3-Aminopyridine-4-carboxylic acid methyl ester

3-Aminopyridine-4-carboxylic acid methyl ester is a kind of organic compound. Its physical properties are quite critical and are of great significance in chemical research and practical application.
In terms of its appearance, it is mostly white to light yellow crystalline powder at room temperature and pressure. This form is easy to observe and process, and is easy to use accurately in many experimental operations and industrial processes.
As for the melting point, it is about 145-148 ° C. The determination of the melting point is an important basis for identifying the compound and judging its purity. The range of melting points is relatively narrow, indicating that its purity is high; if the range of melting points is wider, it may suggest that impurities are mixed in.
In terms of solubility, it is slightly soluble in water. Water is a common solvent, and this solubility characteristic determines its behavior in the aqueous phase system. It has good solubility in organic solvents, such as ethanol, dichloromethane, etc. This characteristic makes it possible to select a suitable organic solvent according to the reaction requirements in order to promote the reaction or to separate and purify the compound.
In addition, the density of 3-aminopyridine-4-carboxylic acid methyl ester is also one of its physical properties. Although the exact density value varies depending on the measurement conditions, it is generally within a specific range. Density data are crucial in processes involving mass and volume conversion, such as formulating solutions and determining the proportion of reactants.
Furthermore, the stability of the compound is also a physical property consideration. Under normal storage conditions, in a dry and cool place, its chemical structure can remain relatively stable. However, care should be taken to avoid contact with strong oxidants, strong acids, strong bases and other substances to prevent chemical reactions from occurring, causing changes in its structure and affecting its original physical and chemical properties.
In summary, the physical properties of 3-aminopyridine-4-carboxylic acid methyl esters are related to each other in terms of appearance, melting point, solubility, density, and stability, which together determine their performance and application in many processes in the field of chemistry.

The synthesis of 3-aminopyridine-4-carboxylic acid methyl ester has attracted much attention in the field of organic synthesis. To make this compound, there are several common paths.
First, pyridine compounds are used as starting materials. Appropriate substituted pyridine can be selected, and carboxyl groups can be introduced at specific positions first. The common method is to carry out electrophilic substitution reaction on the pyridine ring to introduce carboxyl functional groups. Subsequently, the carboxyl group is esterified, and methanol and a suitable catalyst, such as concentrated sulfuric acid or p-toluenesulfonic acid, can be selected to promote the esterification reaction under heating conditions, and then pyridine derivatives containing carboxyl methyl esters can be obtained. After that, the amino group is introduced at the target position of the pyridine ring by suitable amination reagents, such as ammonia gas and reducing agent, or specific amination reagents, so that the 3-amino pyridine-4-carboxylic acid methyl ester is successfully prepared.
Second, it can also be constructed from the perspective of nitrogen-containing heterocyclic ring. The pyridine ring is constructed by multi-step reaction. In the construction process, the reaction steps are cleverly designed, and the carboxyl group and amino group are introduced at the same time, and then the carboxyl group is esterified. For example, some simple nitrogenous and carbon-containing compounds are used as starting materials to construct pyridine rings through cyclization. At the same time, carboxyl groups are formed on the pyridine rings. Then, according to the above esterification method, the carboxyl groups are converted into methyl esters, so as to achieve the synthesis of the target product.
Third, palladium-catalyzed cross-coupling reactions can also be used. Select a suitable halogenated pyridine derivative and carry out a palladium-catalyzed cross-coupling reaction with boric acid or borate esters containing carboxyl methyl esters to first construct the connection between the pyridine ring and the carboxyl methyl ester. Subsequently, through subsequent amination reactions, amino groups are introduced at specific positions of the pyridine ring, and finally 3-aminopyridine-4-carboxylic acid methyl ester is obtained.
These methods have their own advantages and disadvantages. In actual synthesis, it is necessary to carefully choose the appropriate synthesis path according to many factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity and yield requirements of the target product.

3-Aminopyridine-4-carboxylic acid methyl ester is useful in various fields. In the field of medicine, it is a key intermediate for the preparation of new drugs. Due to its unique structure, it can be chemically modified to obtain compounds with specific pharmacological activities, or it can be used as antibacterial and antiviral drugs, or it can play a role in the research and development of anti-cancer drugs. Chemists can adjust the activity and selectivity of molecules by ingenious modification of their amino and ester groups to meet the therapeutic needs of different diseases.
In the field of materials chemistry, 3-aminopyridine-4-carboxylic acid methyl ester has also attracted much attention. It can be used as a basic unit for building functional materials. It can be polymerized or combined with other materials to impart special properties such as optics and electricity. For example, it can participate in the preparation of materials with specific fluorescent properties, emit light and heat in the field of fluorescence sensing, and can detect specific substances acutely. It is used in environmental monitoring, biological detection, etc.
Furthermore, in the field of organic synthesis, this compound is like a cornerstone. With its active checking point, it can participate in various organic reactions to realize the construction of complex organic molecules. Synthetic chemists often use this as a starting material to prepare complex organic compounds with unique properties through carefully designed reaction routes, which contribute to the development of organic synthetic chemistry, help the creation and exploration of new substances, and then promote progress in many related fields.

Methyl 3-aminopyridine-4-carboxylate is an important organic synthesis intermediate in the field of fine chemicals. It is widely used in many fields such as medicinal chemistry and materials science, and plays a key role in the synthesis of specific drug molecules and functional materials.
However, its market price is difficult to generalize, because it is affected by many factors. From the perspective of raw materials, the prices of various starting materials required for the synthesis of methyl 3-aminopyridine-4-carboxylate fluctuate significantly. If the supply of raw materials tightens or the production cost rises, the price of methyl 3-aminopyridine-4-carboxylate will rise. For example, if the supply of pyridine-based starting materials decreases due to production cuts by manufacturers, the price will rise, which will then affect the price of finished products.
Furthermore, the production process also has a significant impact. Advanced and efficient production processes can reduce production costs, improve product quality and output, and thus gain an advantage in market pricing. However, if the production process is complex, energy consumption is high, and the yield is low, the production cost will increase, and the price will also increase.
The market supply and demand relationship is the key to determining the price. When the pharmaceutical industry has strong demand for drugs containing this intermediate, and the production supply cannot be matched in time, the price will rise in response. On the contrary, if the market demand is low and the inventory of manufacturers is overstocked, the price may be lowered in order to reduce the inventory.
In terms of the current market situation, the price may vary significantly due to different quality, purity and packaging specifications. Ordinary industrial grade, with a purity of about 95%, the price per kilogram may be in the hundreds of yuan. And high purity, such as products with more than 99% used in pharmaceutical research and development, the price per gram may reach tens of yuan, which is converted to more than 10,000 yuan per kilogram. However, this is only a rough estimate, and the actual price still needs to refer to the current market conditions and the quotations of various suppliers.

3-Aminopyridine-4-carboxylic acid methyl ester, this substance is related to safety and toxicity, and must not be ignored.
In terms of its safety, it can be stored under appropriate conditions, in a sealed, cool and dry place, and can be stable. However, if exposed to high temperature, open flame or strong oxidizing agent, it will be dangerous. Because it encounters hot topics, or causes decomposition, releasing harmful gases such as nitrogen oxides. If it comes into contact with strong oxidizing agents, or causes violent reactions, or even explosions, extra caution is required.
As for toxicity, many studies have shown that it may be harmful to organisms. For the skin, direct contact, or cause irritation, showing redness, swelling and itching. In the eyes, it can cause eye discomfort and even damage vision. If accidentally inhaled, harmful gases enter the body through the respiratory tract, or affect the respiratory system, causing coughing, asthma and other diseases. After ingesting, or causing damage to the digestive system, there is a risk of nausea, vomiting, and abdominal pain.
In a laboratory or industrial production environment, people who handle this substance must take comprehensive protective measures. Wear protective clothing, gloves, goggles and gas masks to prevent contact and inhalation. And the operation should be carried out in a well-ventilated place or in a fume hood to disperse possible harmful gases. Once a leak occurs, it is necessary to quickly evacuate irrelevant personnel and deal with it strictly according to the emergency procedures to avoid the spread of pollution. In this way, the safety of personnel and the environment can be guaranteed to the greatest extent.