3-Amino-6-Bromo-2-Methylpyridine

3-Amino-6-bromo-2-methylpyridine is an important compound in the field of organic chemistry. It has a wide range of uses and has significant work in many fields.
First, in the process of drug synthesis, this compound is often used as a key intermediate. Due to its unique structure and specific reactivity, it can be combined with other molecules through a series of chemical reactions to build complex drug molecular structures. Through the rational modification and transformation of its amino group, bromine atom and methyl group, drugs with different pharmacological activities can be created to deal with various diseases.
Second, in the field of materials science, 3-amino-6-bromo-2-methylpyridine also has important uses. It can be used to synthesize functional materials, such as conductive polymers, luminescent materials, etc. Its special chemical structure endows materials with unique electrical and optical properties, providing opportunities for the development and preparation of new materials.
Furthermore, in the study of organic synthetic chemistry, this compound is often used as a model substrate to explore new reaction pathways and synthesis methods. By studying the chemical reactions it participates in, chemists can expand the strategy of organic synthesis, improve synthesis efficiency and selectivity, and promote the development of organic synthetic chemistry.
In summary, 3-amino-6-bromo-2-methylpyridine plays an important role in the fields of drug synthesis, materials science, and organic synthetic chemistry due to its unique chemical structure and reactivity, and is of great significance for promoting the progress of related fields.

The synthesis method of 3-amino-6-bromo-2-methylpyridine has been known for a long time. One method is to use 2-methyl-6-bromo-pyridine as the starting material. This compound can be introduced into the nitro group at a specific position in the pyridine ring through nitration reaction. This nitration step requires careful operation. Select suitable nitrifying reagents, such as mixed acids (a mixture of nitric acid and sulfuric acid), and control the reaction temperature, time and material ratio to prevent excessive nitrification or side reactions. After the nitro compound is obtained, the nitro group is converted into an amino group through reduction reaction. Commonly used reduction methods include catalytic hydrogenation, in which precious metals such as palladium and platinum are supported on suitable supports as catalysts and reacted in a hydrogen stream. This process requires control of reaction pressure, temperature and catalyst dosage. There are also chemical reduction methods, such as iron powder, zinc powder and other metals and acids, to gradually reduce nitro to amino groups.
There is another method, using 2-methylpyridine as the starting material, first brominating, and introducing bromine atoms at the 6-position of the pyridine ring. For this bromination reaction, bromine, N-bromosuccinimide (NBS), etc. can be used as brominating agents, depending on the reaction conditions and needs. After the bromination is completed, the amination reaction is carried out. The method of amination, or the reaction is heated in a specific solvent with ammonia and suitable bases, so that the bromine atom is replaced by an amino group. In this process, the nature of the solvent, the type and dosage of the base, the reaction temperature and time are all key factors, and fine regulation is required to obtain the target product 3-amino-6-bromo-2-methylpyridine.

3-Amino-6-bromo-2-methylpyridine, a fine organic chemical raw material, is widely used in medicine, pesticides, materials and many other fields. To know its market price, it is necessary to understand that its price often varies due to quality, purity, purchase volume, market supply and demand and many other factors.
In the past, in the chemical raw material trading market, if the quality is average and the purity is about 95%, small batch purchases (1-5 kg per batch), the price may be 800-1200 yuan per kilogram. If the purchase volume is slightly larger (5-20 kg per batch), due to the scale effect, the supplier may have a discount, and the price per kilogram may be reduced to 700-1000 yuan.
If the purity requirements are strict, reaching 98% and above, the small batch purchase price may rise to 1500-2000 yuan per kilogram. If the purchase volume exceeds 20 kg, the price per kilogram may be 1300-1800 yuan.
Market supply and demand also have a great impact on the price. If the pharmaceutical industry has a large increase in demand for drugs containing this ingredient, resulting in a shortage of supply, the price will rise; conversely, if the market is oversupplied, the price may fall.
In addition, prices vary in different regions. In places with developed economies and concentrated chemical industries, prices may be slightly lower due to intense competition and convenient logistics; in remote areas, prices may be slightly higher due to factors such as transportation costs.
Therefore, to know the exact market price, it is advisable to consult a number of chemical raw material suppliers, combine their own procurement needs, and comprehensively consider various factors before obtaining a suitable quotation.

3-Amino-6-bromo-2-methylpyridine is one of the organic compounds. Its physical and chemical properties are of great value to explore.
In terms of its physical properties, under normal temperature and pressure, this substance is mostly in a solid state. Looking at its appearance, it is often a white to off-white crystalline powder, which is due to the orderly arrangement of its molecular structure, resulting in a specific aggregated state. Its melting point is also an important physical property, but the exact value often varies depending on factors such as purity. Generally speaking, under specific conditions, there is a relatively stable melting point range, and this temperature limit is the key node for a substance to change from a solid state to a liquid state.
As for its solubility, in organic solvents, such as common ethanol, dichloromethane, etc., it exhibits a certain solubility. This is due to the existence of suitable interaction forces between the compound molecule and the organic solvent molecule, such as van der Waals force, hydrogen bond, etc., so that the molecule can be uniformly dispersed in the solvent system. However, in water, its solubility is relatively limited, because its molecular polarity and water molecule polarity match are not ideal.
In terms of its chemical properties, the presence of amino groups gives this compound significant alkalinity. Nitrogen atoms in amino groups have lone pairs of electrons, which are easy to combine with protons, and can undergo protonation reactions in acidic environments. This property is crucial in many organic synthesis reactions. Bromine atoms are active substituents and can participate in nucleophilic substitution reactions. Due to the large electronegativity of bromine atoms, the C-Br bond has a certain polarity and is vulnerable to nucleophilic attack, so as to achieve the purpose of replacing bromine atoms with other groups. Although methyl is relatively stable, it may also participate in the reaction under specific reaction conditions. For example, under the action of strong oxidants, methyl can be oxidized to other oxygen-containing functional groups.
In addition, the conjugated structure of the pyridine ring endows the compound with a unique electron cloud distribution, which affects its reactivity and selectivity. In various chemical reactions, the pyridine ring can be used as an electron receptor or donor to participate in the electron transfer process, which in turn promotes the reaction. The physicochemical properties of 3-amino-6-bromo-2-methylpyridine are complex and interrelated, and are of great significance in many fields such as organic synthesis and medicinal chemistry.

3-Amino-6-bromo-2-methylpyridine is a chemical substance. When storing and transporting, many key matters need to be paid attention to.
Bear the brunt, and the storage environment must be dry and cool. This chemical substance is highly susceptible to moisture, and moisture may cause it to deteriorate, affecting quality and performance. If placed in a high temperature place, it may cause chemical reactions or even danger. Therefore, it should be stored in a dry and ventilated place with suitable temperature, away from heat sources and water sources.
Secondly, attention should be paid to sealed storage. Because the substance may react with oxygen, carbon dioxide and other components in the air, sealing can effectively isolate the air and avoid such reactions. The storage container should have good sealing, and it should be sealed in time after use to prevent the substance from evaporating or deteriorating.
Furthermore, ensure that the packaging is intact during transportation. The packaging should be able to withstand a certain external impact to prevent the container from breaking due to collision and vibration, and the leakage of chemical substances. At the same time, it is necessary to use suitable transportation methods in accordance with relevant regulations, and abide by transportation safety guidelines.
In addition, whether it is storage or transportation, it must be strictly separated from oxidants, acids, alkalis and other substances. Because of its active chemical properties, contact with these substances or cause violent reactions, endangering safety.
Finally, the storage and transportation sites should be managed by professionals, and prominent warning signs should be posted to remind personnel to pay attention to safety. Managers need to be familiar with the characteristics of the chemical substance and emergency treatment methods, and can respond quickly and correctly in the event of an accident. In this way, the safety and stability of 3-amino-6-bromo-2-methylpyridine during storage and transportation can be ensured.