3-amino-4-iodopyridine

3-Amino-4-iodopyridine is one of the organic compounds. Its main uses are quite extensive, and its role is particularly important in the field of medicinal chemistry.
In the field of drug research and development, this compound is often a key intermediate. The unique chemical properties of Gain amino and iodine atoms give it the ability to participate in various chemical reactions. It can be skillfully spliced with other molecular fragments through organic synthesis to construct drug molecules with specific biological activities. For example, when developing new drugs targeting specific disease targets, 3-amino-4-iodopyridine can be used as a starting material to precisely modify the molecular structure through multi-step reactions to achieve ideal pharmacological activity and pharmacokinetic properties.
In the field of materials science, it is also involved. Because of the nitrogen and iodine elements in its structure, it can affect the electronic and optical properties of materials. Or it can be used to prepare materials with special optoelectronic properties, such as organic Light Emitting Diode (OLED) materials. By introducing this compound, the luminous efficiency and stability of the material can be optimized, which will contribute to the development of display technology.
In addition, in organic synthetic chemistry research, 3-amino-4-iodopyridine is an important synthetic building block, providing the possibility for the synthesis of complex organic molecules. Chemists can take advantage of the nucleophilicity of their amino groups and the replaceability of iodine atoms to carry out various reactions, such as coupling reactions, nucleophilic substitution reactions, etc., to achieve the diversification of organic molecules, expand the boundaries of organic synthesis, and assist in the creation and performance research of new organic compounds.

The synthesis method of 3-amino-4-iodine pyridine has been investigated by many parties throughout the ages. The following are several common methods.
First, pyridine is used as the starting material. First, pyridine is halogenated under specific conditions to introduce iodine atoms. Usually, a suitable halogenating agent, such as iodine elemental substance, can be used in combination with a suitable oxidizing agent, and the reaction is carried out in a suitable solvent and temperature, so that the iodine atom selectively replaces the hydrogen atom at a specific position on the pyridine ring to obtain 4-iodine pyridine. Then, 4-iodine pyridine is aminated. 3-Amino-4-iodopyridine can be prepared by the method of aminolysis, using ammonia gas as the amino source to replace the iodine atom of 4-iodopyridine with the amino group under the conditions of high temperature and high pressure and the presence of a catalyst. This route step is relatively clear, but the halogenation and amination conditions need to be precisely controlled to obtain a higher yield.
Second, the cyclization reaction is carried out with other compounds containing amino and iodine atoms as the starting materials. For example, select compounds with suitable carbon chains and substituents to construct pyridine rings through intramolecular cyclization. Such methods require clever design of the structure of the starting compound, with the help of suitable reaction conditions and catalysts, to promote the formation of intramolecular rings and the formation of the pyridine structure of the target product. Although this approach may be streamlined, the synthesis of the starting materials may be difficult and the reaction conditions are quite high.
Third, 3-aminopyridine is used as the raw material. First, the 3-aminopyridine is operated to protect the amino group to prevent the amino group from being affected in the subsequent reaction. Appropriate protective groups, such as acyl groups, are used to protect the amino group. Then the pyridine ring is iodized, and suitable iodizing reagents and reaction conditions are selected to introduce iodine atoms into the fourth position of the pyridine ring. Finally, the protective group of the amino group is removed, and 3-amino-4-iodopyridine can be obtained after a series of reaction treatments. This method focuses on the protection and deprotection of the amino group, and the optimization of the reaction conditions at each step has a significant impact on the purity and yield of the product.
The above synthetic methods have their own advantages and disadvantages. According to the actual demand, the availability of raw materials and the controllability of reaction conditions, the appropriate method should be weighed to prepare 3-amino-4-iodopyridine.

3-Amino-4-iodopyridine, this substance is an organic compound with specific physical properties. Its shape is mostly solid, and its stability is still good at room temperature.
Looking at its color state, it is often white to light yellow crystalline powder, which can be identified and easy to detect. Smell it, or have a slight special smell, but it is not pungent and intolerable.
When it comes to the melting point, the melting point is about 134-138 ° C. At this temperature, the solid will gradually melt into a liquid state. Although the data on the boiling point are rarely detailed, its structure can be inferred from its structure compared with similar compounds. Its boiling point or higher temperature range can be inferred, due to intermolecular forces.
In terms of solubility, it has a certain solubility in common organic solvents such as dichloromethane and N, N-dimethylformamide (DMF). In dichloromethane, due to the formation of appropriate forces between molecules and dichloromethane molecules, it can be well dispersed and dissolved. In water, the solubility is very small, and its molecular polarity is not well matched with water molecules, making it difficult to blend with water.
Although the density data is difficult to determine, it is inferred from the type and number of atoms in the structure that its density may be slightly higher than that of water. This is because the relative atomic weight of iodine atoms is large, resulting in an increase in molecular weight, which in turn affects the density. < Br >
The physical properties of 3-amino-4-iodopyridine are of great significance in organic synthesis and other fields. Its melting point characteristics help to purify and separate, and its specific solubility is convenient for participating in reactions in different reaction systems, providing an important basis for chemical research and production practice.

3-Amino-4-iodopyridine is an important compound in the field of organic chemistry. It has significant applications in many fields, such as medicinal chemistry, material science, etc. As for its market price, it is difficult to give an exact value, because it is affected by many factors.
The first to bear the brunt, the production process is one of the key factors. If the preparation process is complex, requires multiple steps of reaction, and the yield of each step is limited, or expensive reagents and catalysts are used, the production cost will inevitably be high, which will lead to an increase in market prices. On the contrary, if there is a simple and efficient production process, the cost will be reduced and the price may be more affordable.
Furthermore, the following pairs of supply and demand in the market have a deep impact on the price. If the demand for 3-amino-4-iodopyridine surges in a certain period in industries such as drug research and development, but the supply cannot keep up in time, showing a state of shortage, the price is bound to rise. On the contrary, if the market demand is weak and the supply is sufficient, the price may have a downward trend.
In addition, the price fluctuation of raw materials cannot be ignored. If the price of the starting material required for the synthesis of this compound fluctuates due to factors such as scarcity of resources and production constraints, it will also be transmitted to the price of 3-amino-4-iodopyridine.
Again, the purity requirements of the product also determine its price. High-purity 3-amino-4-iodopyridine is often used in areas that are extremely sensitive to impurities, such as high-end drug research and development. Its preparation is difficult, so the price is much higher than that of ordinary purity products.
From the past market situation, the price may vary from time to time, or range from a few yuan to several hundred yuan per gram. However, if you want to know the exact market price, you should consult the relevant chemical reagent suppliers in detail, or refer to the recent chemical product transaction data to obtain more accurate price information.

3-Amino-4-iodopyridine is an organic compound. During storage and transportation, there are several things to pay attention to.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Because it may be sensitive to humidity and temperature, high temperature and humid environment, it is easy to cause its deterioration. Therefore, it is appropriate to choose a place where both temperature and humidity can be controlled. If the temperature can be maintained between 15 ° C and 25 ° C, and the humidity is about 40% - 60%, it is more suitable. And should be placed separately from oxidizing agents, acids, alkalis and other substances. Due to the chemical properties of 3-amino-4-iodopyridine, it is easy to chemically react with them, which will damage its own quality and even cause danger.
As for transportation, be sure to ensure that the packaging is complete and well sealed. During transportation, prevent collisions and vibrations to avoid package damage and leakage. If it is transported by road, a qualified transportation company should be selected, and the transportation vehicles should also be equipped with corresponding emergency treatment equipment and protective equipment. If it is transported by rail or air, it is necessary to strictly follow the transportation rules and standards formulated by the relevant departments, and truthfully declare the nature and quantity of the goods and other information.
In conclusion, during the storage and transportation of 3-amino-4-iodopyridine, care should be taken to ensure its quality and transportation safety.