3-amino-5-bromopyridine

3-Amino-5-bromopyridine is widely used in the field of organic synthesis. First, it is a key raw material for the preparation of medicine. When creating antibacterial, antiviral and anti-cancer drugs, this compound is often relied on. Due to its unique structure, it can introduce specific functional groups, endow the drug with unique activity, so that the drug can accurately act on the target of pathogens or cancer cells, and achieve the effect of treating diseases.
Second, it also plays an important role in pesticide synthesis. It can be used to construct efficient and low-toxicity pesticides to help agricultural prevention and control of pests and diseases. Such pesticides can precisely act on pests, but have less harm to the environment and beneficial organisms, which is suitable for the green development of modern agriculture.
Furthermore, in the field of materials science, 3-amino-5-bromopyridine is also useful. It can be used as a monomer to participate in the synthesis of polymer materials, imparting special electrical, optical or mechanical properties to the materials. For example, the preparation of polymers with special electrical conductivity may have applications in the manufacture of electronic devices.
In addition, in the field of organometallic chemistry, it can be used as a ligand to form complexes with metal ions. Such complexes often exhibit unique catalytic activity and selectivity in catalytic reactions, enabling the efficient progress of various organic reactions, such as carbon-carbon bond formation reactions, and promoting the development of organic synthesis chemistry.

The synthesis method of 3-amino-5-bromopyridine is very particular. One method is to use 5-bromopyridine-3-carboxylic acid as the starting material. First, the acid is heated with dichlorosulfoxide to transform the acid into an acid chloride. This step needs to be carried out at an appropriate temperature and time to ensure that the reaction is complete. Then, the acid chloride is reacted with ammonia water to obtain 5-bromopyridine-3-formamide. Then the formamide is treated with a system composed of sodium hypochlorite or bromine and sodium hydroxide, and 3-amino-5-bromopyridine can be obtained through the Hoffman rearrangement reaction.
Another method is to use 3-aminopyridine as the starting material. 3-aminopyridine is dissolved in an appropriate solvent, such as glacial acetic acid, and then bromine or bromine-containing reagents are slowly added to control the reaction temperature and dropwise rate, so that bromine atoms selectively replace hydrogen atoms at the 5th position of the pyridine ring to obtain 3-aminopyridine.
There are also those who use 5-bromo-3-nitropyridine as the starting material. First, nitro is reduced to amino groups with suitable reducing agents, such as iron, hydrochloric acid, stannous chloride, etc., and then 3-aminopyridine is obtained. However, in this process, attention should be paid to the control of the amount of reducing agent and reaction conditions to ensure the purity and yield of the product. All synthetic methods have their own advantages and disadvantages. In actual operation, it is necessary to carefully choose according to factors such as raw material availability, cost, and reaction conditions.

3-Amino-5-bromopyridine is an organic compound with unique physical properties. It often appears as a solid powder at room temperature and pressure, and its color may be white to light yellow, due to its molecular structure and crystal arrangement characteristics.
When it comes to the melting point, it is between 160-165 ° C. The value of the melting point is derived from the combination of intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. When the external temperature reaches this range, the molecule is able to overcome these forces, the lattice structure disintegrates, and then the solid state is converted to a liquid state.
In terms of boiling point, it is usually in the higher temperature range, about 300 ° C. The higher boiling point is due to the strong intermolecular force, which requires more energy to get rid of the liquid phase and turn into the gas phase.
Solubility is also an important property. It exhibits certain solubility in organic solvents, such as ethanol, dichloromethane, etc. This is because these organic solvents can form similar forces with 3-amino-5-bromopyridine molecules, following the principle of "similar miscibility". However, its solubility in water is poor, because the polarity of water molecules is not well matched with the molecular polarity of the compound, and its intramolecular hydrogen bonds and other effects limit the interaction with water molecules.
In addition, the compound has certain hygroscopicity. Because the amino group can form hydrogen bonds with water molecules in the air, it is easy to absorb water in a humid environment, which in turn affects its purity and stability. It is necessary to pay attention to moisture protection when storing.
The physical properties of 3-amino-5-bromopyridine are determined by the molecular structure. These properties are of key guiding significance for its treatment and reaction conditions in the fields of organic synthesis, drug development, etc.

3-Amino-5-bromopyridine, the price of this substance in the market often changes due to many reasons, and it is difficult to have a fixed number. Looking at the market of chemical materials in the past, changes in their prices are caused by various factors such as raw materials, supply and demand, and processes.
Let's talk about the end of the raw material first. If the starting material used in the synthesis of this pyridine has a rise and fall in price, the price of 3-amino-5-bromopyridine will also be affected by it. If the starting material is not good every day and the origin changes, resulting in a shortage of supply, the price will rise; conversely, if the supply of raw materials is abundant, the price may stabilize or decrease.
Looking at the supply and demand situation, if the market demand for 3-amino-5-bromopyridine increases sharply, such as the pharmaceutical, pesticide and other industries, and the supply is difficult to follow, the price will rise; if the demand is low, the manufacturer's inventory is overstocked, and the price will be reduced for sales.
Changes in the process are also related to the price. If the new synthetic process can improve the yield and reduce energy consumption, the cost will decrease, and the price will also decrease. On the contrary, the process is old, the cost is high, and the price is difficult to lower.
In the past market, its price may fluctuate between tens of yuan and hundreds of yuan per kilogram. However, the chemical market is constantly changing, and if you want to know the exact current price, you should consult chemical raw material suppliers, traders, or professional chemical market information platforms to obtain the actual price.

3-Amino-5-bromopyridine is an organic compound. During storage and transportation, many matters need to be paid attention to.
When storing, the first environment. When placed in a cool, dry and well-ventilated place, away from fires and heat sources. This is because of its certain chemical activity, high temperature or open flame is prone to danger. The warehouse temperature should be controlled within an appropriate range to prevent the properties of substances from changing due to excessive temperature.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because of the amino and bromine atoms in its chemical structure, it is easy to chemically react with these substances, causing danger. If it comes into contact with oxidizing agents, or causes severe oxidation reactions, or causes combustion or explosion.
Packaging is also critical, and it must be well sealed to prevent moisture absorption or reaction with air components. Use suitable packaging materials, such as glass bottles, plastic bottles, etc., and supplement them with appropriate fillers to prevent collision damage during transportation.
During transportation, follow relevant regulations and standards. Be sure to pack and unload lightly when handling to avoid damage to packaging and containers. Transportation vehicles need to be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. If a leak occurs during transportation, emergency measures should be taken promptly, such as evacuating people, isolating contaminated areas, and containing leaks with suitable materials. < Br >
3-Amino-5-bromopyridine storage and transportation, environmental control, classified storage, good packaging and transportation compliance are all critical to ensure its safety and stability.