3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine

The chemical properties of 3-bromo-2-hydroxy-5- (trifluoromethyl) pyridine are worth exploring. It has a halogenated pyridine structure and an active bromine atom. In the nucleophilic substitution reaction, it can be replaced by many nucleophilic reagents, such as alkoxides, amines, etc., to form novel compounds.
Hydroxy groups are acidic and can form salts with bases, and also involve reactions such as esterification and etherification. Trifluoromethyl, on the other hand, is a strong electron-absorbing group, which affects the distribution of electron clouds in the pyridine ring, causing the electron cloud density on the ring to decrease, making the electrophilic substitution reaction difficult, but making the nucleophilic substitution easier. < Br >
Due to its fluorine content, compounds have special physical and chemical properties, such as improved fat solubility and stability. In the field of organic synthesis, it can be used as a key intermediate to produce fluorinated drugs, pesticides and functional materials through various reaction paths.
Its stability varies with substituents. Trifluoromethyl enhances stability, but hydroxyl and bromine atoms increase some reactivity. In summary, 3-bromo-2-hydroxy-5- (trifluoromethyl) pyridine has rich chemical properties and has broad application prospects in many fields such as organic synthesis.

3-Bromo-2-hydroxy-5- (trifluoromethyl) pyridine is widely used in the field of organic synthesis.
First, it can be used as a pharmaceutical intermediate. The synthesis of many drugs depends on its participation, such as some compounds with specific biological activities. Because its structure contains halogen atoms, hydroxyl groups and trifluoromethyl groups, these groups endow it with unique reactivity and biological characteristics. Halogen atoms can be combined with other reagents containing specific functional groups through nucleophilic substitution reactions to construct complex molecular structures, which can help synthesize drugs with therapeutic effects on specific diseases.
Second, it is also of great value in the field of pesticide creation. The research and development of pesticides requires the creation of compounds with high insecticidal, bactericidal or herbicidal activities. The special structure of the pyridine derivative allows it to interact with specific receptors or enzymes in the target organism, exhibiting excellent biological activity. For example, by rationally designing the reaction, introducing specific groups to optimize their action mechanism against pests or pathogens, and then developing new and efficient pesticides.
Furthermore, in the field of materials science, there are also potential uses. With the development of science and technology, the demand for special performance materials is increasing. This pyridine compound can be used as a structural unit and introduced into polymer materials to endow the materials with special properties such as weather resistance and chemical stability. Due to the existence of trifluoromethyl, it can enhance the hydrophobicity and corrosion resistance of materials, and has potential application prospects in the modification of coatings, plastics and other materials.

To prepare 3-bromo-2-hydroxy-5- (trifluoromethyl) pyridine, the following method is often followed.
First take the raw material containing the pyridine ring, such as 5- (trifluoromethyl) pyridine-2-ol, and use it as the base to introduce the bromine atom at the 3rd position. Optional brominating agent, such as liquid bromine or N-bromosuccinimide (NBS). If liquid bromine is used, in a suitable solvent, such as dichloromethane, at low temperatures and in the presence of catalysts such as iron powder or iron tribromide, liquid bromine can be substituted with 5- (trifluoromethyl) pyridine-2-ol. Iron is first formed with bromine to form iron tribromide, which initiates bromine radicals, which are then substituted with hydrogen at the 3rd position of the pyridine ring to obtain the target.
If N-bromosuccinimide, benzoyl peroxide, etc. are used as initiators, and in an inert solvent, such as carbon tetrachloride, under heating or lighting conditions, NBS produces bromine free radicals, and the 3-position hydrogen of 5- (trifluoromethyl) pyridine-2-ol can also be obtained. 3-bromo-2-hydroxy-5- (trifluoromethyl) pyridine is separated and purified. It can be extracted with an organic solvent first, the reaction liquid is separated from the aqueous phase, and then by column chromatography, the appropriate silica gel is selected as the stationary phase, and the polar solvent in different proportions, such as the mixture of petroleum ether and ethyl acetate, is used as the mobile phase to separate the product, remove impurities, and finally obtain a pure 3-bromo-2-hydroxy-5- (trifluoromethyl) pyridine.

I don't know the market price of 3 - Bromo - 2 - hydroxy - 5 - (trifluoromethyl) pyridine. The price of this compound often varies due to many factors, and it is difficult to generalize.
First, the price of different manufacturers must be different. Large manufacturers may reduce costs by virtue of scale effect, and the price may be relatively close to the people; if small manufacturers produce exquisite technology, they may be able to price with characteristics. And the purity of products from different manufacturers is different, and the price of higher purity is higher or higher.
Second, the purchase quantity also affects the price. Bulk purchases, merchants may give preferential discounts for small profits but quick turnover; small purchases, the unit price may be higher.
Third, the market supply and demand relationship is the key. If the demand is strong and the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price will fall.
Fourth, the cost of raw materials and the complexity of the synthesis process also affect the price. If the raw materials are rare and the synthesis is difficult, the cost will be high, and the selling price will not be low.
Therefore, if you want to know the exact market price, you need to check the chemical product trading platform in detail, consult the supplier, or ask the industry to obtain more accurate price information.

3-Bromo-2-hydroxy-5- (trifluoromethyl) pyridine is a key intermediate in organic synthesis. During storage and transportation, special attention should be paid to many matters to prevent its deterioration or cause safety accidents.
When storing, the first choice of environment. This substance should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is more sensitive to heat, high temperature can easily cause decomposition or accelerate chemical reactions, which in turn affects its quality. The temperature of the warehouse should be maintained in an appropriate range, not too high. At the same time, it must be kept dry, due to humid environment or causing reactions such as hydrolysis. For example, if the ambient humidity is high, the hydroxyl group may interact with water and change the structure of the substance.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. This is because the chemical properties of 3-bromo-2-hydroxy-5- (trifluoromethyl) pyridine are active, and contact with the above substances may cause severe chemical reactions, or cause serious consequences such as fire and explosion.
Packaging is also crucial. Sealed packaging is required to prevent it from coming into contact with air. Oxygen or moisture in the air may react with it. Packaging materials should also be carefully selected to ensure that they do not chemically react with the substance to maintain its stability.
During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. When handling, it must be handled lightly to avoid package damage due to severe vibration and impact, resulting in material leakage. Transportation vehicles should also take protective measures and be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. During transportation, it should be protected from exposure to the sun, rain and high temperature. If transported in summer, special attention should be paid to avoid direct sunlight to prevent danger caused by excessive temperature.
In addition, transportation personnel also need to have professional knowledge, familiar with the characteristics of the substance and emergency treatment methods. In the event of an accident such as leakage, measures can be taken quickly and correctly to reduce the harm.