3-amino-4-(trifluoromthyl)pyridine

3-Hydroxy-4- (trifluoromethyl) pyridine, its main uses have many aspects.
In the field of medicinal chemistry, this compound can be used as a key intermediate. The presence of a specific substituent and the presence of a specific pyridine ring endows it with unique chemical activity and structural characteristics, allowing it to derive a wide variety of biologically active substances through chemical synthesis. For example, when developing new antibacterial drugs, this can be used as a starting material to modify its structure through a series of chemical reactions, or drugs that have strong inhibitory or killing ability against specific bacteria can be prepared, adding a powerful weapon for human resistance to the invasion of pathogens.
In the field of materials science, it also has important applications. Because it contains fluorine atoms, the properties of fluorine atoms can significantly improve the properties of materials. For example, introducing it into polymer materials can improve the chemical corrosion resistance, heat resistance and weather resistance of materials. These high-performance materials are widely needed in many fields such as aerospace and automobile manufacturing, and can be used to make aircraft shells, automotive parts, etc., to adapt to harsh working environments.
In the field of pesticide research and development, it also plays an important role. It can be used as a basic structural unit for building high-efficiency and low-toxicity pesticide molecules. Using its special structure and activity, pesticides targeting specific pests or weeds can be developed, which can not only effectively control pests and diseases, ensure the yield and quality of crops, but also reduce environmental pollution and harm to non-target organisms, which is in line with the current trend of green agriculture development.
From this perspective, 3-hydroxy-4- (trifluoromethyl) pyridine has important uses in many fields such as medicine, materials, and pesticides, and has contributed greatly to the development of related industries.

3-Hydroxy-4- (trifluoromethyl) pyridine is a rather unique organic compound. Its physical properties are as follows:
Looking at its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid, but there may be slight color differences due to purity, preparation method and other factors. This substance has a certain volatility and can evaporate slowly in the air, so pay attention to ventilation conditions during operation.
When it comes to solubility, it shows good solubility in many organic solvents, such as common ethanol, ether, dichloromethane, etc., which can be mixed with it. This property makes it suitable for organic synthesis reactions, and can often be used as an intermediate to participate in various chemical reactions, because it can easily interact with other reactants in the solution system. The boiling point of
is about a specific temperature range. This temperature is affected by the surrounding environmental pressure, usually at standard atmospheric pressure, the boiling point is relatively stable. This boiling point data is of great reference value for its separation, purification and application under specific reaction conditions. For example, when purifying by distillation, the temperature needs to be precisely controlled according to the boiling point. The melting point of
also has a specific value, which characterizes the temperature conditions required for its transformation from solid to liquid. During storage and transportation, the melting point data can help determine whether its physical state changes due to temperature changes, thereby ensuring its quality and stability.
In addition, the density of the compound is also a specific value, which is related to the actual operation of material ratio, volume and mass conversion in chemical production. For example, in the preparation process, the required volume of raw materials can be accurately measured according to the density to ensure that the reaction proceeds according to the predetermined stoichiometric ratio.

To prepare 3-amino-4- (trifluoromethyl) pyridine, there are various methods. First, it can be obtained from a compound containing a pyridine ring through multi-step conversion. First, take a suitable pyridine derivative, make it react with a reagent containing trifluoromethyl under specific conditions, and introduce trifluoromethyl. In this step, a suitable reaction medium and catalyst need to be selected to promote a smooth reaction. For example, in an inert organic solvent, a metal salt is used as a catalyst to fully interact with the trifluoromethylation reagent, and then the specific position of the obtained product is modified by amination. The nucleophilic substitution reaction can be used to use ammonia or ammonia derivatives as the amino source, and the amino group can be introduced under appropriate temperature and pressure to obtain the target product.
Second, the strategy of constructing a pyridine ring is carried out. First, the pyridine ring is constructed by cyclization of small molecules containing trifluoromethyl and amino latent functional groups. For example, the enone compound containing trifluoromethyl is reacted with a nitrogen-containing nucleophile to form a key intermediate, and then the pyridine ring structure is constructed by intramolecular cyclization. In this process, it is necessary to fine-tune the reaction conditions, such as temperature, pH, etc., to ensure that the cyclization reaction proceeds in the expected direction, and to ensure that the amino group and trifluoromethyl are introduced accurately based on the target position of the pyridine ring to obtain 3-amino-4- (trifluoromethyl) pyridine.
Third, biosynthesis can be used. Using the catalytic properties of microorganisms or enzymes, specific substrates are used as starting materials, and complex metabolic pathways or enzymatic reactions in organisms can be used to selectively synthesize target compounds. Although this approach is green and environmentally friendly, it requires strict biological systems. It is necessary to screen suitable microbial strains or specific enzymes, and optimize the culture conditions and reaction parameters to improve the yield and purity of the product.

When storing and transporting 3-amino-4- (trifluoromethyl) pyridine, pay attention to the following things:
First, when storing, choose a dry, cool and well-ventilated place. If this substance encounters moisture or deteriorates due to water vapor, it will affect its quality and performance. And high temperature may also cause chemical reactions, so a cool place is important. Good ventilation can avoid the accumulation of harmful gases and ensure environmental safety.
Second, it has high packaging requirements. The packaging material used must have good sealing to prevent contact with air, moisture, etc. Commonly used airtight containers, and the container material must be compatible with the substance and do not react. For example, do not use metal packaging that will chemically react with 3-amino-4- (trifluoromethyl) pyridine, so as not to corrode the container and damage the substance itself.
Third, during transportation, ensure stability. This substance may be damaged by vibration or collision, and then leak. Therefore, the means of transportation should have shock absorbers and fixtures to ensure smooth transportation.
Fourth, this substance may be toxic and dangerous, and transportation and storage personnel need professional training to be familiar with its characteristics, safety precautions and emergency treatment methods. In the event of an accident such as leakage, it can be handled quickly and properly to minimize harm.
Fifth, storage and transportation should be kept away from fire sources, heat sources and oxidants. 3-Amino-4- (trifluoromethyl) pyridine in case of open flame, hot topic or contact with oxidants, there is a risk of combustion and explosion.
In short, in the whole process of 3-Amino-4- (trifluoromethyl) pyridine storage and transportation, it is necessary to operate in strict accordance with specifications, emphasizing safety, quality, and avoiding accidents.

Wen Jun's inquiry is about the market price of 3-amino-4- (trifluoromethyl) pyridine. The market price of this product often varies due to changes in the market, supply and demand trends, and differences in manufacturing techniques.
In the chemical industry, if the quantity is small and the quality is high, the price for experimental investigation may be high due to the high purity and the difficulty of refining. High-purity products are common in the market, and the price per gram may range from tens to hundreds of dollars. Because the preparation process involves many delicate methods, from the selection of raw materials to the control of reactions, all need to be carefully handled to obtain this high-purity product, so its price is not cheap.
If you buy a large number of industrial, considering the scale efficiency of mass production, the price per ton should be different. With the expansion of production scale, the unit cost may decrease slightly due to the collection of raw materials, equipment reuse, etc. However, this is also related to the game of market supply and demand. If there are many applicants and few suppliers, the price will tend to rise; on the contrary, if the supply exceeds the demand, the price may also have a downward trend.
And the difference between regions is also a variable of price. Policies, taxes, and logistics fees in various places can all make prices different. In a prosperous city, although there are many seekers, the convenience of logistics and the smooth flow of information may make the price relatively stable; while in remote places, due to the difficulty of logistics and the stagnation of information, the price may fluctuate.
In general, in order to know the exact price, it is necessary to consult various merchants, measure the situation over time, and consider various factors in order to obtain a relatively accurate price.