3-Amino-5-fluoropyridine

3-Amino-5-hydroxypyridine has a wide range of uses. In the field of medicinal chemistry, it can be used as a key pharmaceutical intermediate. The special structure of the geinpyridine ring and the chemical activity of amino and hydroxyl groups can participate in many organic reactions. After ingenious modification and derivatization, a variety of compounds with specific pharmacological activities can be synthesized. For example, in the synthesis of some antibacterial drugs, 3-amino-5-hydroxypyridine can be used as a starting material to construct drug molecules that have inhibitory or killing effects on specific bacteria through a series of reactions.
It also has important functions in the field of materials science. Due to its heteroatoms such as nitrogen and oxygen, it can participate in the molecular design and construction of materials. It can be used to prepare organic materials with special electrical and optical properties. For example, by complexing with specific organic ligands, fluorescent materials can be prepared, which can be used in optoelectronic devices such as Light Emitting Diode, giving the material unique luminescent properties.
In agricultural chemistry, 3-amino-5-hydroxypyridine can be used as a pesticide intermediate. By chemical modification, pesticides with control effect on crop diseases and insect pests can be synthesized. Due to its unique structure, it can be combined with specific targets in pests or pathogens to exert control effects, and may have higher selectivity and lower environmental toxicity than traditional pesticides.
In addition, in the field of organic synthetic chemistry, as an important organic synthetic building block, it can participate in various cyclization reactions, coupling reactions, etc., providing an effective way for the synthesis of complex organic compounds, helping organic chemists to construct organic molecules with diverse structures and unique functions, and promoting the development of organic synthetic chemistry.

3-Amino-5-hydroxypyridine, which is an organic compound. Its physical properties are as follows:
Viewed at room temperature, it is mostly in the state of white to light yellow crystalline powder. Under sunlight, its delicate texture can be seen, like fine grains closely interdependent.
Smell it, there is no significant pungent smell, only a slight special smell, not strong irritation, not to cause a strong impact on the sense of smell.
Its melting point is in a specific range, roughly between [X] ° C and [X] ° C. This temperature range allows the substance to undergo a physical state transformation under a certain degree of heat, gradually melting from solid to liquid. This melting point characteristic is of great significance in the separation, purification and control of related chemical reaction processes of substances.
In terms of solubility, it has a certain solubility in water and can partially dissolve to form a uniform dispersion system. However, it has better solubility in organic solvents such as ethanol and acetone, and can quickly and fully fuse with these organic solvents to form a uniform solution. This solubility characteristic makes it possible to reasonably select suitable solvents according to actual needs in many operations such as chemical synthesis, separation and extraction, so as to achieve effective treatment and application of the substance.
In addition, 3-amino-5-hydroxypyridine also has a specific density, which is approximately [X] g/cm ³. This density data is an indispensable basic parameter for the quantitative analysis, material calculation, and distribution of the substance in different media.

3-Amino-5-hydroxypyridine is an organic compound. It is weakly basic and acidic. It can participate in a variety of chemical reactions and exhibit unique chemical properties.
Its basicity is derived from the amino group. The nitrogen atom in the amino group has an unshared electron pair, which can bind protons and appear alkaline in acidic solutions. In case of strong acid, the amino nitrogen atom will accept protons and form positively charged ions.
Acidic is due to the hydroxyl group. The oxygen atom in the hydroxyl group has high electronegativity and the polarity of the hydrogen-oxygen bond is large. The hydrogen atom is more likely to leave in the form of protons and become acidic in alkaline solutions. When exposed to strong bases, the hydroxyl hydrogen will be captured, forming negatively charged oxygen-negative ions.
3-Amino-5-hydroxypyridine can also undergo electrophilic substitution reaction. Both amino and hydroxyl groups are electron-donating groups, which can increase the electron cloud density of the pyridine ring, especially when the amino and hydroxyl groups are adjacent and para-located, which is more likely to attract the attack of electrophilic reagents and cause substitution.
In addition, it can participate in condensation reactions. Amino and other carbonyl-containing compounds, such as aldose and ketone, can condensate under suitable conditions to form carbon-nitrogen double-bond compounds.
Furthermore, hydroxyl groups can be esterified. Under the action of catalysts with organic acids or their derivatives, hydrogen atoms in hydroxyl groups are replaced by acyl groups to form corresponding ester compounds. 3-Amino-5-hydroxypyridine is widely used in organic synthesis, medicinal chemistry and other fields, and is often used as a key intermediate for the preparation of various functional compounds and drugs.

To prepare 3-amino-5-bromopyridine, a variety of ancient methods can be used.
First, pyridine is used as the starting point, first brominated and then ammoniated. In an appropriate solvent, such as glacial acetic acid, add bromine and catalysts, such as iron powder, pyridine can be brominated to obtain 5-bromopyridine. This step of reaction must be controlled by temperature and time to prevent the generation of polybrominates. After liquid ammonia and 5-bromopyridine, in an autoclave, add an appropriate catalyst, such as copper salt, and the amination reaction can obtain 3-amino-5-bromopyridine. The reaction principle is the electrophilic substitution of bromine and the nucleophilic substitution of ammonia.
Second, 3-aminopyridine is used as the raw material to carry out the method of bromination. Select an appropriate brominating agent, such as N-bromosuccinimide (NBS), add an initiator, such as benzoyl peroxide, in an inert solvent, such as carbon tetrachloride, and initiate the reaction by light or heat, so that 3-aminopyridine is brominated to obtain the target product. This process requires attention to the protection and deprotection of amino groups, because of their high activity and easy to cause side reactions. If unprotected, substitution occurs during bromination or at the amino ortho-position. The amino group can be protected with an appropriate protective group, such as tert-butoxycarbonyl (BOC), and then de-protected after bromination.
Third, the pyridine derivative is used as the starting material and converted in multiple steps. For example, the pyridine derivative containing the appropriate substituent is selected, and the functional group is first converted to obtain the group that can be replaced by the amino group and the bromine atom. For example, the nitro group is first introduced, and then reduced to the amino group. At the same time, the group that can be replaced by bromine is introduced, and the bromine atom is introduced through the halogenation reaction. Through the rational design of the reaction sequence and conditions, the target molecular structure is gradually constructed. In this way, each step of the reaction needs to be carefully planned to ensure the yield and selectivity of each step, so as to achieve the

In today's world, the market is complex, and all kinds of goods are sold, and the prices are different. If you want to know the market price range of 3-amino-5-bromopyridine, please listen to me one by one.
Husband 3-amino-5-bromopyridine has its uses in the field of chemical medicine. The method of preparation, complex or simple, the price of the materials used, and the fineness of the process are all related to its price. And changes in market supply and demand are also the main reasons.
If the supply exceeds the demand, the price will tend to be flat, or there will be a downward state; if the demand exceeds the supply, the price will rise, and it is difficult to have a fixed number. < Br >
Looking at the market conditions, the range of prices varies depending on the quality, source, and quantity. Roughly speaking, those with high quality and large quantities may be priced between tens of gold and hundreds of gold per gram; if the quality is slightly inferior and the quantity is thin, the price may be different, or it may be hundreds of gold per gram.
However, this is only an approximate number. The market price is impermanent and changes with market conditions. When traders trade, they should carefully observe the market conditions and inquire from multiple parties before they can obtain a suitable price.
Because of the chemical products, the price is all, not a word can be determined. The above is for reference only, and the actual price shall be subject to the current market conditions.