3-Amino-2-methylamino-6-methoxypyridine dihydrochloride

3-Amino-2-methylamino-6-methoxypyridine dihydrochloride, this is an organic compound. It has many unique chemical properties.
Looking at its structure, the pyridine ring is the core, and the amino group, methylamino group and methoxy group connected to it all significantly affect its properties. The presence of amino groups gives this compound a certain alkalinity. The nitrogen atom in the capped amino group contains lone pairs of electrons, which can accept protons and is easy to form salts in acidic environments, which is why it can form dihydrochloride.
Methylamino is also a power supply group, which can enhance the electron cloud density of the pyridine ring, affect its reactivity, and make the electrophilic substitution reaction more likely to occur. Under specific conditions, the nitrogen atom of the methylamino group can also participate in the reaction and exhibit a variety of chemical behaviors.
Methoxy is a strong power supply group, which can increase the electron cloud density of the pyridine ring adjacent and para-position. Therefore, in the electrophilic substitution reaction, it can guide the substituent into the adjacent and para-position.
From the perspective of physical properties, after the formation of dihydrochloride salts, its water solubility is usually enhanced. Due to the increase in the degree of ionization of the compound after salt formation, the force between the compound and the water molecules is enhanced, and it is easier to disperse in
In addition, this compound has a wide range of uses in the field of organic synthesis, often as a key intermediate for the preparation of complex organic molecules with specific biological activities or functions. With the reactivity of each group it contains, it can undergo a series of chemical reactions to form new carbon-carbon bonds or carbon-hetero bonds, thereby achieving the synthesis of the target product.

3-Amino-2-methylamino-6-methoxypyridine dihydrochloride is an important chemical substance that is widely used in many fields.
First, in the field of pharmaceutical chemistry, it is often used as a key intermediate. The synthesis of many drugs relies on its unique chemical structure to construct specific active groups. By chemically modifying and derivatizing it, new drug molecules with different pharmacological activities can be created, opening up a broad path for drug research and development, and helping to find drugs with more curative effects and lower side effects.
Second, in the field of organic synthetic chemistry, it is an indispensable building block. Because it contains multiple active checking points, it can participate in a variety of chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., to achieve the construction of complex organic molecules, and to contribute significantly to the expansion of the diversity and complexity of organic synthesis, laying the foundation for the synthesis of various functional organic materials.
Third, in the field of materials science, after proper treatment and transformation, it can be introduced into polymer materials or functional materials to give the material special electrical, optical or chemical properties, so as to meet the needs of special functional materials in fields such as electronic devices and optical sensors.
Fourth, in biochemical research, it can be used as a synthetic raw material for biological probes or markers. Due to its structural properties, it can specifically interact with certain biomolecules, and through labeling and tracking, scientists can deeply explore the biochemical processes and molecular mechanisms in living organisms.
In summary, 3-amino-2-methylamino-6-methoxypyridine dihydrochloride plays a key role in many fields such as drugs, organic synthesis, materials, and biochemistry, and is of great significance to promoting scientific research and technological development in various fields.

To prepare 3-amino-2-methylamino-6-methoxypyridine dihydrochloride, there are various methods. 6-methoxy-2-methylamino-3-nitropyridine is often used as the starting material. After reduction, 3-amino-2-methylamino-6-methoxypyridine can be obtained, and then interact with hydrochloric acid to obtain the target 3-amino-2-methylamino-6-methoxypyridine dihydrochloride.
In the reduction step, the method of catalytic hydrogenation can be adopted. Take 6-methoxy-2-methylamino-3-nitropyridine and dissolve it into a suitable solvent, such as alcohols, such as methanol, ethanol, or ethyl acetate and other organic solvents. Then, add suitable catalysts, such as palladium carbon (Pd/C), platinum carbon (Pt/C) genus. Under suitable temperature and pressure, hydrogen is used to gradually reduce the nitro group to amino group. This process needs to be controlled by temperature, so as not to cause side reactions to occur if the temperature is too high, and the pressure needs to be appropriate to ensure the smooth reaction. After the reaction is completed, the catalyst is filtered off, and the solvent is distilled under reduced pressure to obtain a crude product of 3-amino-2-methylamino-6-methoxypyridine, which can be purified by recrystallization to obtain a more pure product.
Chemical reduction method can also be used. For example, iron powder, zinc powder and other metals, reduce 6-methoxy-2-methylamino-3-nitropyridine in an acidic medium. 6-methoxy-2-methylamino-3-nitropyridine is placed in a suitable reactor with metal powder and acid (such as hydrochloric acid), stirred and heated to carry out the reaction. After the reaction, after separation and purification, 3-amino-2-methylamino-6-methoxypyridine can also be obtained.
Wait to get 3-amino-2-methylamino-6-methoxypyridine, which can be dissolved into an appropriate amount of solvent, such as ethanol, water, etc., and slowly add hydrochloric acid dropwise to make the salt-forming reaction occur. Add it dropwise and stir for a period of time to make the reaction complete. Then, by evaporating the solvent or cooling down the crystallization, 3-amino-2-methylamino-6-methoxypyridine dihydrochloride can be obtained, and then the product with high purity can be obtained by refining methods such as recrystallization.

3-Amino-2-methylamino-6-methoxypyridine dihydrochloride is a chemical substance. During storage and transportation, many matters need to be paid attention to.
Its nature may be more active, and it is quite sensitive to temperature and humidity. Therefore, when storing, it should be placed in a cool, dry and well-ventilated place. If the temperature and humidity are too high, it may cause its properties to change or even deteriorate. Do not place it in direct sunlight to prevent chemical reactions caused by light and damage its quality.
During transportation, it is also necessary to ensure that the packaging is intact. The packaging of this substance must be strong and can withstand certain external shocks to prevent leakage. Once it leaks, it will not only cause material damage, but also pose a threat to the safety of the environment and personnel. And the means of transportation should be clean, dry, and free of other impurities that may react with it.
Furthermore, because of its certain chemical properties, storage and transportation should be kept away from fire sources, heat sources, strong oxidants, strong acids and alkalis and other substances. These substances come into contact with it, or cause severe reactions, such as combustion, explosion and other serious consequences.
Operators should also take protective measures and be equipped with appropriate protective equipment, such as protective gloves, goggles, protective clothing, etc. To prevent inadvertent contact and cause harm to the body. In conclusion, when storing and transporting 3-amino-2-methylamino-6-methoxypyridine dihydrochloride, it is necessary to exercise caution and follow relevant norms and requirements to ensure safety and quality.

"Tiangong Kaiwu" was written by Song Yingxing in the Ming Dynasty. At that time, the naming and market pricing concepts of chemical substances were very different from those of today. However, according to today's market information, I can use quaint words as the king to come to the market price range of 3-Amino-2-methylamino-6-methoxypyridine dihydrochloride.
The price of this compound in today's chemical reagent market varies depending on purity, packaging specifications, suppliers and purchase quantities. If it is an ordinary laboratory-grade purity, the common packaging specifications such as 1 gram, the price may be in the tens of yuan. And scientific research-grade high-purity products, such as 98% purity or more, the price of 1 gram may exceed 100 yuan. If the purchase volume reaches the kilogram level, the price per gram may drop to tens of yuan due to the scale effect.
And because the chemical market price often fluctuates with the cost of raw materials and the relationship between supply and demand, if the supply of raw materials is tight due to the scarcity of raw materials, the price will rise; if the market demand is weak and the supply exceeds demand, the price will drop. And there are also differences in markets in different regions. In economically developed places, the logistics is convenient and the competition is sufficient, and the price may be slightly lower; in remote areas, the price may be slightly higher due to factors such as transportation costs.
In short, the market price of 3 - Amino - 2 - methylamino - 6 - methoxypyridine dihydrochloride is between tens of yuan and over 100 yuan for 1 gram, or tens of yuan per gram when purchasing in large quantities. The actual price needs to be consulted with the supplier according to the specific procurement situation.