3-Bromo-2-isopropoxypyridine

3-Bromo-2-isopropoxypyridine is an important chemical substance in the field of organic synthesis. It has a wide range of uses and plays a key role in many chemical synthesis reactions.
The primary use lies in the field of pharmaceutical synthesis. This compound is often a key intermediate for the preparation of various drugs. Because of its unique structure, it can combine with other functional groups through a series of chemical reactions to construct complex molecular structures with specific pharmacological activities. For example, it can be used to synthesize drugs with antibacterial, anti-inflammatory and other effects. By chemically modifying it, the activity and selectivity of drugs can be precisely regulated to meet the needs of different disease treatments.
Furthermore, in the field of materials science, 3-bromo-2-isopropoxypyridine also has important applications. It can participate in the preparation of organic materials with special properties, such as photovoltaic materials. By cleverly designing the reaction path and connecting it with other conjugated systems, it can endow the material with unique optical and electrical properties, such as fluorescence properties, charge transport ability, etc., which can be applied to the fabrication of advanced materials and devices such as organic Light Emitting Diodes (OLEDs) and solar cells.
In addition, in the methodological research of organic synthetic chemistry, 3-bromo-2-isopropoxypyridine is often used as a substrate to explore novel reaction mechanisms and synthesis strategies. Chemists have developed more efficient and green organic synthesis methods by studying their reactivity, promoting the development of organic chemistry.
In summary, 3-bromo-2-isopropoxypyridine has indispensable and important uses in many fields such as medicine, materials and organic synthesis methods due to its unique structure and reactivity, and has made great contributions to the development of modern chemical science and related industries.

There are several common methods for synthesizing 3-bromo-2-isopropoxypyridine.
First, 2-hydroxypyridine is used as the starting material. First, 2-hydroxypyridine is brominated, and bromine atoms can be introduced at the third position of the pyridine ring. For this bromination reaction, suitable brominating reagents can be selected, such as liquid bromine under appropriate catalysts and reaction conditions. After 3-bromo-2-hydroxypyridine is obtained, it is reacted with isopropylating reagents. The isopropylation reagent can be selected from isopropyl halide, such as isopropyl bromide or isopropyl chloride. In the presence of a base, a nucleophilic substitution reaction occurs. The base can be selected from potassium carbonate, etc., and the reaction is heated in a suitable organic solvent. In this way, 3-bromo-2-isopropoxypyridine can be prepared.
Second, 2-halopyridine is used as the starting material. If 2-chloropyridine or 2-bromo-pyridine is selected, it is first brominated at 3-position, and the operation is similar to the above. After that, the 2-position halogen atom is replaced with isopropoxy. At this time, 2-halo-3-bromopyridine can be mixed with isopropoxy and a base. The base prompts isopropoxy to form isopropoxy negative ions, and then undergoes nucleophilic substitution with the 2-position halogen atom of pyridine. Commonly used bases such as sodium hydride are reacted in a suitable reaction system to obtain the target product.
Third, synthesized by the construction of pyridine derivatives. First construct a pyridine ring containing isopropoxy and bromine atoms. For example, under suitable reaction conditions, a suitable enamine or enol ether compound and a reagent containing bromine and isopropoxy are cyclized to form a pyridine ring, and the target substituent is introduced at the same time. Such reactions often require specific catalysts and reaction environments to ensure the selectivity and yield of the reaction.

3-Bromo-2-isopropoxypyridine is one of the organic compounds. Its physical properties are particularly important, and it is related to the behavior of this compound in various chemical processes and practical applications.
First of all, its appearance, under normal temperature and pressure, is mostly colorless to light yellow liquid. This color state is easy to observe and is also its initial characterization in a specific scene.
The boiling point is about 230-235 ° C. The boiling point is the critical temperature at which a substance changes from liquid to gas. This value shows that 3-bromo-2-isopropoxypyridine needs to reach such a high temperature before it can boil and vaporize. This property is crucial in separation and purification operations such as distillation, and can help chemists accurately control the temperature to separate the compound from others.
The value of the melting point is about -10 ° C. The melting point is the temperature at which a substance changes from a solid state to a liquid state. This low-temperature melting point indicates that the compound is not easy to solidify under a relatively normal temperature environment and often exists in a liquid state.
In terms of density, it is about 1.31 g/cm ³. Density reflects the mass of a substance per unit volume. This value allows us to know that it is heavier than water. In systems involving liquid-liquid mixing or stratification, its density characteristics determine its location and distribution in the system.
Solubility is also an important physical property. 3-Bromo-2-isopropoxypyridine is soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility gives it the ability to mix well with many reactants in organic synthesis reactions and promote the progress of the reaction. However, its solubility in water is not good. In the process of separation and purification, this characteristic can be achieved by means of separation of aqueous and organic phases. Purification purposes are achieved.
Vapor pressure should also not be ignored. Although the vapor pressure is low at room temperature, when the temperature rises, the vapor pressure will also increase accordingly. This property is related to the volatility of the compound, which affects its behavior in confined spaces or high temperature environments, and is of great significance for the setting of storage and use conditions.
In summary, the physical properties of 3-bromo-2-isopropoxypyridine, such as appearance, boiling point, melting point, density, solubility, and vapor pressure, are interrelated and together determine the way and characteristics of its synthesis, separation, storage, and application in the chemical field.

The market price of 3-bromo-2-isopropoxypyridine is difficult to say in a word. The price often fluctuates due to many factors.
The first to bear the brunt is the cost of raw materials. The preparation of this compound requires specific raw materials. If the supply of raw materials is blocked, or its price fluctuates due to market supply and demand, production area, policies and regulations, etc., the cost of 3-bromo-2-isopropoxypyridine will also be affected, and eventually its market price will change.
Furthermore, the quality of the production process is also related. A delicate and efficient production process can reduce costs, increase output, and then affect its selling price. If a manufacturer develops a unique and low-cost process, it will have an advantage in market pricing.
The situation of market supply and demand is also the key. If the demand for 3-bromo-2-isopropoxypyridine in many industries increases sharply, but the supply is limited, the price will rise; on the contrary, if the market is saturated and the demand is weak, the price will fall.
In addition, the uniqueness of the manufacturers also leads to price differences. Well-known big factories, because of their brand reputation and quality control, have higher product prices than ordinary manufacturers.
Therefore, in order to know the exact market price of 3-bromo-2-isopropoxypyridine, it is necessary to investigate the raw material market, production process progress, supply and demand dynamics, and pricing strategies of various manufacturers in real time to obtain more accurate price information.

3-Bromo-2-isopropoxypyridine is an important compound in organic chemistry. During storage and transportation, many points need to be paid attention to.
When storing, the temperature and humidity of the first environment should be the temperature and humidity. This compound should be stored in a cool and dry place to prevent its hydrolysis due to excessive humidity, or decomposition reaction caused by excessive temperature, resulting in quality damage. The temperature should generally be controlled below 25 ° C, and the humidity should be maintained below 60%.
Furthermore, it is necessary to pay attention to its sensitivity to light. 3-Bromo-2-isopropoxypyridine should be stored away from light because it is easy to cause photochemical reactions when exposed to light, resulting in structural changes and affecting performance. Therefore, the storage container should be dark and have a shading effect, such as brown glass bottles, and the warehouse lighting should also be moderately controlled to avoid direct exposure to strong light.
When storing, the sealing of the container is very important. This compound is easy to interact with oxygen and moisture in the air, so the storage container must be well sealed to prevent the intrusion of external substances. After each use, the container should be sealed again in time to prevent deterioration.
During transportation, safety is the top priority. 3-Bromo-2-isopropoxypyridine may be toxic and corrosive. When transporting, suitable packaging materials should be selected in accordance with relevant regulations. The packaging should be sturdy and can effectively prevent leakage. The outer packaging should be marked with clear warning labels, such as "toxic" and "corrosive", so that the transportation personnel can know and handle it properly.
The condition of the transportation vehicle should not be ignored. It should be ensured that the internal environment of the transportation vehicle is stable, the temperature and humidity are controllable, and severe vibration and turbulence are avoided. Vibration and turbulence may cause damage to the container and cause leakage accidents. At the same time, it is necessary to strictly avoid mixing with other substances that may react with it during transportation to prevent dangerous chemical reactions.
In conclusion, 3-bromo-2-isopropoxypyridine needs to be carefully considered in many aspects such as temperature and humidity, light protection, sealing and safety during storage and transportation, so as to ensure its quality and transportation safety.