3-Bromo-2-methoxypyridine

3-Bromo-2-methoxypyridine is also an organic compound. It has a wide range of uses and is often a key synthesis intermediate in the field of medicinal chemistry.
When creating new drugs, this compound has a significant effect. Due to its unique structure, it can introduce different functional groups through various chemical reactions, and then construct a complex molecular structure with specific pharmacological activities. For example, in the synthesis process of some antibacterial drugs, 3-bromo-2-methoxypyridine can be used as a starting material. By undergoing nucleophilic substitution reactions with other nitrogen-containing and oxygen-containing compounds, it carefully builds the core skeleton of the drug molecule, giving the drug the ability to inhibit or kill specific bacteria. < Br >
In the field of materials science, it also has its uses. It can participate in the preparation of materials with special optoelectronic properties. Due to the presence of bromine and methoxy groups, it can affect the electron cloud distribution and conjugation system of the material, thereby regulating the properties of light absorption, emission and charge transport of the material. For example, in the research and development of organic Light Emitting Diode (OLED) materials, structural modification and derivatization based on 3-bromo-2-methoxy pyridine is expected to prepare luminescent materials with high luminous efficiency and long life, which will contribute to the development of OLED display technology.
In addition, in the field of pesticide chemistry, it is also an important synthetic building block. It can be used to synthesize a variety of high-efficiency, low-toxicity and environmentally friendly pesticides. By combining with different active groups, pesticide products with high selectivity and biological activity against specific pests or weeds are created, which contributes to the sustainable development of agriculture and ensures the yield and quality of crops.

To make 3-bromo-2-methoxypyridine, there are several common methods. First, it can be started from 2-methoxypyridine. Shilling 2-methoxypyridine with brominating reagents, such as bromine, under appropriate reaction conditions. This reaction requires careful temperature control. Generally, it can be carried out at low temperatures, such as between 0 ° C and 5 ° C, in suitable solvents, such as dichloromethane. During the reaction, due to the electron cloud distribution characteristics of the pyridine ring, the bromine atom will be mainly replaced in the third position. However, in this process, it is necessary to pay attention to the activity of the pyridine ring. If the temperature is too high or there is too much bromine, or the by-products of polybromination are generated.
Second, the pyridine ring can be properly activated or protected first, and then brominated. For example, the nitrogen atom of 2-methoxypyridine is first protected with a suitable protective group, such as acylating reagents, such as acetic anhydride, to generate N-acetyl-2-methoxypyridine. The electron cloud distribution of this derivative has changed, which is more conducive to 3-position bromination. After the bromination is completed, the protective group can be removed through appropriate deprotection steps to obtain the target product.
Furthermore, 2-hydroxypyridine can also be used as a raw material. Shilling it with methylating reagents, such as dimethyl sulfate, in the presence of a base, to obtain 2-methoxypyridine. Then according to the above bromination method, 2-methoxypyridine is brominated to obtain 3-bromo-2-methoxypyridine. Each method has its advantages and disadvantages. The actual preparation needs to be based on the availability of raw materials, the difficulty of reaction, yield and purity requirements, and many other factors should be considered carefully.

3-Bromo-2-methoxypyridine is also an organic compound. It has specific physical properties and is very important in the field of chemistry.
First, its appearance is usually a colorless to light yellow liquid or crystalline solid, depending on the conditions. Its melting point is about 27-31 ° C. This temperature characteristic makes its state change within a specific temperature range, which has a certain impact on its storage and transportation.
Furthermore, its boiling point is about 224-226 ° C. The level of the boiling point reflects the strength of the intermolecular force. A higher boiling point indicates that the intermolecular force is relatively large. In the process of separation and purification, appropriate temperature conditions need to be selected accordingly to achieve the purpose.
The density of 3-bromo-2-methoxypyridine is about 1.52 g/mL. This density value helps to accurately calculate the dosage by measuring the volume or mass in actual operation. It is crucial for the material ratio of chemical reactions.
In terms of solubility, it is slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, chloroform, etc. This solubility characteristic provides a basis for selecting the appropriate reaction medium in the organic synthesis reaction. The presence of organic solvents can promote the dissolution and contact of the reactants, thereby accelerating the reaction process.
In addition, its vapor pressure and volatility are also important properties. Although the specific value varies depending on the conditions, in general, its volatility is relatively moderate. This property is related to its diffusion in the air during production, storage and use, and has an impact on the safety of the operating environment and product stability.
In summary, the many physical properties of 3-bromo-2-methoxypyridine are of great significance for applications in organic synthesis, drug development, and other fields, helping chemists to more accurately control related chemical reactions and processes.

The market price of 3-bromo-2-methoxypyridine is difficult to say in a word. Its price is influenced by many factors, like a changing situation and complex.
The first to bear the brunt is the production process. If the preparation method is exquisite and efficient, the raw material loss is low, and the yield is quite high, the cost is controllable, which is also beneficial to the market price. On the contrary, if the process is cumbersome and costly, the price will rise.
Furthermore, the situation of raw material supply also plays a crucial role. If the raw material sources are extensive and the supply is stable, the price may be stable. However, if the raw materials are scarce, difficult to obtain, or the supply is suddenly reduced due to natural and man-made disasters, geopolitics, etc., the price will be like a runaway horse and skyrocket.
Market demand is also the key. If this compound is in strong demand in the fields of medicine, pesticides, materials, etc., and the supply is in short supply, merchants will raise the price to make a profit. On the contrary, if demand is low and supply exceeds demand, prices will come under pressure.
In addition, regional differences also affect prices. In different places, prices may vary due to differences in economic level, logistics costs, and policies and regulations.
Looking at the past market, the price of 3-bromo-2-methoxypyridine often fluctuates within a certain range. However, to know the exact current price, you must visit chemical raw material suppliers, trading platforms, and consult market dynamics in detail to obtain accurate figures. The market is constantly changing, and only by closely tracking it can you obtain its true situation.

For 3-bromo-2-methoxypyridine, all precautions must be carefully considered during storage and transportation. This is due to its chemical properties, which is also related to safety and quality.
For storage, the first choice of environment. It should be placed in a cool, dry and well-ventilated place. Because shade can slow the rate of chemical change, drying can avoid moisture intrusion, and ventilation can prevent the accumulation of harmful gases. If it is placed in a high temperature, humid place, or causes material deterioration, it will damage its quality.
In addition, storage containers must also be carefully selected. Use corrosion-resistant, well-sealed containers. Due to its certain chemical activity, ordinary materials or reactions with them can cause damage to the container and leakage of substances. And the seal can prevent contact with outside air and moisture to ensure its chemical stability.
As for transportation, it is essential to protect securely. Make sure that the packaging is firm to prevent damage to the container due to vibration and collision. The transportation vehicle should also be equipped with suitable temperature control and ventilation devices to maintain the stability of temperature and humidity during transportation.
In addition, the operator should also be familiar with its characteristics and emergency treatment methods. In case of accidents such as leakage, it can be dealt with quickly and in accordance with regulations to minimize harm. All of these are important points that must be taken into account when storing and transporting 3-bromo-2-methoxypyridine, and should not be ignored.