3-Amino-4-chloropyridine

3-Amino-4-chloropyridine is one of the organic compounds. It has unique physical properties, which are described in detail by you.
In terms of its appearance, it is mostly white to light yellow crystalline powder at room temperature and pressure. This state is easy to identify and easy to handle in many chemical operations.
Talking about the melting point, it is between 107-111 degrees Celsius. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. This specific melting point is of great significance in the purification, identification and control of related chemical reactions of compounds. The melting points of different compounds vary, which can be used as an important basis for discrimination.
Its solubility is also a key property. 3-Amino-4-chloropyridine is slightly soluble in water, but has good solubility in organic solvents such as ethanol, dichloromethane, acetone, etc. This property determines its application in the selection of chemical reaction systems and product separation. In the field of organic synthesis, select a suitable solvent to dissolve the compound, so that the reaction can proceed smoothly.
Furthermore, its stability cannot be ignored. Under normal storage conditions, in a dry and cool place, 3-amino-4-chloropyridine can remain relatively stable. When exposed to strong oxidizing agents, strong acids, strong bases and other chemicals, the stability may be affected, which can easily lead to chemical reactions and cause changes in its own structure.
The physical properties of this compound lay the foundation for its application in organic synthesis, medicinal chemistry and many other fields. Knowing its appearance, melting point, solubility and stability, chemists can skillfully use it to design and implement various chemical reactions to prepare the desired target products.

3-Amino-4-chloropyridine is one of the organic compounds. It has many unique chemical properties and is widely used in the field of organic synthesis.
In terms of its alkalinity, the presence of amino groups in the molecule makes it alkaline. The nitrogen atom in the amino group has a lone pair of electrons, which can accept protons and can form salts in acidic media. This property allows it to react with acids to generate corresponding salts. This reaction is often used in organic synthesis to separate, purify and identify such compounds.
Furthermore, the chlorine atom on the halogenated pyridine ring has higher reactivity. Due to the influence of the electronic effect of the pyridine ring, chlorine atoms are easily attacked by nucleophiles and undergo nucleophilic substitution reactions. Nucleophiles can attack the carbon atoms attached to chlorine atoms, causing the carbon-chlorine bond to break, and then forming new organic compounds. This reaction provides an effective way for the construction of various nitrogen-containing organic compounds, such as reacting with nucleophiles such as alcohols and amines, to prepare pyridine derivatives with different substituents.
And amino groups can also participate in many reactions. It can be used as a nucleophilic reagent to condensate with carbonyl compounds such as alcaldes and ketones to form imines. Under appropriate conditions, the imine product can be further converted into other functionalized organic molecules, which greatly expands the kinds of compounds derived from 3-amino-4-chloropyridine in organic synthesis.
In addition, the pyridine ring itself is also aromatic, endowing the compound with certain stability. However, its aromaticity is slightly different from that of the benzene ring. The electronegativity of the nitrogen atom on the pyridine ring affects the distribution of the electron cloud on the ring, making the pyridine ring more prone to electrophilic substitution than the benzene ring, and the reaction check point is mostly at the β position of the pyridine ring. This property also provides a basis for the compound to participate in specific organic reactions. In conclusion, the chemical properties of 3-amino-4-chloropyridine are rich and diverse, and by virtue of the characteristics of amino groups, chlorine atoms and pyridine rings, it plays an important role in the field of organic synthesis chemistry, providing powerful tools for the creation of new organic materials and pharmaceutical intermediates.

The common synthesis methods of 3-amino-4-chloropyridine are indeed key issues in the field of organic synthesis. To obtain this compound, there are several commonly used methods as follows.
First, 4-chloropyridine-3-formic acid is used as the starting material. First, 4-chloropyridine-3-formic acid is co-heated with sulfinyl chloride. This step is to convert the carboxyl group to acid chloride. This reaction is violent, and the temperature needs to be carefully controlled. It is well ventilated and operated. After the acid chloride is formed, an alcohol solution of excess ammonia is added. Ammonia and acid chloride undergo nucleophilic substitution reaction to form 4-chloropyridine-3-formamide. This amide is then reduced in an inert solvent such as anhydrous ether with a strong reducing agent such as lithium aluminum hydride to obtain 3-amino-4-chloropyridine. This process needs to be strictly anhydrous and oxygen-free to avoid the risk of decomposition of lithium aluminum hydride in contact with water.
Second, 3-nitro-4-chloropyridine is used as the starting material. Placing it in a suitable solvent, such as ethanol, adding an appropriate amount of iron powder and hydrochloric acid, the iron powder will gradually reduce the nitro group to amino group in an acidic environment, which is a classic iron powder reduction method. However, the post-treatment of this reaction is slightly complicated, and impurities such as iron mud need to be filtered to remove, and then extracted and distilled to purify the product.
Third, palladium-catalyzed coupling reaction can also be used. With suitable halogenated pyridine derivatives and amino-containing reagents, under the combined action of palladium catalyst, ligand and base, the carbon-nitrogen bond can be constructed, and then 3-amino-4-chloropyridine can be synthesized. This method has relatively mild conditions and good selectivity. However, the cost of palladium catalyst is quite high, and the reaction equipment and operation requirements are also strict. It is necessary to precisely control the reaction conditions, such as temperature, reaction time and the amount of each reagent, in order to achieve good yield and purity.
The above synthesis methods have their own advantages and disadvantages. In practical application, the appropriate method needs to be carefully selected according to many factors such as raw material availability, cost considerations, and product purity requirements.

3-Amino-4-chloropyridine is used in various fields. It is highly relied on in the genus of medicine and chemical industry. Because of its unique structure and active chemical properties, it can be used as a key intermediate to prepare a variety of drugs. Such as antibacterial and anti-inflammatory drugs, all rely on its participation in the synthesis, making great contributions to human health.
In the field of pesticide chemistry, this compound also has extraordinary performance. Using it as a raw material, it can produce high-efficiency pesticides, which can remove pests, protect crops, protect the fertility of farmers and mulberry, and contribute to the prosperity of agriculture.
Furthermore, in the field of materials science, 3-amino-4-chloropyridine has also emerged. Due to its special chemical properties, it can be used to synthesize special materials, such as materials with unique electrical and optical properties. It has potential applications in electronics, optical instruments, etc., or can contribute to the progress of science and technology.
In the field of organic synthetic chemistry, it is often a weapon in the hands of chemists. With its activity check point, it can trigger a variety of chemical reactions, build complex organic molecular structures, promote the development of organic synthetic chemistry, and expand the boundaries of chemical research. In conclusion, 3-amino-4-chloropyridine has shown important functions in many fields such as medicine, pesticides, materials, and organic synthesis, and is an indispensable substance in the field of chemistry.

The market price range of 3-amino-4-chloropyridine varies with time, place and quality, and it is difficult to have a fixed number. In the past, the price of this product in the city mostly depended on the supply and demand situation, the difficulty of preparation and the difference between the manufacturer.
I have heard that those with high quality may have high prices in the city. If the quantity is small and urgent, the price will also be high. However, if the preparation is easy, when the supply exceeds the demand, the price will decrease.
In the past, or there are merchants selling this product, the price per gram may be between a few yuan and tens of yuan. However, in the chemical industry market, the situation changes, the price of raw materials, and the innovation of technology can all affect its market price.
If raw materials are scarce and preparation costs rise, the price will also rise. On the contrary, if the process is refined, the yield is greatly increased, and the supply is abundant, the price may be lower.
And different regions, due to different logistics, taxes and fees, the price is also different. Prosperous commercial ports, convenient logistics, or because of competition, the price is slightly flat; remote places, transportation is difficult, costs are accumulated, and the price may be high.
Therefore, if you want to know the exact market price, you must carefully investigate the current market and consult merchants before you can get it.