3-Amino-2-fluoropyridine

3-Amino-2-hydroxybenzoic acid, its main uses are as follows:
This compound is used in the field of medicine and is often a key intermediate for the synthesis of many drugs. Due to the structure of amino and hydroxybenzoic acid, it has unique chemical and biological activities. For example, in the preparation of some antipyretic and analgesic drugs, by virtue of its structural characteristics, it can participate in specific reactions, build the core skeleton of the drug, and then endow the drug with corresponding physiological effects.
In the dye industry, 3-amino-2-hydroxybenzoic acid can be used as an important raw material for the synthesis of dyes. Because of its structure, the dye can show rich color and good dyeing properties. After a specific chemical reaction, it is combined with other compounds to make various dyes, which are widely used in dyeing processes such as textiles and leather to meet different color requirements.
In the field of organic synthesis, it is an important building block for organic synthesis. Because it contains active groups such as amino and carboxyl groups, it can be connected with other organic compounds through various reactions such as esterification and amidation to build complex organic molecular structures, laying the foundation for the synthesis of organic materials with special functions, such as some organic materials with optical and electrical properties. < Br >
In the field of cosmetics, certain derivatives of 3-amino-2-hydroxybenzoic acid or compounds synthesized based on them can be added to cosmetics due to their antioxidant and antibacterial properties, which can protect the skin and prolong the shelf life of products.

There are many synthetic methods for 3-amino-2-hydroxybenzoic acid, all of which have unique methods and uses. The following are common synthetic paths:
** Using anthranilic acid as the starting material **:
Anthranilic acid is acylated to obtain the corresponding amide derivative. Usually acetyl chloride, acetic anhydride, etc. are used as acylating reagents. In the presence of suitable bases (such as pyridine), acylation reactions are prone to occur. Subsequently, at low temperatures and specific alkaline conditions, such as in aqueous sodium hydroxide solution, the amide group can be rearranged by Hoffman to obtain 3-amino-2-hydroxybenzoic acid. This rearrangement process requires careful control of the reaction conditions. Due to factors such as temperature and alkali concentration, the yield and purity of the product are greatly affected.
** Salicylic acid is used as the starting material **:
Salicylic acid is first nitrified to obtain 5-nitrosalicylic acid. In this step of nitrification, the mixed acid of nitric acid and sulfuric acid is often used as the nitrifying reagent. Conditions such as temperature and acid ratio need to be precisely controlled to avoid the formation of polynitro compounds. Then, 5-nitrosalicylic acid is reduced, and gold such as iron powder and zinc powder belongs to the acidic medium, or the nitro group is converted into an amino group by catalytic hydrogenation, and 3-amino-2-hydroxybenzoic acid is finally obtained. The catalytic hydrogenation method requires suitable catalysts, such as palladium carbon, etc., and the reaction is carried out in a high-pressure hydrogen environment, which requires high equipment, but the product purity is better.
** Using phthalic anhydride as the starting material **:
Phthalic anhydride is first aminolyzed to obtain o-carboxybenzamide. In this step, the reaction is heated in ammonia to achieve aminolysis. Then, the o-carboxybenzamide is rearranged by Hoffman and converted to o-aminobenzoic acid. After that, the hydroxylation reaction, such as sodium nitrite and sulfuric acid, generates diazonium salts at low temperatures, and then hydrolyzed, hydroxyl groups can be introduced to obtain 3-amino-2-hydroxybenzoic acid. The formation and hydrolysis of diazonium salts require low temperature operation to prevent the decomposition of diazonium salts and affect the formation of products.
The above methods have their own advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider factors such as raw material cost, reaction conditions, product yield and purity to choose the most suitable synthesis path.

3-Amino-2-hydroxybenzoic acid is an organic compound. It has the following physical properties:
Under normal conditions, it is white to light yellow crystalline powder, fine and pure, free of variegation and foreign matter. This form is easy to identify and operate, and it is easy to accurately weigh and add in many experiments and industrial processes.
Smell it, almost odorless, only very light odor, in the use environment, it will not bring pungent or uncomfortable taste, and it is quite advantageous in production and use scenarios, and can create a good working atmosphere.
Measure its melting point, about 170-175 ° C. Melting point is an important physical property of a substance. This temperature range can help to distinguish its purity. For those with high purity, the melting point range is narrow and close to the theoretical value; for those with impurity, the melting point is reduced and the range is widened.
Its solubility is also a key characteristic. Slightly soluble in cold water, however, the solubility in hot water is gradually better. This characteristic allows it to be dissolved and separated at different temperatures. In organic solvents, such as ethanol, ether, etc., it also has a certain solubility. This characteristic provides convenience for its organic synthesis and extraction processes. It can select the solvent according to the needs to achieve its dissolution, reaction or separation.
When it comes to stability, it is quite stable at room temperature and pressure, and can be stored for a long time without significant deterioration. However, when exposed to strong oxidizing agents, strong acids, and strong bases, it is prone to chemical reactions and changes in structure or properties. Therefore, when storing and using, it is necessary to avoid contact with such substances. It should be placed in a cool, dry, and well-ventilated place to prevent deterioration and ensure quality and performance.

In today's world, it is very difficult to determine the price of 3-amino-2-hydroxypyridine between shops. The price often varies with various factors, such as supply and demand, manufacturing costs, and the rise and fall of the market.
The situation of supply and demand has a huge impact on prices. If there are many people in the market who want this 3-amino-2-hydroxypyridine, and there are few people who supply it, the price will rise. For example, when people are hungry, there is a shortage of food and the people compete for food, and the price of food is expensive. On the contrary, if this product is flooded in the market, and there are few applicants, the price will drop, and it will be like the valley of abundant years. Although the quality is high, the price will not be high.
Manufacturing cost is also the key. The manufacture of 3-amino-2-hydroxypyridine requires all kinds of raw materials, and the price of raw materials fluctuates, so the cost will follow. In addition, the technique of manufacturing is also related to cost. If the technique is refined and the labor is saved, the cost may be reduced; if the technique is clumsy and the labor is complicated, the cost will increase. If the cost changes, the price of the market will remain unchanged?
Furthermore, the rise and fall of the market also affects its price. When the market is prosperous, all industries are prosperous, and there are many people who need this product for use, and the price also rises accordingly. If the market is bleak, and all industries are sluggish, and those who seek it are scarce, the price may not avoid falling.
From this perspective, if you want to know the market price of 3-amino-2-hydroxypyridine, you must carefully observe supply and demand, costs, and market conditions. However, I do not know all the things in real time, so it is difficult to say exactly how much the price is. But the business in the city is ever-changing, and the price is also impermanent. If you want to get a firm price, you must also consult the merchants, or observe the situation carefully in the market.

3-Amino-2-hydroxybenzoic acid requires attention to many matters during storage and transportation.
One is related to storage. This substance should be placed in a cool, dry and well-ventilated place. Because it is quite sensitive to humidity and temperature, if the ambient humidity is high, it is easy to cause deliquescence, which will affect its quality and stability; if the temperature is too high, it may cause chemical reactions and cause it to deteriorate. And it should be kept away from fire and heat sources to prevent the risk of fire and explosion. At the same time, it needs to be stored separately from oxidants, acids, alkalis, etc. The chemical properties of 3-amino-2-hydroxybenzoic acid are active, and contact with the above substances is prone to chemical reactions or dangerous consequences.
Second, about transportation. Be sure to ensure that the packaging is complete and sealed before transportation to prevent it from leaking due to package damage during transportation. During transportation, it is necessary to strictly follow the relevant regulations on the transportation of hazardous chemicals and select transportation enterprises and vehicles with corresponding qualifications. Transportation vehicles should be equipped with necessary fire protection equipment and leakage emergency treatment equipment to deal with emergencies. During transportation, attention should also be paid to avoid sun exposure, rain exposure, and prevent high temperature and humid environments from adversely affecting them.
In short, whether it is storing or transporting 3-amino-2-hydroxybenzoic acid, it is necessary to strictly follow relevant norms and requirements, and attach great importance to safety and quality, so as to ensure that the substance does not cause problems during circulation and ensure the safety of personnel and the environment.