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What are the main uses of 3-amino-2-cyanopyridine?
3-Amino-2-cyanopyridine has a wide range of uses. In the field of pharmaceutical synthesis, it is an important intermediate. With this material, many biologically active compounds can be prepared, or antibacterial agents, or antiviral drugs, which are beneficial to human health and a lot. Craftsmen in pharmaceutical research and development often rely on this as a foundation to build delicate molecular structures and obtain new drugs with outstanding curative effects.
In the field of materials science, it also has its uses. It can participate in the preparation of materials with special functions, such as those with special optical and electrical properties. These materials can be used in electronic devices, optical instruments and many other aspects to help the progress of related technologies.
In the field of organic synthetic chemistry, 3-amino-2-cyanopyridine is a commonly used building block. With its unique chemical properties, Fangjia of organic synthesis can design and synthesize complex and diverse organic compounds. This is of great significance in expanding the types of organic compounds and exploring new chemical synthesis paths. It can derive a series of novel compounds through various chemical reactions, such as nucleophilic substitution and cyclization reactions, injecting new vitality into the development of organic chemistry.
What are the physical properties of 3-amino-2-cyanopyridine?
3-Amino-2-cyanopyridine, this is an organic compound. It has many physical properties, let me tell them one by one.
When it comes to appearance, 3-amino-2-cyanopyridine is often in the state of white-like to light yellow crystalline powder, which is delicate in appearance and relatively pure in color.
Its melting point is quite critical, about 162-166 ° C. In this temperature range, the substance gradually melts from solid to liquid. This melting point characteristic is an important reference index for the identification and purification of this compound.
Solubility is also an important physical property. 3-Amino-2-cyanopyridine is slightly soluble in water, but it exhibits good solubility in organic solvents such as ethanol and dichloromethane. This property makes it possible to select suitable organic solvents according to different reaction requirements to help the reaction proceed smoothly.
In addition, the stability of the compound cannot be ignored. Under conventional storage conditions, in a dry and cool place, 3-amino-2-cyanopyridine can remain relatively stable. However, when exposed to extreme conditions such as strong acid, strong base or high temperature, its chemical structure may change, resulting in changes in properties.
In summary, the physical properties of 3-amino-2-cyanopyridine, such as appearance, melting point, solubility, and stability, are of great significance in many fields such as organic synthesis and drug development, providing a key basis for related scientific research and production work.
3-amino-2-cyanopyridine chemical synthesis methods
3-Amino-2-cyanopyridine is also an organic compound. The synthesis method has various ways in the past.
One method is to use 2-cyanopyridine as the starting material and nitrate to obtain 2-cyano-3-nitropyridine. In this step, in a suitable reaction vessel, 2-cyanopyridine is placed in a mixed acid system of sulfuric acid and nitric acid, and the temperature, reaction time and other conditions can be controlled to obtain 2-cyano-3-nitropyridine. Then, the nitro group of 2-cyano-3-nitropyridine is reduced to an amino group in an acidic medium with a reducing agent, such as iron powder, zinc powder, etc., to obtain 3-amino-2-cyanopyridine.
The second method can start from 2,3-dichloropyridine. Shilling 2,3-dichloropyridine and cyanide reagents, such as potassium cyanide, in the presence of suitable solvents and catalysts, cyano substitution reactions occur to obtain 2-cyano-3-chloropyridine. Then, the chlorine atom of 2-cyano-3-chloropyridine is replaced by an amino group with ammonia or amine reagents. After optimizing the reaction conditions, 3-amino-2-cyanopyridine can also be prepared.
The third method uses the rearrangement reaction of pyridine derivatives. Select specific pyridine derivatives, induce specific reagents and reaction conditions, and undergo intramolecular rearrangement to form 3-amino-2-cyanopyridine. This process requires a deep understanding of the reaction mechanism and precise regulation of the reaction conditions in order to make the reaction proceed as expected.
The above synthesis methods each have their own advantages and disadvantages, and must be carefully selected according to the actual required product purity, cost, difficulty of reaction conditions, etc., in order to achieve the best synthesis effect.
What is the price range of 3-amino-2-cyanopyridine in the market?
I look at the market price range of "3-amino-2-cyanopyridine" you are inquiring about. This is a matter in the field of fine chemicals. Market prices often vary depending on quality, supply and demand, source and purchase quantity.
In the context of "Tiangong Kaiwu", although there is no confirmation of this chemical, it can be used for its observation and price analysis. Looking at today's commercial market, if the purchase quantity is small, it is only for experimental or research and development needs, and the price may be high. Due to small preparation, the cost is shared more, and the price per unit may reach several hundred yuan per gram.
If it is purchased in large quantities for industrial grade, the manufacturer can consider the efficiency of scale, and the cost can be reduced. However, it also depends on the quality level. Generally speaking, those with high purity are more expensive, and those with low purity are slightly cheaper. When purchasing in large quantities, the price per kilogram may range from several thousand yuan to ten thousand yuan.
If this "3-amino-2-cyanopyridine" is a rare or newly developed product, the research and development cost is high, and the initial price must be high. However, with technological familiarity and capacity expansion, the price may gradually drop. If market demand is strong, supply is in short supply, and the price also tends to rise; if supply exceeds demand, the price will fall. It is based on its market price range, with a small amount of hundreds of yuan per gram, and a large amount of thousands of yuan to ten thousand yuan per kilogram. It is actually affected by various factors.
What are the precautions in the use of 3-amino-2-cyanopyridine?
3-Amino-2-cyanopyridine is an important organic compound that is widely used in many fields. However, when using it, there are several key precautions to be paid attention to.
First safety protection. This compound is toxic and irritating, and contact may endanger the human body. During operation, be sure to wear appropriate protective equipment, such as protective gloves, goggles, and protective clothing, to prevent skin contact and eye splashing. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention according to specific conditions.
Times and storage conditions. Store it in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its sensitivity to humidity and temperature, improper storage or deterioration will affect the use effect. At the same time, it should be stored separately from oxidants, acids, etc., and mixed storage should be avoided to prevent dangerous chemical reactions.
The other is the operating specification. The use process must be carried out in a fume hood to ensure good ventilation and reduce the inhalation of harmful gases. Precisely control the usage and reaction conditions, because of its active chemical nature, the reaction conditions are different or cause different reaction results. Before the experimental operation, you should be familiar with the relevant reaction principles and operation procedures to avoid accidents caused by mistakes.
In addition, waste disposal should not be ignored. Waste after use cannot be discarded at will, and needs to be properly disposed of in accordance with relevant regulations. In general, it should be handed over to a professional waste treatment agency and follow specific procedures for disposal to avoid pollution to the environment.
In short, the use of 3-amino-2-cyanopyridine, safety is paramount, and strict compliance with operating specifications and storage and disposal requirements can ensure the safety of personnel and the smooth progress of experiments or production.