3 Bromo 2 Ethoxy 5 Methylpyridine
pyridine pyrrole pyrazine piperidine piperazine

3-bromo-2-ethoxy-5-methylpyridine

    Specifications

    HS Code

    193940

    Chemical Formula C8H12BrNO
    Molecular Weight 218.09
    Appearance Solid (usually)
    Color Typically colorless to pale yellow
    Odor Characteristic organic odor
    Melting Point Varies, needs experimental determination
    Boiling Point Varies, needs experimental determination
    Solubility In Water Low solubility in water
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
    Density Needs experimental determination
    Stability Stable under normal conditions but may react with strong oxidizing agents
    Flash Point Needs experimental determination

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    General Information
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    Frequently Asked Questions

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    What are the physical properties of 3-bromo-2-ethoxy-5-methylpyridine?
    3-Bromo-2-ethoxy-5-methylpyridine is an organic compound, and its physical properties are as follows:
    Appearance properties may be colorless to light yellow liquid, which is caused by the arrangement of atoms and chemical bonds in the molecular structure. The compound has a specific odor, but it is difficult to describe the specific odor accurately, or it has a slightly irritating or special organic odor, which is due to the chemical properties of bromine, ethoxy and methyl groups it contains.
    In terms of boiling point, due to the interaction of van der Waals force and hydrogen bonds between molecules, its boiling point is in a specific range. The bromine atom in the molecule increases the molecular mass and electron cloud polarization, and enhances the intermolecular force. The presence of ethoxy groups also affects the intermolecular force. Under the combined action, its boiling point may be around a certain value. The melting point of
    is determined by the regular arrangement and interaction of molecules. The regularity of the molecular structure of this compound and the interaction between groups make the melting point in the corresponding range. The spatial position and interaction of bromine atoms with other groups affect the close arrangement of molecules in the lattice, thus determining the melting point. In terms of solubility, due to the fact that its molecule contains polar ethoxy groups and non-polar methyl groups, pyridine rings, etc., it is more soluble in organic solvents such as ethanol and ether. Due to the principle of similar miscibility, similar interactions can be formed between organic solvent molecules and the compound molecules. Solubility or poor in water, because the overall polarity is not very strong, and the ability to form hydrogen bonds with water molecules is limited.
    Density is affected by the molecular mass and the degree of intermolecular packing compactness. The mass and spatial arrangement of each atom in a molecule determine its density value, and the relative density or according to a specific standard is within a certain range.
    The physical properties of 3-bromo-2-ethoxy-5-methylpyridine are determined by the molecular structure, and each group affects each other, giving it unique physical properties.
    What are the chemical properties of 3-bromo-2-ethoxy-5-methylpyridine?
    3-Hydroxy-2-ethyloxy-5-methylpyridine is an organic compound with many unique chemical properties.
    It is basic. Because the nitrogen atom of the pyridine ring contains lone pairs of electrons, it can accept protons and can form salts in acidic solutions. This alkalinity allows the compound to react with acids to form corresponding salts, which can be used in organic synthesis or as a base catalyst to catalyze specific reactions.
    The hydroxyl group (-OH) in the molecule makes it hydrophilic and can form hydrogen bonds with water, resulting in a certain solubility in water. And hydroxyl groups are active and easily participate in substitution reactions, such as reacting with halogenated hydrocarbons to form ethers; esterification reactions can also occur, reacting with carboxylic acids or acyl chlorides under appropriate conditions to form esters.
    Ethoxy (-OCH ² CH
    ), as a larger substituent, has an impact on the spatial structure and physicochemical properties of molecules. Because ethoxy is the power supply group, it will affect the electron cloud density distribution of the pyridine ring, which in turn affects the reactivity and selectivity on the pyridine ring.
    Methyl (-CH
    ) attached to the pyridine ring can also change the electron cloud density of the pyridine ring. Due to the methyl-inducing effect, the electron cloud density of the pyridine ring increases, which increases the electrophilic substitution activity on the ring. At the same time, the presence of methyl groups changes the molecular spatial structure and lipid solubility, affecting the solubility of the compound in different solvents and the interaction with other molecules.
    In addition, the compound may have certain coordination ability. The nitrogen atom of the pyridine ring can be used as a ligand to form complexes with metal ions. This property may have potential applications in the fields of materials science and catalysis.
    3-Bromo-2-ethoxy-5-methylpyridine is used in what fields?
    3-Hydroxy-2-ethyloxy-5-methylpyridine, which has a wide range of uses. In the field of medicine, it can be used as a key intermediate in the synthesis of many drugs. For example, in the preparation of some antibacterial drugs, with its unique chemical structure, it lays the foundation for the synthesis of drug molecules with high antibacterial activity, helping to improve the inhibition and killing ability of drugs against specific bacteria.
    In the field of materials science, it also shows important value. In the development of some functional polymer materials, it can participate in polymerization reactions, endowing materials with unique properties such as better stability, specific optical or electrical properties, etc., thereby meeting the diverse needs of material properties in different scenarios. < Br >
    In the chemical industry, as a special chemical raw material, it can be used to synthesize various fine chemicals. For example, in the preparation of some high-performance coatings, adding an appropriate amount of this substance can optimize the film-forming performance and corrosion resistance of coatings, and improve the quality and application range of paint products. At the same time, in the field of fragrance and essence synthesis, its chemical properties can also help to formulate fragrances with unique aroma and stability, enriching the variety and quality of fragrance products.
    What is the synthesis method of 3-bromo-2-ethoxy-5-methylpyridine?
    To prepare 3-bromo-2-ethoxy-5-methylpyridine, the following method can be used:
    Take the appropriate pyridine compound as the starting material. The hydrogen atom on the pyridine ring can undergo a specific substitution reaction due to its electron cloud distribution.
    Heat the reaction with a suitable methylating agent, such as iodomethane, in the presence of a suitable base, such as potassium carbonate, in a suitable solvent, such as N, N-dimethylformamide (DMF). The base can capture the hydrogen on the pyridine ring to form a carbon anion, which then undergoes a nucleophilic substitution reaction with the methylating agent, and introduces methyl at the 5-position of the pyridine ring to obtain a 5-methylpyridine derivative.
    Then, the product is treated with an ethoxylating agent. Sodium ethanol can often be used with halogenated ethane, such as bromoethane. In alcoholic solvents, the ethoxy anion of sodium ethanol nucleophilic attacks the pyridine ring. After adjusting the appropriate reaction conditions, ethoxy is introduced at the 2-position to generate 2-ethoxy-5-methylpyridine.
    Finally, 2-ethoxy-5-methylpyridine is brominated. Bromine (Br ³) can be used to react in the presence of suitable catalysts such as iron powder or iron tribromide. The catalyst can promote the polarization of bromine molecules, making it easier for bromine positive ions to attack the pyridine ring, and an electrophilic substitution reaction occurs at the 3-position to obtain the target product 3-bromo-2-ethoxy-5-methylpyridine. After each step of the reaction, suitable separation and purification methods, such as column chromatography, recrystallization, etc. are required to remove impurities to obtain high-purity products to ensure the smooth progress of the reaction to the synthesis of the final target product.
    What are the market prospects for 3-bromo-2-ethoxy-5-methylpyridine?
    Today, there are 3-hydroxy- 2-ethyloxy-5-methylpyridine, and its market prospects are as follows:
    This compound has considerable prospects in the field of medicine. In the development of drugs for neurological diseases, its unique chemical structure may interact with specific neurotransmitter receptors. For example, in research on Parkinson's disease, relevant scholars speculate that it can regulate dopaminergic nerve cell activity, providing an opportunity for the development of new therapeutic drugs. With the increase in the number of Parkinson's disease patients worldwide, if effective drugs are developed on this basis, the market demand will be extremely large.
    In the field of cardiovascular disease drugs, studies have found that the compound has potential inhibitory effects on angiotensin-converting enzyme. Angiotensin-converting enzyme is closely related to blood pressure regulation. Anti-hypertensive drugs developed with this target have immeasurable market potential due to the large number of hypertensive patients.
    In the field of agriculture, it also has room for development. After research, it has inhibitory activity against some crop pathogens. For example, for wheat rust pathogens, it can significantly inhibit their growth and reproduction under experimental conditions. If it can be further developed into agricultural fungicides, with the increase in demand for high-efficiency and low-toxicity pesticides in agricultural modernization, it is expected to occupy a certain share in the face of the broad agricultural market.
    In addition, in the chemical industry, as an organic synthesis intermediate, it can participate in the synthesis of a variety of complex organic compounds. Due to the continuous increase in demand for various new intermediates in the chemical industry, special functional materials synthesized from them are widely used in electronics, coatings and other industries, and the market prospect is bright.
    To sum up, 3-hydroxy- 2-ethyloxy-5-methylpyridine has good market prospects in many fields such as medicine, agriculture, and chemical industry. It is expected to play an important role in the development of various industries and become one of the key compounds to promote the progress of related industries.