3-amino-6-chloropyridine-2-carboxamide

3-Amino-6-chloropyridine-2-carboxamide (3-amino-6-chloropyridine-2-formamide) is widely used in medicine, chemical industry and other fields.
In the field of medicine, this compound is often the key intermediate for the creation of new drugs. Its unique structure contains amino groups, chlorine atoms and formamide groups, giving it a variety of biological activities. Researchers use this structural modification and modification to develop drugs with specific pharmacological activities. For example, for specific disease-related targets, a series of derivatives are designed and synthesized. After screening and activity evaluation, it is expected to obtain innovative drugs with good curative effect and small side effects, or be used for anti-cancer, anti-infection, neurological disease treatment, etc.
In the chemical field, it also has important functions. Due to its active chemical properties, it can participate in many organic synthesis reactions, and is an important building block for the construction of complex organic compounds. It can be reacted with different reagents to introduce various functional groups to synthesize materials or fine chemicals with special properties. For example, it can be used to prepare functional polymer materials, improve the physical and chemical properties of materials, make them more soluble, stable or conductive, etc., to meet different industrial needs.
Furthermore, in the research and development of agricultural chemicals, it may also play an important role. It can be used as a lead compound to develop pesticides with high insecticidal, bactericidal or herbicidal activities through structural optimization, which can help sustainable agricultural development, improve crop yield and quality, and reduce negative impact on the environment.
From this point of view, 3-amino-6-chloropyridine-2-carboxamide has broad application prospects in many fields due to its unique structure and diverse reactivity. It is an important compound to promote the development of related fields.

3-Amino-6-chloropyridine-2-formamide, this is an organic compound with unique physical properties. Its properties are mostly white to pale yellow crystalline powder at room temperature, with fine and uniform texture.
Looking at its melting point, it is about 200-210 ° C. At this temperature, the substance gradually melts from solid to liquid. This property is of great significance for the identification and purity determination of compounds. Because of its clear melting point and narrow range, it can be characterized by excellent purity.
The solubility of this compound is unique. It is slightly soluble in water and has limited solubility in water. However, it has good solubility in some organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethyl formamide (DMF), etc. This difference in solubility is due to its molecular structure, which contains amino groups, chlorine atoms and formamide groups. These groups have different forces with different solvent molecules, resulting in different solubility.
Its stability is also an important physical property. Under normal storage conditions, if there is no extreme environment such as high temperature, strong light and strong acid and alkali, the properties are relatively stable. However, in the case of strong oxidizing agents or reducing agents, amino groups and chlorine atoms in the structure may chemically react with formamide groups, causing them to decompose or convert into other substances.
In addition, 3-amino-6-chloropyridine-2-formamide may have certain hygroscopicity. In humid environments or absorb moisture in the air, it affects its physical form and purity. When storing, it is necessary to pay attention to moisture.
The above are all common physical properties of this compound. In the fields of chemical synthesis, drug development and materials science, it is essential to have a deep understanding of it, which can help researchers make effective use of its properties and carry out related experiments and applications.

To prepare 3-amino-6-chloropyridine-2-formamide, the following method can be used.
Take 6-chloropyridine-2-formic acid as the starting material. 6-chloropyridine-2-formic acid is co-heated with thionyl chloride. During this process, the carboxyl group of 6-chloropyridine-2-formic acid is converted into an acyl chloride to generate 6-chloropyridine-2-formyl chloride. This reaction needs to be carried out at an appropriate temperature and in an inert gas environment to avoid side reactions.
After 6-chloropyridine-2-formyl chloride is obtained, it is slowly dropped into a reaction vessel containing excess concentrated ammonia water. At this time, the aminolysis reaction of the acid chloride and ammonia occurs, and the chlorine atom of the acid chloride is replaced by the amino group, and then 6-chloropyridine-2-formamide is formed. After the reaction is completed, the extraction product with a suitable solvent such as dichloromethane is dried with anhydrous sodium sulfate, filtered and distilled under reduced pressure to obtain pure 6-chloropyridine-2-formamide.
Then put 6-chloropyridine-2-formamide into a reaction kettle containing an appropriate amount of palladium-carbon catalyst, add a suitable hydrogen supplier, such as ammonium formate or hydrogen (if hydrogen is used, pay attention to safety and control the pressure), and carry out the reduction reaction at an appropriate temperature and pressure. In this reaction, the 6-chloropyridine-2-formamidopyridine ring 6-position chlorine atom is replaced by an amino group to obtain 3-amino-6-chloropyridine-2-formamide. After the reaction, the palladium-carbon catalyst was removed by filtration, and the filtrate was concentrated and recrystallized to obtain the target product 3-amino-6-chloropyridine-2-formamide with high purity.

3-Amino-6-chloropyridine-2-formamide, a fine chemical, is widely used in chemical, pharmaceutical and other fields. However, its market price is difficult to determine exactly, because it is subject to many factors.
First, the cost of raw materials has a great impact. The price of various starting materials required for the preparation of 3-amino-6-chloropyridine-2-formamide fluctuates. If the supply of raw materials is scarce, or the cost rises due to changes in market supply and demand, the situation of origin, etc., the price of 3-amino-6-chloropyridine-2-formamide will rise.
Second, the production process is also the key. Sophisticated and efficient production processes can reduce production costs; on the contrary, if the process is complicated, energy consumption is high and yield is low, the product price will be higher. And different manufacturers have different processes, and prices will also vary.
Third, the market supply and demand relationship determines the price. If the market demand for 3-amino-6-chloropyridine-2-formamide is strong and the supply is limited, the price will rise; if the market demand is weak and the supply is excessive, the price will inevitably fall.
Fourth, product purity and quality are also related to price. High-purity, high-quality products, due to the difficulty of production and high testing requirements, the price is often higher than that of ordinary quality.
Looking at the past market, the price of 3-amino-6-chloropyridine-2-formamide may fluctuate between tens of yuan and hundreds of yuan per kilogram. However, this is only a general range. Today, its price may fluctuate significantly due to changes in the above factors. For accurate prices, it is advisable to consult relevant chemical product suppliers and distributors for details, or refer to the latest quotations from professional chemical product trading platforms.

3-Amino-6-chloropyridine-2-formamide, the Quality Standard of this substance is related to its many characteristics. First of all, the purity is the key standard, and the purity should reach a very high proportion, usually more than 98%. The content of impurities must be strictly controlled, because impurities will affect its reactivity and stability. Its appearance is also required. It should be white to off-white crystalline powder with uniform color and no foreign matter. If there is variegation or agglomeration, it does not meet the standard.
Melting point is also an important indicator, usually in a specific temperature range, such as 180-185 ° C. If the melting point deviation is too large, it indicates that the substance is impure or abnormal crystal form. In addition, the inspection of relevant substances is indispensable. For example, high-performance liquid chromatography is used to accurately determine the content of specific impurities to ensure that they are within the limit, so as to ensure product quality and safety. The moisture content should also be paid attention to. Generally, it should be controlled at a low level, such as less than 0.5%. Too much moisture or cause adverse reactions such as hydrolysis, which affect the quality.
Elemental analysis can determine the content of carbon, hydrogen, nitrogen, chlorine and other elements. The deviation from the theoretical value should be minimal to verify the correctness of the material structure. The characteristic absorption peak of infrared spectrum can verify the specific functional groups in the molecular structure. Compared with the standard map, it must be highly consistent to confirm that the material structure is correct. This is an important Quality Standard of 3-amino-6-chloropyridine-2-formamide, which must be strictly followed in the production and application process to ensure high quality and stable performance of the product.