3-bromo-2-cyanopyridine

3-Bromo-2-cyanopyridine is an important agent in organic synthesis. It has a wide range of uses and is widely used in the fields of medicinal chemistry, pesticide chemistry and material science.
In medicinal chemistry, it is a key intermediate for the synthesis of drugs. Due to its unique structure, it can be linked to other compounds through many chemical reactions to form molecules with specific pharmacological activities. For example, in the synthesis of antibacterial drugs, it can be used to introduce specific groups, so that the drug can accurately act on the target of bacteria and achieve antibacterial effect. In the development of anti-cancer drugs, it can be used as a starting material to construct complex molecular structures with anti-cancer activity through multi-step reactions, which will help to overcome cancer problems.
In the field of pesticide chemistry, 3-bromo-2-cyanopyridine is also indispensable. It can be used to create new pesticides. Pesticides synthesized based on it may have high insecticidal and bactericidal properties, and are environmentally friendly. It can reduce damage to the ecological environment while ensuring a bumper agricultural harvest. For example, synthetic insecticides can precisely act on the nervous system or physiological metabolic pathways of pests, causing death to pests, but have a slight impact on beneficial insects and environmental organisms.
In the field of materials science, it can participate in the preparation of functional materials. After chemical modification and polymerization, materials with special optical, electrical or mechanical properties can be prepared. For example, when used in the synthesis of photoelectric materials, its structure may make the material have excellent photoelectric conversion efficiency, which has potential application value in solar cells and other fields; or it may be used to prepare high-performance engineering plastics, improve the heat resistance, mechanical strength and other properties of the material, and expand the application range of materials.
In summary, 3-bromo-2-cyanopyridine is an important cornerstone in many scientific fields due to its unique structure and reactivity, promoting technological innovation and development in various fields.

3-Bromo-2-cyanopyridine is also an important intermediate in organic synthesis. The method of its synthesis has many advantages.
One method can be prepared by halogenation of 2-cyanopyridine. First, 2-cyanopyridine and brominating reagents, such as bromine (Br ²), are used under appropriate reaction conditions. In a suitable solvent, such as dichloromethane, and at a mild temperature or in a cooled state, bromine is slowly added dropwise. At the same time, a catalyst, such as iron powder or iron tribromide, can be added to promote the reaction. The bromine atom can selectively replace the hydrogen atom at the 3-position on the pyridine ring to obtain 3-bromo-2-cyanopyridine. This reaction requires careful monitoring of the reaction process to prevent the risk of excessive bromination.
There is another method, using a suitable pyridine derivative as the starting material, first introducing the cyanyl group on the pyridine ring, and then introducing the bromine atom. For example, a pyridine containing a suitable substituent can be prepared first, and the cyanide reaction can be carried out to connect the cyanide group to the 2-position of the pyridine ring. The cyanidation method can be carried out by using a cyanide reagent, such as potassium cyanide (KCN), in a suitable reaction system, or with the assistance of a phase transfer catalyst. Then, the bromination step is carried out to achieve the synthesis of 3-bromo-2-cyanopyridine. In this way, the reaction conditions of cyanide and bromide, such as temperature, solvent, and the ratio of reactants, need to be carefully controlled to obtain the ideal yield and purity.
In addition, there are also synthesis methods catalyzed by transition metals. Select suitable transition metal catalysts, such as palladium catalysts, to work synergistically with ligands. The 3-bromo-2-cyano group on the pyridine ring is constructed by coupling reaction with bromine and cyano-containing reagents. This method often requires strict control of the reaction conditions, and has high requirements for the anhydrous and anaerobic reaction environment. However, its selectivity is good, and it has many advantages in specific research and production scenarios.
The above synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively weigh the availability of raw materials, the difficulty of reaction, the requirements of yield and purity, and cost to choose the appropriate one.

3-Bromo-2-cyanopyridine is an organic compound with unique physical properties. Let me tell you in detail.
This substance is mostly solid at room temperature, but its specific physical form may be slightly different due to purity and environmental factors. Looking at its color, it is usually a white to light yellow solid powder with a fine texture and a slight luster when viewed under light.
When it comes to melting point, it is about a specific temperature range. This temperature is the critical value for the transformation of a substance from a solid state to a liquid state, which is of great significance for its purification and identification. Its melting point value is stable, reflecting the strength of intermolecular forces. If impurities are mixed in, the melting point may be deviated. < Br >
The boiling point is also a key physical property, which is the temperature at which a substance changes from a liquid state to a gaseous state. Under a specific pressure, the boiling point of 3-bromo-2-cyanopyridine is fixed, which is helpful for distillation separation and purification.
Solubility also needs attention, and its solubility varies in organic solvents. Common organic solvents such as ethanol, acetone, and dichloromethane may have a certain solubility. In ethanol, with the increase of temperature, the solubility may increase. Due to the increase of temperature, the thermal movement of molecules intensifies, and the interaction between solvent and solute molecules is enhanced. In water, because its structure contains hydrophobic pyridine rings and hydrophilic cyano and bromine atoms, the solubility is relatively limited, but it is not absolutely insoluble. A small amount can be dispersed in water to form a weak dispersion system. < Br >
In terms of density, there is a specific value. This property is related to its stratification in solution. When mixed with other liquids, its distribution position can be judged according to the density difference.
In addition, the physical properties of 3-bromo-2-cyanopyridine, such as vapor pressure and refractive index, are also of research value. Vapor pressure reflects the difficulty of volatilization, and refractive index can be used for purity detection and material identification. Many physical properties are interrelated, which helps researchers to understand their characteristics in depth and is widely used in organic synthesis, drug development and other fields.

3-Bromo-2-cyanopyridine is an organic compound with unique chemical properties and diverse reactivity.
It contains bromine atoms and cyanyl groups, both of which are active functional groups. Bromine atoms have high activity and can undergo nucleophilic substitution reactions. Under the action of bases, nucleophilic reagents such as alkoxides and amines can attack the carbon position of bromine atoms, and bromine ions leave to form new substitution products. For example, when reacted with sodium alcohol, corresponding ether compounds can be formed; when reacted with amines, nitrogen-containing substitution products are obtained. This reaction is widely used in the synthesis of nitrogen-containing heterocyclic compounds.
Cyanyl groups also have active chemical properties. Cyanyl groups can be hydrolyzed. Under acidic or basic conditions, cyanyl groups are gradually converted into amides, which in turn become carboxylic acids. For example, when an acidic aqueous solution is heated, an amide intermediate is formed first, and 3-bromo-2-pyridinecarboxylic acid is formed by continuing the reaction. Cyanyl groups can also participate in nucleophilic addition reactions, such as reaction with Grignard reagents. The carbon negative ions in Grignard reagents attack cyanocarbon and hydrolyze to obtain ketones. This is an important method for constructing carbonyl-containing compounds.
The bromine atom of 3-bromo-2-cyanopyridine interacts with the cyanyl group, making the activity of the two different from that when they exist alone. This combination of electronic and spatial effects determines the unique reactivity of the compound, providing rich possibilities for organic synthetic chemistry to prepare complex and functional organic compounds through various reaction paths.

The price of all kinds of things in the market often varies according to time, place, quality and supply and demand. As for 3-bromo-2-cyanopyridine, the price in the market is also uncertain.
In the past, the price of various chemical raw materials may vary depending on the distance of the place of origin, and the freight is high or low. If it is produced near a neighboring country and the transportation is convenient, the price may be slightly cheaper; if it comes from a distant place, the journey is long, and the freight is huge, the price will increase.
Furthermore, the purity of this thing is also the key to pricing. If the purity is high, the preparation must be refined, and the materials used must be good, so the price is high; if the purity is low, the preparation method may be simple, the materials used or miscellaneous, and the price is slightly inferior.
In addition, the supply and demand of the market also affect its price. If there are many people who need it at a time, but there are few producers, the supply exceeds the demand, and the price will jump; on the contrary, if the production is profitable, the demand is thin, and the supply exceeds the demand, the price will fall.
Now if you want to know the price of 3-bromo-2-cyanopyridine, you should carefully observe the market conditions. You can consult the merchants of chemical materials, who are often involved in this industry and have much insight into the fluctuation of prices. You can also look at various chemical trading platforms, and the price cloth on it may reflect the current market. And different seasons, prices are also different, hot summer and cold winter, or due to different production conditions, prices rise and fall. Therefore, in order to determine the price, it is necessary to collect extensive information and refer to details in order to obtain the approximate number, rather than suddenly make a conclusion.