3-BROMO-2-METHYL-5-(TRIFLUOROMETHYL)PYRIDINE

3-Bromo-2-methyl-5- (trifluoromethyl) pyridine, an organic compound, has important uses in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. Through organic synthesis, it can be converted to construct molecular structures with specific biological activities. In the process of many drug development, such pyridine derivatives containing specific substituents need to be used to obtain drug molecules with high affinity and selectivity for specific targets. For example, in the synthesis of some antibacterial drugs and anti-tumor drugs, this compound may be used as a starting material or a key reaction intermediate to help build the core skeleton. After a series of reactions, various functional groups are added to achieve the expected pharmacological activity.
In the field of materials science, it also has applications. Due to its properties of fluorine atoms, it can endow materials with unique properties. Fluorinated organic compounds often have good thermal stability, chemical stability and low surface energy. Introducing this compound into the structure of polymer materials may lead to the preparation of materials with special properties, such as high-performance coatings, special plastics, etc. These materials may demonstrate advantages in fields that require strict material properties, such as aerospace and electronics industries.
In the field of pesticide chemistry, it also plays an important role. Pyridine compounds are often important components of pesticide active ingredients. This compound may be chemically modified to develop new pesticides, which have efficient control effects on pests and bacteria. Its unique structure may endow pesticides with good biological activity, selectivity and environmental compatibility, providing an effective means for pest control in agricultural production.
In summary, 3-bromo-2-methyl-5- (trifluoromethyl) pyridine is an important basic raw material in the fields of medicine, materials, and pesticides. With its special structure, it provides opportunities for innovation and development in various fields.

The synthesis of 3-bromo-2-methyl-5- (trifluoromethyl) pyridine has been recorded in the ancient books. One method is to introduce bromine atoms through halogenation reaction with compounds containing pyridine structure as starting materials. In a suitable reaction vessel, dissolve the starting material into a suitable organic solvent, such as dichloromethane or tetrahydrofuran, cool to a suitable temperature, usually between 0 ° C and room temperature, slowly add a brominating reagent, such as N-bromosuccinimide (NBS), and add an appropriate amount of initiator, such as azobisisobutyronitrile (AIBN), under the protection of inert gas, when stirring the reaction number, the process needs to be closely monitored, and the reaction endpoint can be determined by thin layer chromatography (TLC). After the reaction is completed, the bromine-containing pyridine intermediate can be obtained through extraction, washing, drying, column chromatography and other steps.
Then, the intermediate is methylated. The intermediate is placed in another reactor, a strong base such as sodium hydride (NaH) is added, and the activation is stirred at low temperature, and then a methylation reagent such as iodomethane (CH 🥰 I) is added. The reaction temperature is controlled between 0 ° C and 50 ° C. After continuous stirring, the methyl group is successfully introduced into the designated position. After the reaction is completed, it undergoes post-processing operations, including extraction, washing, vacuum distillation, etc., to obtain the target product precursor.
Finally, the introduction of trifluoromethyl is realized. The precursor is reacted with a trifluoromethylation reagent, such as sodium trifluoromethanesulfonate (CF < unk > SO < unk > Na), in a suitable solvent, such as N, N < unk > -dimethylformamide (DMF), and an appropriate amount of catalyst, such as copper salt (CuI) and ligand, under heating conditions, the temperature is about 80 ° C to 120 ° C, and the reaction lasts for a few days. After the reaction is completed, the pure product of 3-bromo-2-methyl-5 - (trifluoromethyl) pyridine can be obtained by regular separation and purification methods, such as column chromatography, recrystallization, etc. Although the steps of this synthesis path are complex, the reaction conditions of each step are relatively mild and the yield is considerable, making it an effective synthesis method for the compound.

3-Bromo-2-methyl-5- (trifluoromethyl) pyridine, this is an organic compound, its physical properties are very important, related to its application in the field of chemistry.
First words appearance, under normal temperature and pressure, it is often colorless to light yellow liquid, pure color, uniform texture, quite fluid in appearance, under light, or shimmering refraction, just like smart water, but it has unique chemical properties.
When it comes to boiling point, it is about a specific temperature range. This property makes it possible to separate from other substances according to the difference in boiling point in separation operations such as distillation. The boiling point is the critical temperature at which a substance changes from liquid to gaseous state, which is of great significance for its treatment in chemical processes. When the temperature rises to the boiling point, the molecule obtains enough energy to break free from the liquid phase and escape into the gas phase, thereby achieving separation or purification.
The melting point is also a key physical property. Although the specific value may vary slightly due to factors such as impurities, it is roughly within a certain range. The melting point is the temperature at which a solid state changes to a liquid state, which determines its physical form under a specific environment. At low temperatures, it may be in a solid state, with a stable structure and orderly arrangement of molecules; when the temperature rises to the melting point, the lattice structure disintegrates, and the molecules gain more free movement space, and then turn into a liquid state.
The density is the mass per unit volume, and the density of 3-bromo-2-methyl-5- (trifluoromethyl) pyridine is specific. This property is crucial in solution preparation, mixing and other operations. When substances of different densities are mixed, they may be stratified due to density differences, or mixed uniformly, which affects the reaction process and product distribution.
The solubility cannot be ignored. It may have good solubility in organic solvents, such as common ethanol and ether, but it may have limited solubility in water. This property is based on the principle of similarity and miscibility. Polar organic solvents are close to the polarity of the compound and easily interact with each other to form a uniform system. Although the polarity of water is strong, it is very different from the structure of the compound, so the solubility is poor. This solubility affects the feasibility and rate of chemical reactions in different solvents.

3-Bromo-2-methyl-5- (trifluoromethyl) pyridine, this is an organic compound. Its chemical properties are unique and valuable for investigation.
First of all, its halogenation reaction characteristics. Bromine atoms are significantly active in this compound. When encountering nucleophiles, bromine atoms are easily replaced. For example, when co-heating with alcohols in an alkaline environment, anions of alcohol and oxygen act as nucleophiles, which can replace bromine atoms to generate corresponding ether derivatives. This reaction provides an effective path for the construction of carbon-oxygen bonds and is widely used in the field of organic synthesis.
Let's talk about the reaction of methyl groups. Although the methyl group at the 2-position is relatively stable, it can be oxidized under the action of strong oxidants. For example, when reacted with strong oxidants such as potassium permanganate, methyl groups can be gradually oxidized to carboxyl groups. This process can realize the conversion of functional groups and lay the foundation for the synthesis of pyridine derivatives containing carboxyl groups.
Trifluoromethyl has a significant impact on this compound. Because of its strong electron absorption, it not only affects the electron cloud distribution of the molecule, but also reduces the electron cloud density on the pyridine ring. This results in a decrease in the activity of the electrophilic substitution reaction of the pyridine ring, and a selective change in the reaction check point. For example, in the electrophilic substitution reaction, the substituents tend to enter the position where the electron cloud density is relatively
In addition, the compound can also participate in metal-catalyzed coupling reactions. With the help of palladium, nickel and other metal catalysts, it can be coupled with borate-containing esters, halogenated hydrocarbons and other reagents to realize the construction of carbon-carbon bonds, providing the possibility for the synthesis of complex organic molecules. These unique chemical properties make it show broad application prospects in many fields such as medicinal chemistry and materials science.

There are 3-bromo-2-methyl-5- (trifluoromethyl) pyridine available today. I would like to know how its price is in the market. However, the price in the market changes rapidly and is subject to various factors, such as origin, purity, supply and demand, and purchase quantity.
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And purity is also the key to the price. 3-Bromo-2-methyl-5- (trifluoromethyl) pyridine of high purity is difficult to prepare and expensive, and the price is more expensive than that of ordinary purity.
In short, in order to know the exact market price, it is necessary to inquire more and comprehensively consider various factors to obtain a more accurate price.