3-Amino-5-chloropyridine

3-Amino-5-bromopyridine has a wide range of main uses. In the field of pharmaceutical synthesis, this compound is often used as a key intermediate. Due to its unique structure, it can be used to create complex molecular structures with biological activity through many chemical reactions, and then applied to the creation of new drugs. For example, when developing specific anti-disease drugs, 3-amino-5-bromopyridine can introduce specific functional groups into molecules, optimize the interaction between drugs and targets, and improve drug efficacy and selectivity.
In the field of materials science, 3-amino-5-bromopyridine also shows potential value. It can participate in the preparation of organic materials with special optoelectronic properties. Through rational design and synthesis, 3-amino-5-bromopyridine-based materials may exhibit unique optical absorption and emission characteristics, which may have application opportunities in the field of organic Light Emitting Diode (OLED), solar cells and other devices, helping to improve device performance and efficiency.
Furthermore, in the field of pesticide chemistry, 3-amino-5-bromopyridine is also useful. It can be used as an important raw material for the synthesis of new pesticides. After chemical modification, pesticides are given better biological activity and environmental compatibility, helping to improve the control effect of crop diseases and pests, while reducing the adverse impact on the environment. In conclusion, 3-amino-5-bromopyridine has important uses in many fields such as medicine, materials, and pesticides due to its unique chemical structure, providing key support and opportunities for the development of various fields.

To prepare 3-amino-5-bromopyridine, there are various methods. First, pyridine can be started, brominated first and then ammoniated. Start with pyridine, and under appropriate conditions, react with bromine to replace the bromine atom at the 5th position of the pyridine ring. In this step, a suitable catalyst and reaction environment need to be selected to increase the yield of 5-bromopyridine. After obtaining 5-bromopyridine, let it react with ammonia sources, such as liquid ammonia, under specific conditions, and ammonia replaces bromine to obtain 3-amino-5-bromopyridine. In this process, the temperature, amount of catalyst and reaction time during bromination need to be precisely regulated to avoid side reactions; the amination step also needs to pay attention to the reaction conditions, such as pressure, temperature, etc., so that the reaction is smooth.
Second, pyridine derivatives containing suitable substituents can also be used as raw materials. If there are pyridine derivatives, there are groups that can be substituted by amino and bromo groups at a certain position, and the substitution activity of the groups is suitable. After a specific reaction, an amino group is introduced, and then a bromo group is introduced at another stage. For example, if a pyridine derivative has a leavable group at a certain position, it is first treated with an amination reagent to replace the leavable group with an amino group. Subsequently, under another set of reaction conditions, brominated reagents are used to introduce bromide to the target 5 position to achieve the synthesis of 3-amino-5-bromopyridine. This path requires careful selection of starting materials and reagents in each step to ensure reaction selectivity and yield.
Third, heterocyclic synthesis can also be considered. A number of nitrogen-containing and carbon-containing small molecules are used as starting materials to form pyridine rings through cyclization, and amino and bromide groups are ingeniously introduced during or after cyclization. For example, with suitable nitriles, amines and bromine-containing compounds, under catalyst, heating and other conditions, the ring is gradually reacted, and the amino and bromine groups are precisely positioned based on the 3rd and 5th positions of the pyridine ring. This approach requires a high degree of control of the reaction mechanism and reaction conditions, but if properly controlled, the product may be efficiently obtained.

3-Amino-5-bromopyridine has unique physical and chemical properties and is widely used in various chemical and scientific research fields.
Looking at its physical properties, it is mostly white to light yellow crystalline powder at room temperature, which is easy to use and handle. Its melting point usually falls within a specific range, which is of great significance for the identification and purification of compounds. And it has a certain solubility in specific solvents, such as in organic solvents, it can show good solubility, paving the way for subsequent reactions and applications.
In terms of its chemical properties, in 3-amino-5-bromopyridine, the amino group has the property of electron donator, and the bromine atom has the property of electron-withdrawing. The interaction of the electronic effects of the two makes the chemical activity of the compound unique. Amino groups can participate in many nucleophilic reactions, such as reacting with acid chloride to form corresponding amide compounds; reacting with aldides and ketones to form Schiff bases. Bromine atoms can undergo substitution reactions under suitable conditions, such as the Suzuki reaction, which can couple with organoboronic acids to form carbon-carbon bonds. This reaction is frequently used in the construction of complex organic molecular structures.
In addition, 3-amino-5-bromopyridine can form weak interactions such as hydrogen bonds between its molecules due to its heteroatoms such as nitrogen and bromine, which affects its crystal structure and aggregate state behavior, and then affects its macroscopic physicochemical properties. Such unique properties make 3-amino-5-bromopyridine attract much attention in the fields of medicinal chemistry and materials science, and it is an important intermediate for the synthesis of new drug molecules and functional materials.

In today's world, the price of 3-amino-5-bromopyridine in the market is often changed due to various reasons such as current situation, supply and demand, and craftsmanship, and it is difficult to determine one. However, roughly speaking, its price may range from tens to hundreds of yuan per gram.
The production of this product is complicated, and it requires all kinds of exquisite methods, which requires huge manpower, material resources, and financial resources. This is one of the reasons for the high price. And it is widely used in various fields such as medicine and chemical industry, and the demand is quite strong, which is also one of the reasons for the high price.
If it is in the way of medicine, it is the key to synthesizing wonderful medicines, and it can help doctors make good medicines to cure diseases, and the effect is significant, so although its price is high, it is also important for the industry. In the way of chemical industry, it can be the basis for creating novel materials and has a wide range of uses. As a result, its market price fluctuates within a certain range.
However, the market is impermanent, and the price is uncertain. Either because of the abundance of raw materials, or because of the ease of government orders, or because of the new creation of science and technology, its price may rise or fall. Therefore, if you want to know its exact price, you should consult experts in the industry and merchants in the market, so that you can obtain real-time numbers to meet the needs of all things.

3-Amino-5-bromopyridine is an important intermediate in organic synthesis. Its storage conditions are very critical, which is related to the stability and subsequent use effect of the substance. The relevant requirements are described in detail below:
First, it needs to be placed in a cool and well-ventilated place. This substance is more sensitive to temperature and air circulation. A cool environment can avoid chemical reactions caused by excessive temperature. Good ventilation can disperse volatile gases that may accumulate in time to prevent danger. If the storage environment temperature is too high, it may cause the substance to accelerate decomposition or other uncontrollable reactions, which will affect its quality and purity.
Second, ensure that the storage container is sealed. A sealed container can effectively block the entry of external moisture, oxygen and other substances. 3-Amino-5-bromopyridine easily reacts with oxygen and water in the air, causing deterioration. If it comes into contact with water, it may cause reactions such as hydrolysis and change the structure and properties of the substance.
Third, keep away from fire and heat sources. Because of its certain chemical activity, it may cause serious dangers such as combustion or even explosion in case of open flames and hot topics. In the storage area, smoking and operations that may produce open flames are strictly prohibited, and heat sources should be effectively isolated.
Fourth, the substance needs to be stored separately from oxidants, acids, etc., and must not be mixed. 3-Amino-5-bromopyridine in contact with oxidants is prone to oxidation reactions, and contact with acids may cause acid-base neutralization and other reactions that are not conducive to its storage, which will destroy the chemical structure and purity of the substance.
Fifth, the storage site should be equipped with suitable materials to contain substances that may leak. In case of leakage, it can be treated in a timely and effective manner to avoid pollution to the environment and prevent further safety hazards caused by leaked substances.