3-(Benzyloxy)-5-bromopyridine ,97%

3 - (benzyloxy) -5 -bromopyridine, 97%. The common application scenarios of this compound are as follows.
In the field of pharmaceutical synthesis, it can be a key intermediate. The structure of Geinpyridine is very important in many drug molecules. Benzyloxy and bromine atoms can be converted through a series of chemical reactions to build structures with specific biological activities. For example, by nucleophilic substitution reaction, bromine atoms can be replaced to access specific functional groups, which may endow the final product with unique pharmacological activity and help develop new drugs to treat diseases such as inflammation and tumors.
In materials science, it also has application potential. It may participate in polymerization reactions to build functional polymer materials. Due to the benzoxy group and bromine atom in its structure, the polymer can have unique electrical, optical or mechanical properties. For example, by carefully designing the polymerization reaction, the compound may be introduced into the conjugated polymer backbone to endow the material with good photoelectric properties, which is expected to be used in organic Light Emitting Diodes, solar cells and other optoelectronic devices.
In the field of organic synthetic chemistry, it is an important building block for the construction of complex organic molecules. Chemists can use its reactivity of benzoxy and bromine atoms to form carbon-carbon bonds and carbon-heteroatomic bonds through halogenation reactions, coupling reactions, etc., and then build complex and diverse organic compounds, providing rich structural units and reaction paths for the development of organic synthetic chemistry.

To prepare 3 - (benzyloxy) -5 - bromopyridine, there are three methods.
First, 5 - bromopyridine - 3 - alcohol is used as the starting material. This alcohol can react with benzyl halides, such as benzyl bromide or benzyl chloride, in the presence of bases. For bases, potassium carbonate, sodium carbonate and the like are commonly used. The reaction is carried out in suitable solvents, such as N, N - dimethylformamide (DMF) and acetone. The temperature is moderate, about 50 - 80 ° C, and the target product can be obtained after separation and purification. In this way, the raw materials are easy to obtain, and the reaction conditions are relatively simple. However, the activity or side reaction of benzyl halide needs to be carefully controlled.
Second, 3-bromo-5-hydroxypyridine is used as the starting material. First, its hydroxyl group is protected. The commonly used method is to react with tert-butyl dimethyl silyl chloride (TBSCl) and imidazole in dichloromethane to obtain the product of hydroxyl protection. Then, the product is nucleophilic substituted with benzyl halide under alkali catalysis, such as sodium hydride, in anhydrous tetrahydrofuran. Finally, the silicon group protection is removed with tetrabutylammonium fluoride, and 3- (benzyloxy) -5-bromopyridine can be obtained. Although this step is slightly complicated, the protective group strategy can increase the selectivity of the reaction and reduce the side reactions, resulting in a good yield.
Third, the coupling reaction catalyzed by palladium. Using 3-bromopyridine as the base, with benzyl alcohol as the raw material. In the presence of palladium catalysts such as tetra (triphenylphosphine) palladium (0), ligands such as tri-tert-butylphosphine, bases such as cesium carbonate, in a suitable solvent such as toluene, heated to 100-120 ° C. This reaction can directly form a carbon-oxygen bond to obtain the target product. The palladium-catalyzed reaction has the advantages of high efficiency and high selectivity, but the catalyst cost is high, the reaction conditions are harsh, and the reaction equipment and operation requirements are also high.
All methods have their own advantages and disadvantages. To synthesize this compound, it should be selected according to factors such as raw material availability, cost, and equipment conditions.

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3 - (benzyloxy) - 5 - bromopyridine, content 97%, this compound in storage and transportation, there are a number of precautions need to be paid attention to.
First, because of its chemical properties, it is necessary to avoid contact with strong oxidants, strong acids, strong bases and other substances. Strong oxidants are easy to cause oxidation reactions and cause compound deterioration; strong acids and strong bases interact with it, or change the structure of the compound, damaging its quality, so it should be isolated and stored to prevent accidental chemical reactions.
Second, the control of temperature and humidity is crucial. It should be stored in a cool, dry place, away from direct sunlight and high temperature environment. High temperature can promote the decomposition of compounds or cause other chemical reactions; high humidity may cause it to absorb moisture, affecting purity and stability. Usually, the storage temperature should be 5-30 ° C, and the relative humidity should be controlled at 40% -60%.
Furthermore, the packaging must be tight. Choose suitable packaging materials, such as glass bottles, plastic bottles or iron drums lined with plastic bags, etc., to ensure that the seal is good and prevent leakage from contact with outside air and moisture. During transportation, the packaging should also be prevented from being damaged, and it should be transported stably to avoid package cracking caused by bumps and vibrations.
In addition, it should be handled with care when handling. Because it is a fine chemical, excessive force or collision, or packaging damage, and prevent personnel from exposure to compounds due to rough operation, harming health.
At the end, storage and transportation places must be equipped with corresponding emergency treatment equipment and protective equipment, such as fire extinguishers, adsorbents, gas masks, etc. If there is an accident such as leakage, it can be dealt with in time to minimize the harm.

3- (benzyloxy) -5-bromopyridine, with a purity of 97%, this purity is crucial to its performance. Purity is like the purity of an utensil, which is related to its quality.
High purity can make its chemical properties more stable, with less side reactions during the reaction, just like a well-made device running smoothly, and less impurities and less interference. In organic synthesis reactions, high purity can improve the accuracy of the reaction, the product is purer, and the yield may also increase. Like a skilled craftsman, the material is pure and the finished product is naturally fine.
However, if the purity is not 100%, the 3% impurities may affect its performance. Impurities may react with the main substance, changing the reaction path, making it difficult to achieve the desired reaction effect. And impurities exist or affect its physical properties, such as melting point, boiling point, etc., so that its phase state change under specific conditions does not match expectations.
In practical applications, such as the pharmaceutical field, this purity may affect the quality of drug synthesis, impurities may affect pharmacological activity, and even introduce unknown risks. In materials science, impurities may change the electrical, optical and other properties of materials, making the material unable to meet specific requirements.
Therefore, when using 3- (benzyloxy) -5-bromopyridine, its purity needs to be carefully considered, and according to the specific application and requirements, or further purification, or weighing the influence of impurities, to ensure that its performance meets the needs, in order to make the best use of it and achieve the expected effect.