3-Boc-7-chloro-3h-imidazo[4,5-b]pyridine

3-Boc-7-chloro-3H-imidazolo [4,5-b] pyridine is an organic compound. It has a wide range of uses, especially in the field of medicinal chemistry.
First, it is often used in drug development. Because of its unique chemical structure, it can interact with specific biological targets. In the development of anti-tumor drugs, researchers have modified and optimized its structure to enable the compound to precisely act on specific proteins or signaling pathways in tumor cells, so as to inhibit tumor cell proliferation and induce apoptosis.
Second, it also has important value in the research of drugs for neurological diseases. It can provide a potential therapeutic solution for the treatment of neurological diseases such as Alzheimer's disease and Parkinson's disease by modulating the function of neurotransmitter receptors or ion channels.
Third, in the field of organic synthesis, it is often regarded as a key intermediate. With its structural properties, it can participate in many organic reactions, such as nucleophilic substitution, coupling reactions, etc., to help build more complex organic molecular structures, laying the foundation for the synthesis of compounds with specific biological activities or material properties.
Fourth, it is also emerging in the field of materials science. After specific modifications, it may endow materials with unique electrical and optical properties, providing the possibility for the development of new functional materials.

The synthesis method of 3-Boc-7-chloro-3H-imidazolo [4,5-b] pyridine is an important topic in the field of organic synthesis. In the past, the selection of starting materials was crucial. It often starts with a pyridine derivative with a specific substituent. Due to the controllable stability and reactivity of the pyridine ring, it lays the foundation for the subsequent construction of the imidazolo-pyridine structure.
One method first reacts a pyridine halide containing a suitable substituent with a nitrogen-containing heterocyclic precursor under the catalysis of a base. The choice of base depends on the reaction rate and selectivity, such as potassium carbonate, potassium tert-butyl alcohol, etc. The nucleophilic substitution reaction of the two preliminarily forms an imidazolopyridine skeleton. At this time, the key check point needs to be protected and modified to meet the structural requirements of the target product.
For the introduction of Boc protective group, Boc anhydride is often used as a reagent in a suitable organic solvent, such as dichloromethane, and reacts under the catalyst of an organic base such as triethylamine. This step is designed to protect specific nitrogen atoms and avoid overreaction in subsequent reactions. At the same time, the reaction conditions are optimized, such as temperature control at low temperature, usually 0-5 ° C, to improve the reaction selectivity.
The introduction of 7-chlorine atoms can be used to select suitable chlorination reagents, such as N-chlorosuccinimide (NCS), at a specific stage in the construction of the skeleton. Chlorination reaction is carried out under the action of light or initiator. Precise control of reaction conditions, such as reaction time and reactant ratio, can ensure that chlorine atoms are precisely replaced at the target position.
Another method is to use metal catalytic coupling reaction as the core strategy. Such as palladium-catalyzed cross-coupling reaction, the halide containing the pyridine fragment is reacted with another nitrogen-containing heterocyclic borate or boric acid derivative under the catalysis of palladium catalyst, such as tetra (triphenylphosphine) palladium (Pd (PPh)), in basic conditions and specific solvent systems, such as dioxane-water mixed solvents. By optimizing the amount of catalyst, the type and amount of base, the structure of imidazopyridine can be efficiently constructed. Subsequent to the introduction of Boc protecting group and chlorine atom according to the above method, through multi-step reaction and fine regulation, the final product is 3-Boc-7-chloro-3H-imidazolo [4,5-b] pyridine.

Today, I want to say the market price of 3-Boc-7-chloro-3H-imidazolo [4,5-b] pyridine, but this price often varies with time, place, quantity and quality, and it is difficult to determine the number.
Looking at the market in the past, its price fluctuations can be traced. If the quantity is small and urgent, the price will be high; if the mass production is abundant and the demand is small, the price will be more affordable.
In the past, in a prosperous commercial port, the purchase of this compound in small quantities could reach a high price. Because of the difficult preparation and complicated process, many rare raw materials and exquisite techniques are required, so the cost is high and the price is not cheap.
There are other places. Due to the advanced craftsmanship, the availability of raw materials is easy, and the mass production is quite abundant, the price is slightly reduced. And the trend of market competition also affects its price. Everyone competes to sell, and the price becomes cheaper; exclusive franchise, the price is always on the top.
There are points of quality. Those with high purity are more expensive, and those with a little complexity are less expensive. And changes in the current situation, the production of raw materials, and the regulations of government orders are all related to the price. To know the exact market price, you must carefully observe the current market situation and consult experts, or you can get a glimpse.

3-Boc-7-chloro-3H-imidazolo [4,5-b] pyridine is an organic compound with unique physicochemical properties. Its appearance is often white to off-white solid powder, which is easy to identify and handle in many experiments and production operations.
On solubility, the compound exhibits good solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). Dichloromethane, as a commonly used organic solvent, has a certain similarity in its molecular structure to 3-Boc-7-chloro-3H-imidazolo [4,5-b] pyridine. According to the principle of "similar miscibility", the two easily interact to dissolve the compound. DMF can also effectively dissolve it due to its strong polarity and the formation of hydrogen bonds with the compound. However, in water, its solubility is poor, which is due to the large difference between the polarity of water and the structure of the compound, making it difficult to overcome the intermolecular forces of the compound to achieve dissolution.
The melting point of this compound is relatively high and is in a certain temperature range (the specific value varies depending on factors such as purity). Melting point is an important physical property and can be used to identify purity. The melting point range of high-purity compounds is narrow and close to the theoretical value; if it contains impurities, the melting point will decrease and the melting range will become wider.
From the chemical properties, the Boc (tert-butoxycarbonyl) group in its molecule has certain stability, but under specific conditions, in case of strong acid or high temperature, a deprotection reaction can occur to generate 7-chloro-3H-imidazolo [4,5-b] pyridine. This reaction lays the foundation for further modifying the structure of the compound and introducing other functional groups. The chlorine atom is an active check point in the molecule and can participate in the nucleophilic substitution reaction. Nucleophilic agents can attack the carbon atoms connected to chlorine, causing chlorine atoms to be replaced, thus forming new chemical bonds and expanding the chemical diversity of compounds, which has important application value in the field of organic synthesis.

3-Boc-7-Chloro-3H-imidazolo [4,5-b] pyridine, an organic compound. Quality Standards are concerned with purity, impurities, appearance, melting point, moisture and other key elements.
Purity is the core indicator for measuring the quality of the compound. The higher the purity, the less impurities the target compound contains. Generally speaking, high-purity 3-Boc-7-chloro-3H-imidazolo [4,5-b] pyridine needs to be more than 98% pure, or even higher. Such high purity can meet the stringent requirements of high-end chemical synthesis, drug development and other fields.
In terms of impurities, the type and content of specific impurities need to be carefully checked. Like the impurities of related substances, the content must be strictly controlled at a very low level. The presence of impurities may interfere with subsequent chemical reactions, or affect the stability and biological activity of the product. For example, if the impurities contain potentially toxic substances, it will pose a serious threat to the safety of drugs in drug synthesis applications.
Appearance is also an important manifestation of Quality Standards. The normal appearance of 3-Boc-7-chloro-3H-imidazolo [4,5-b] pyridine should be white to off-white crystalline powder. If the appearance shows abnormal color, foreign matter is mixed, etc., it indicates that the quality of the product is questionable.
Melting point is of great significance for identifying the purity and structural stability of the compound. Its melting point range needs to be relatively fixed. Generally speaking, the melting point of the compound may be in a specific temperature range, such as 150-155 ° C. If the measured melting point deviates from this normal range, it may mean that the purity of the compound is not good, or the crystal form has changed.
Moisture content should also not be ignored. Excessive moisture may cause adverse reactions such as hydrolysis of compounds, affecting their quality and stability. Usually the moisture content is required to be controlled within a certain limit, such as less than 0.5%.
In summary, in order to ensure the high quality of 3-Boc-7-chloro-3H-imidazolo [4,5-b] pyridine, it is necessary to strictly control the above Quality Standards. Negligence in any link may cause the product quality to fail to meet expectations.