3-Benzyloxy-1-Boc-amino-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid methyl ester

This is the chemical structure analysis of 3-benzyloxy-1-tert-butoxycarbonyl amino-4-oxo-1,4-dihydropyridine-2-carboxylic acid methyl ester. In its structure, the pyridine ring is the core structure. In the first position of the pyridine ring, there is a tert-butoxycarbonyl amino group, which is obtained by the protection of the amino group by the tert-butoxycarbonyl group. The tert-butoxycarbonyl group can be removed under specific conditions to reveal the active amino group. In the second position of the pyridine ring, there is a carboxylic acid methyl ester group, which is often used as a reaction check point in organic synthesis and can be converted into other functional groups by reactions such as hydrolysis and alcoholysis. The third position of the pyridine ring is connected to the benzyloxy group, and the benzyl group can be left under appropriate conditions. The presence of the benzyloxy group also affects the electron cloud distribution and spatial structure of the molecule. The fourth position of the pyridine ring is the oxo group, that is, the carbonyl group. The existence of this carbonyl group endows the molecule with certain reactivity and can participate in reactions such as nucleophilic addition. Overall, the functional groups of this compound interact with each other, giving it unique chemical properties and reactivity, which may have important application value in the fields of organic synthesis and medicinal chemistry.

3-Benzyloxy-1-tert-butoxycarbonylamino-4-oxo-1,4-dihydropyridine-2-carboxylic acid methyl ester, this compound has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate for the synthesis of drug molecules with complex structures and specific biological activities. Due to its unique chemical structure, it can be modified by various chemical reactions, laying the foundation for the construction of specific pharmacologically active pharmacopharmaceuticals and playing an important role in the development of new drugs for the treatment of specific diseases.
In the field of organic synthesis, it is a characteristic structural unit and participates in the construction of many complex organic molecules. With its different activity check points, it can react with various reagents to form rich carbon-carbon and carbon-heteroatom bonds, enabling organic chemists to synthesize organic materials and functional molecules with novel structures and properties.
In the exploratory research in the early stage of drug development, researchers used this compound to conduct structure-activity relationship research. By modifying its structure, they gained insight into the impact of structural changes on biological activity, providing key information for the design of highly active and highly selective lead compounds, thereby promoting the development of innovative drugs.

There are currently methods for the synthesis of 3-benzyloxy-1-tert-butoxycarbonylamino-4-oxo-1,4-dihydropyridine-2-carboxylic acid methyl esters, which are described in detail below.
First, suitable starting materials, such as pyridine derivatives with specific substituents, are reacted with benzyl halides under the catalysis of bases, and benzyloxy groups can be introduced. Bases, such as potassium carbonate, sodium carbonate, etc., are reacted in suitable organic solvents, such as N, N-dimethylformamide (DMF), and acetonitrile, to control the temperature for smooth reaction.
Then, tert-butoxycarbonyl (Boc) is introduced into the amino group. The commonly used reagent is di-tert-butyl dicarbonate (Boc -2 O), which reacts in organic solvents such as dichloromethane in the presence of organic bases such as triethylamine, N, N-diisopropylethylamine (DIPEA). In this step, attention should be paid to the control of the reaction conditions, so that Boc can selectively bind to the amino group.
As for the construction of the methyl 4-oxo-1,4-dihydropyridine-2-carboxylate moiety, it can be achieved by specific cyclization reactions. Compounds with carbonyl groups and active double bonds are often subjected to intramolecular cyclization under the catalysis of acids or bases. Acids can be selected from p-toluenesulfonic acid, etc., and bases can be considered as sodium alcohols.
The whole synthesis process requires monitoring of the reaction products at each step by means such as thin-layer chromatography (TLC) and nuclear magnetic resonance (NMR) to determine the progress of the reaction and the purity of the product. After each step of the reaction, it should be purified by extraction, column chromatography, etc., to obtain pure 3-benzyloxy-1-tert-butoxycarbonyl amino-4-oxo-1,4-dihydropyridine-2-carboxylic acid methyl ester. Therefore, following these methods, the desired compound can be obtained.

3-Benzyloxy-1-tert-butoxycarbonylamino-4-oxo-1,4-dihydropyridine-2-carboxylic acid methyl ester, this is an organic compound. Its physical and chemical properties are unique and are closely related to many organic synthesis reactions.
Discussing physical properties, at room temperature, the compound may be solid, due to the existence of various functional groups in its structure, or have a certain melting point. The benzyloxy group, tert-butoxycarbonyl amino group, carbonyl group and ester group in the molecule give it a specific polarity. Because benzyl is a non-polar group, and ester, carbonyl, etc. have a certain polarity, the compound may have different solubility in polar and non-polar solvents. It has a certain solubility in polar solvents such as methanol and ethanol, or due to hydrogen bonding; in non-polar solvents such as n-hexane, the solubility may be limited.
Chemical properties, the tert-butoxycarbonyl amino group in the molecule has the effect of protecting the amino group. Under suitable conditions, it can be selectively removed to allow the amino group to participate in the subsequent reaction. Benzyl group in benzoxy group can be substituted or removed by benzyl group under specific reagents and reaction conditions. The 4-position carbonyl group is electrophilic and can participate in nucleophilic addition reactions, such as reacting with nucleophiles containing active hydrogen, such as alcohols and amines, to generate corresponding addition products. The 2-position carboxylic acid methyl ester group can undergo hydrolysis reaction in case of base to generate corresponding carboxylic salts; when catalyzed by acid, it can also undergo ester exchange reaction. These properties make it a key role in the field of organic synthesis in the construction of complex pyridine compounds, providing an important basis for the synthesis of organic molecules with specific structures and functions.

I don't know the price of "3 - Benzyloxy - 1 - Boc - amino - 4 - oxo - 1,4 - dihydro - pyridine - 2 - carboxylic acid methyl ester" in the market. The price of this compound may not be determined due to the difficulty of preparation, the special materials used, and the different needs.
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