3-amino-5-nitropyridine

3-Amino-5-nitropyridine is 3-amino-5-nitropyridine, which has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate for the synthesis of many bioactive compounds. For example, in the synthesis of some drugs with antibacterial, anti-inflammatory or anti-tumor effects, 3-amino-5-nitropyridine plays an indispensable role. Through specific chemical reactions, its structure can be ingeniously integrated into the target drug molecule, giving the drug unique pharmacological properties.
In the field of materials science, it also has important applications. It can be used to prepare functional materials, such as some materials with special optical or electrical properties. Through chemical modification and polymerization, the prepared materials can exhibit unique optoelectronic properties and have potential application value in optoelectronic devices such as organic Light Emitting Diode (OLED) and solar cells.
In addition, in organic synthetic chemistry, 3-amino-5-nitropyridine, as a multifunctional reagent, can participate in the construction of many complex organic molecules. Due to the presence of amino and nitro groups in the molecular structure, various chemical reactions such as nucleophilic substitution and reduction can occur, providing organic synthetic chemists with rich strategies to create organic compounds with novel structures and unique properties, thereby promoting the continuous development and innovation of organic synthetic chemistry.

3-Amino-5-nitropyridine is an important intermediate in organic synthesis. There are several common methods for its synthesis.
First, pyridine is used as the starting material. First, pyridine is nitrified to introduce the nitro group into the pyridine ring. Due to the electron cloud distribution of the pyridine ring, specific reaction conditions and reagents are required during nitrification to selectively introduce the nitro group into the 3rd or 5th position. Then, the resulting nitropyridine is aminated. In this amination step, many reagents, such as ammonia and corresponding catalysts, can be used to introduce amino groups at specific positions to obtain 3-amino-5-nitropyridine.
Second, nitrogen-containing heterocyclic compounds can also be used as starters, through a series of functional group conversion reactions. For example, first modify the existing functional groups on the heterocyclic ring, such as halogenation, substitution, etc., to construct a suitable reaction check point. Then nitro and amino groups are introduced in sequence to synthesize the target product through multi-step reactions. In this process, the control of the conditions of each step of the reaction is extremely critical, such as the choice of temperature, solvent, and catalyst, which all affect the yield and selectivity of the reaction.
Third, the coupling reaction catalyzed by transition metals. Select suitable halogenated pyridine derivatives, and couple with nitro and amino-containing reagents under the action of transition metal catalysts. This method can precisely introduce the required groups at specific positions in the pyridine ring, and the reaction conditions are relatively mild, and the yield is also considerable. However, the cost and recycling of transition metal catalysts also need to be considered in practical synthesis.
In short, the synthesis of 3-amino-5-nitropyridine has advantages and disadvantages. In practical application, it should be selected according to the availability of raw materials, cost, yield and selectivity.

3-Amino-5-nitropyridine is one of the organic compounds. Its physical properties are unique. In terms of color state, it is mostly light yellow to yellow crystalline powder at room temperature, which is delicate in appearance. The color and shape can be intuitively identified by the naked eye.
When it comes to the melting point, it is between 157-160 ° C. When the ambient temperature gradually rises, its solid structure begins to change, the orderly arrangement of the lattice is broken, and the molecules are energized and flexible. The melting point characteristic is the key basis for the identification and purification process.
Solubility is also an important physical property. In water, its solubility is very small, and the polarity of water and the structure of the compound make it difficult for the two to blend. However, organic solvents are different, such as methanol, ethanol, dichloromethane, etc., which have good solubility. This is because the polarity and intermolecular forces of organic solvents are more suitable for the compound, and the intermolecular interactions make the two mutually soluble. This solubility is of great guiding significance in the operation of organic synthesis, such as the selection of reaction media and the separation of products.
Furthermore, its density is also fixed. Although the exact value varies slightly due to the measurement conditions, it is roughly within a specific range. This density characteristic is related to the measurement and mixing of materials, and is related to the accuracy of the reaction.
In addition, the chemical properties of this compound are relatively stable at room temperature and pressure. However, when exposed to high temperatures, open flames, or strong oxidants, it may cause a violent reaction. This physical and chemical properties are interrelated. When storing and using, it is necessary to exercise caution to ensure safety.

3-Amino-5-nitropyridine is an organic compound with the following chemical properties:
1. ** Basic **: Its pyridine ring nitrogen atom has an unshared electron pair, which is alkaline and can react with acids to form salts. In the case of hydrochloric acid, nitrogen atoms will combine with hydrogen ions to form corresponding pyridine salts. This property can be used for separation and purification in organic synthesis. Due to the increase in the polarity of the compound after salt formation, the solubility in water becomes greater, and it is easier to separate from other insoluble impurities in water.
2. ** Nucleophilic Substitution Reaction **: Amino (-NH ²) is a donor electron group, which can increase the electron cloud density of the pyridine ring, especially the electron cloud density of the amino o-o and para-position, which is more susceptible to attack by nucleophilic reagents. When suitable nucleophilic reagents exist, under certain conditions, nucleophilic substitution reactions can occur on the pyridine ring, such as with halogenated hydrocarbons. Halogen atoms are replaced by nucleophilic reagents to form new bonds such as carbon-nitrogen or carbon-oxygen, which are used to construct more complex organic molecular structures.
3. ** Redox Reaction **: Nitro (-NO ²) is oxidizing and can be reduced under the action of suitable reducing agents. For example, in the system of metals (such as iron, zinc) and acids (such as hydrochloric acid), the nitro group can be gradually reduced to an amino group, that is, 3-amino-5-nitropyridine is converted to 3,5-diaminopyridine, which is an important reaction step in the preparation of polyaminopyridine-containing compounds. At the same time, the pyridine ring can also be oxidized by some strong oxidants, but the reaction conditions and products vary depending on the type of oxidant.
4. ** Substituent Reaction **: Amino groups can undergo many reactions, such as acylation reactions, which react with acyl chloride or acid anhydride under alkali catalysis, and amino hydrogens are replaced by acyl groups to form amide derivatives. Such reactions can be used to protect amino groups or introduce specific functional groups to change the properties of compounds. Nitro can also participate in some special reactions, such as nucleophilic substitution reactions on aromatic rings with nucleophiles under certain conditions, or participate in complex reactions such as rearrangement as a leaving group, providing a way for the synthesis of special structure pyridine derivatives.

The price of 3-amino-5-nitropyridine in the market is difficult to determine. This changes due to many reasons, one of which is the situation of supply and demand. If there are many people who want it, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price may fall. Second, the price of raw materials also has an impact. To make this product requires all kinds of raw materials. If the price of raw materials rises, the cost increases, and the price in the market will also rise; if the price of raw materials falls, the price may decline. Third, the different production methods and processes also lead to different costs, which affects the selling price.
In addition, the manufacturers vary, and their pricing is also different. A famous factory, with its trustworthiness and high quality, may have a slightly higher price; while a new factory is competing for the market, or reducing its price. And the market is different in different regions, and the price is also different. In prosperous places, its logistics and operation costs are high, and the price may be higher than that of remote soil.
With common sense, its price per gram may be between a few yuan and tens of yuan. However, this is only a rough estimate. If you want to know the exact price, you can consult the chemical raw material supplier in detail, or check it carefully on the chemical product trading platform to get the real-time price in the market.