3-Amino-5-bromo-2-hydroxypyridine

3-Amino-5-bromo-2-hydroxypyridine is an important class of organic compounds. It has a wide range of uses and is particularly critical in the field of pharmaceutical synthesis.
When Guanfu Pharmaceutical was created, this compound was often used as a key intermediate. Because the amino group, bromine atom and hydroxyl group in it have unique chemical activities, they can be cleverly connected with other molecules through various organic reactions to construct compounds with complex structures and specific pharmacological activities. For example, in the development of antimicrobial drugs, they can be introduced into the target molecular structure through carefully designed reaction steps to give the drug excellent antimicrobial properties, or to improve the targeting of the drug against specific bacteria, improve the efficacy and reduce its side effects.
In the field of pesticide chemistry, 3-amino-5-bromo-2-hydroxypyridine also plays an important role. It can be converted into pesticide ingredients with high insecticidal, bactericidal or herbicidal effects through specific synthetic pathways. Due to its special chemical structure, it can interact with specific biomolecules in pests, pathogens or weeds, interfere with their normal physiological and metabolic processes, and achieve the purpose of controlling pests. Compared with traditional pesticides, it may have higher selectivity and environmental friendliness, reducing the adverse effects on non-target organisms and the ecological environment.
Furthermore, in the field of materials science, although the application is slightly inferior to the former two, it also has potential value. Due to the molecular structure endowed with certain characteristics, or can participate in the synthesis of materials with special photoelectric properties, such as in the exploration of organic Light Emitting Diode (OLED) materials, with appropriate modification and integration, or can optimize the material's luminous efficiency, stability and other key performance indicators, for the development of new display technology.
In summary, 3-amino-5-bromo-2-hydroxypyridine, with its unique chemical structure, has shown important uses in many fields such as medicine, pesticides and materials science, and is an indispensable and important compound in the field of organic chemistry.

There are several common methods for the synthesis of 3-amino-5-bromo-2-hydroxypyridine.
First, the compound containing the pyridine ring is used as the starting material. If the appropriate substituted pyridine is selected, the bromine atom is introduced at the 5th position of the pyridine ring through halogenation reaction. During the halogenation process, the halogenation reagent, such as N-bromosuccinimide (NBS), needs to be carefully selected, and the reaction temperature, time and solvent conditions should be precisely regulated. Then, the amination reaction is carried out, and the amino group is introduced at the third position of the pyridine ring. In this step, ammonia gas, amine compounds, etc. can be used as the amino source, and the reaction is catalyzed by suitable catalysts, such as copper salts. Finally, through the hydroxylation reaction, the hydroxyl group is introduced at the second position, which can be achieved by means of base catalysis.
Second, it is a strategy for constructing the pyridine ring. For example, the prototype of the pyridine ring is constructed by condensation reaction with β-ketone esters and ammonia or amine compounds as starting materials. Subsequently, bromine atoms and hydroxyl groups are introduced at specific positions in the pyridine ring in sequence through reaction steps such as halogenation and hydroxylation, thereby achieving the synthesis of 3-amino-5-bromo-2-hydroxypyridine.
Third, a metal-catalyzed cross-coupling reaction strategy is adopted. Using a pyridine derivative containing some substituents as a substrate, through a metal catalyst, such as a palladium catalyst, it is cross-coupled with bromine-containing reagents and amino-containing reagents respectively. Bromine atoms and amino groups are introduced in a predetermined order, and then hydroxyl groups are introduced through appropriate reactions, so as to achieve the synthesis of the target product. At the time of synthesis, the control of the reaction conditions is extremely critical, such as the amount of catalyst, ligand selection, type and amount of base, reaction temperature and time, etc., all have a significant impact on the yield and selectivity of the reaction. After repeated experiments and fine optimization of reaction conditions, 3-amino-5-bromo-2-hydroxypyridine can be efficiently synthesized.

3-Amino-5-bromo-2-hydroxypyridine is one of the organic compounds. Its physical properties are unique and are described in detail by you.
The first properties of this compound are mostly solid at room temperature, and the color may be white to light yellow powder, fine and uniform. Looking at its state, the shape is fine and delicate, just like the softness of the morning fog in the mountains, and the purity of the first fall of winter snow.
The melting point is about a specific temperature range. The melting point of this compound is like the identification of its characteristics. It is accurate and unique, and the identification is an important basis. When the temperature gradually rises to its melting point, it is like ice and snow in spring, quietly changing from solid to liquid, completing the transformation of the state of matter.
Besides solubility, in water, its solubility is limited, but in organic solvents, such as ethanol, dichloromethane, etc., it has a certain solubility. Ethanol, such as babbling streams, can contain this compound moderately; dichloromethane is like a deep lake, and it can also disperse the compound to a certain extent. This solubility property is of great significance in the process of organic synthesis and separation and purification.
Its density is also an important physical property. The density is also the mass of the substance per unit volume. The density of 3-amino-5-bromo-2-hydroxypyridine determines its position and distribution in the mixed system, which is like setting the needle of the sea, allowing researchers to grasp its behavior in various environments.
As for stability, it is quite stable under conventional conditions. In extreme environments such as strong acids, strong bases or high temperatures, it is like a delicate flower in a violent wind, prone to chemical reactions, and the structure and properties can be changed.
This is a summary of the physical properties of 3-amino-5-bromo-2-hydroxypyridine. In the field of organic chemistry, these properties are like cornerstones, supporting the building of related research and applications.

3-Amino-5-bromo-2-hydroxypyridine, an organic compound with multiple unique chemical properties.
It is basic due to the presence of amino groups. The nitrogen atom in the amino group contains lone pairs of electrons, which can accept protons and form ammonium salts in acidic environments. In the case of strong acids, the amino nitrogen atom will combine with the proton to exhibit its basic properties.
In addition, the hydroxyl groups in this compound are also active. Hydroxyl hydrogen atoms can participate in the formation of hydrogen bonds and affect the physical and chemical properties of substances, such as melting point, boiling point and solubility. And the hydroxyl group can undergo a substitution reaction. If it is with a halogenated hydrocarbon under appropriate conditions, the hydroxyl oxygen atom will attack the carbon atom of the halogenated hydrocarbon, and the halogen atom will leave to form ether compounds.
The presence of bromine atoms endows the molecule with special reactivity. Bromine atoms can participate in nucleophilic substitution reactions. Under the action of nucleophilic reagents, bromine atoms can be replaced by other groups. For example, when reacting with a nucleophilic reagent containing active hydrogen, bromine atoms will be replaced by nucleophilic reagent groups.
At the same time, the pyridine ring of this compound is aromatic. Because the pyridine ring conforms to the Shocker rule, it has a stable conjugated system. This makes the molecule relatively stable and can undergo typical reactions of aromatic compounds, such as electrophil Under appropriate conditions, electrophilic reagents will attack the pyridine ring and form corresponding substitution products.
3-Amino-5-bromo-2-hydroxypyridine exhibits diverse chemical properties due to the characteristics of amino, hydroxy and bromine atoms and pyridine rings, and may have important uses in organic synthesis and other fields.

The price range of 3-amino-5-bromo-2-hydroxypyridine in the market is difficult to determine. This is due to the rapidly changing market conditions, and the price varies with many factors, such as the source of materials, the amount required, the complexity of the process, and the differences in business.
According to the previous "Tiangong Kaiwu", the price of everything depends on supply and demand and cost. In today's 3-amino-5-bromo-2-hydroxypyridine, if the material is widely distributed, easy to prepare, and few are needed, the price may be low; on the contrary, if the source is rare, and there are many people seeking it, the price will be high.
As far as I know, in the past, this product may vary from time to time, and the price per gram may range from a few gold to tens of gold. However, this is only an approximate number, and it cannot be made accurate today. To know the exact price, you should consult the chemical material suppliers, or visit the platform of chemical product trading, in order to obtain the current actual price to meet the needs.