3-aminomethyl-4-chloropyridine

3-Aminomethyl-4-chloropyridine is widely used in the chemical and pharmaceutical fields. It is a key intermediate in the synthesis of medicine. It can be combined with many reagents through specific chemical reactions to create various bioactive compounds. Some drugs for the treatment of specific diseases are obtained by using it as a starting material through delicate synthesis steps.
In the chemical industry, it may be used as a catalyst ligand. With its unique structure, it can form stable complexes with metal ions, which play an important role in catalytic reactions, promote the progress of specific chemical reactions, and improve the reaction rate and selectivity. This helps to optimize the chemical production process, reduce production costs, and enhance production efficiency.
Furthermore, in the field of materials science, 3-aminomethyl-4-chloropyridine may be involved in the preparation of some functional materials. Due to its active chemical properties, it can be used as a building unit to interact with other compounds, endowing materials with special properties, such as electrical conductivity and optical properties, and opening up new paths for the research and development of new materials. In short, it has important uses in many fields and is an indispensable chemical substance for the development of modern technology and industry.

3-Aminomethyl-4-chloropyridine is one of the organic compounds. Its physical properties have many characteristics and are quite important.
Looking at its appearance, it is mostly white to light yellow solid powder under normal conditions. This form is easy to store and use, and provides convenience in many chemical operations.
The melting point is within a certain range. The melting point is the critical temperature at which a substance changes from solid to liquid. The melting point characteristics of this compound play a decisive role in its state change under heating or a specific temperature environment. In some chemical reactions, it is necessary to precisely control the temperature to reach the vicinity of its melting point in order to make the reaction proceed smoothly or achieve the desired reaction effect.
The boiling point is also a key physical property. The boiling point is the temperature at which a substance changes from liquid to gaseous under a specific pressure. Knowing its boiling point is of great significance in operations such as distillation and separation. By controlling the temperature to the boiling point, it can be effectively separated from the mixture for the purpose of purification.
Solubility cannot be ignored either. This compound exhibits a certain solubility in common organic solvents such as ethanol and acetone. The choice of solvent is crucial in chemical reactions, solution preparation, etc. It can be soluble in specific solvents, so that it can be uniformly dispersed in the system, which is conducive to the full occurrence of reactions. It is also convenient to prepare solutions of different concentrations to meet the needs of various experimental or industrial production.
Furthermore, its density also has a specific value. The density reflects the quality of the substance per unit volume. When it comes to metering, mixing and other operations, its density factor needs to be considered. Accurately knowing the density can accurately control the dosage to ensure that the reaction ratio is appropriate and the product quality is stable.
In addition, although the smell of the compound is not strong and pungent, it also has its own unique smell. This odor characteristic can provide certain warnings to the operator during operation, reminding them to take protective measures to ensure the safety of the operating environment.
In summary, the many physical properties of 3-aminomethyl-4-chloropyridine play an indispensable role in chemical research, industrial production and other fields, providing an important basis for its rational application.

To prepare 3-aminomethyl-4-chloropyridine, the following number method is often followed.
First, starting with 4-chloropyridine, it is first oxidized by N-to increase its electrophilicity. Then it is Mannich reacted with formaldehyde and secondary amines to obtain the corresponding Mannich base. Finally, the amino protecting group is removed by reduction to obtain the target. This step is clear, but the N-oxidation and subsequent reaction conditions need to be fine-tuned to improve the yield and purity.
Second, starting from 4-chloropyridine-3-formic acid, the carboxyl group is first converted into an acyl chloride, and then reacted with ammonia to form an amide. The amide is rearranged by Hofmann to obtain 3-amino-4-chloropyridine. Subsequently, the amino group is properly protected, interacted with formaldehyde and halogenating agents to introduce chloromethyl, and finally deprotected to obtain 3-aminomethyl-4-chloropyridine. The rearrangement reaction in this path is critical, and the conditions are strict, and precise temperature control and material ratio are required.
Third, with suitable pyridine derivatives as raw materials, chlorine atoms are introduced at the 4 position after halogenation, and then the aminomethyl is gradually constructed through multi-step reactions, such as nucleophilic substitution, reduction, etc. This process requires clever setting of reaction sequence and conditions according to the characteristics of the raw materials to avoid side reactions and achieve efficient synthesis.
All synthesis methods have advantages and disadvantages. In actual operation, it is necessary to comprehensively consider the availability of raw materials, the ease of reaction conditions, the yield and purity, etc., and choose the most suitable method.

I look at the prices in the market, which often change with time and place, and there are many categories, so it is difficult to generalize. It is difficult for me to determine the market price range of 3-aminomethyl-4-chloropyridine you are inquiring about today.
If you want to know the details, you should visit all the cities. For example, in the city of chemical raw materials, find the trade name and ask its price, or you can get it. And the price is also subject to many factors, such as the abundance of raw materials, the difficulty of production, and the amount of use.
If the raw materials are sufficient, the production method is simple, and there are not many users, the price is low; if the raw materials are scarce, the production is complicated, and everyone is competing for it, the price is high. < Br >
Or you can look at the trading price on the platform of various merchants for reference. Or ask the industry, they have been involved in this trip for a long time, are familiar with the market, or can tell you a more accurate price. However, this information often varies from time to time, and it is necessary to inquire in real time to get the nearest price. Although I cannot specify the range of its price, I may solve your doubts in this way.

3-Aminomethyl-4-chloropyridine is a commonly used raw material for organic synthesis. During its use, several matters must be paid attention to.
Bear the brunt of it, and safety is the top priority. This compound is toxic and irritating to a certain extent, and can cause physical damage if it touches the skin, inhaled or ingested by mistake. When operating, you must wear protective clothing, protective gloves and goggles to ensure that you work in a well-ventilated place to prevent gas inhalation. In case of accidental contact, rinse with plenty of water quickly and seek medical treatment.
Furthermore, storage is also exquisite. Store in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its active chemical properties, certain substances may react violently, so it must be stored separately from oxidants, acids, etc., and must not be mixed to prevent accidents.
Repeat, the control of chemical reaction conditions is related to success or failure. Different reactions have different requirements for temperature, pH, reaction time and other conditions. If you participate in nucleophilic substitution reactions, precise regulation of temperature and pH is crucial. A slight deviation may cause the reaction rate to slow down, or even generate by-products, which affect the purity and yield of the product.
In addition, its solubility should not be underestimated. The solubility in organic solvents is different, and the selection of suitable solvents is of great significance for the reaction process and product separation. If some organic solvents can improve their reactivity, but it is not conducive to the subsequent purification of the product, various factors should be considered when selecting a solvent.
All of these, when using 3-aminomethyl-4-chloropyridine, careful attention should be paid to safety, storage, reaction conditions and solubility, and careful operation can achieve the intended purpose and avoid accidents.