply and demand pattern of the industry, and communicate closely with relevant suppliers and distributors to grasp its price context.