3-amino-2-chloropyridine

3-Amino-2-chloropyridine is an important class of organic compounds. Its main usage can be widely used in many fields such as medicine, pesticides, materials, etc.
In the field of medicine, this compound is often a key intermediate for synthesizing drugs. Due to its unique structure, it can be combined with other molecules through many chemical reactions, so it can create drugs with specific pharmacological activities. For example, it can be used to build a specific chemical framework to develop drugs targeting specific disease targets, which is of great help to the treatment of diseases.
As for pesticides, 3-amino-2-chloropyridine also plays a key role. It may be used as an important raw material for the synthesis of new pesticides. With reasonable molecular design and chemical modification, the prepared pesticides may have many advantages such as high efficiency, low toxicity, environmental protection, etc., which can effectively control crop diseases and insect pests and ensure agricultural harvests.
In the field of materials, this compound may participate in the preparation of materials with special properties. Because of its amino and chlorine atoms, it can endow materials with unique physical and chemical properties, such as improving material stability, conductivity, optical properties, etc., so as to meet the special needs of materials in different fields. In conclusion, 3-amino-2-chloropyridine has shown great application potential in medicine, pesticides, materials, etc. due to its unique chemical structure, and is an indispensable and important substance in the field of organic synthesis.

The synthesis method of 3-amino-2-chloropyridine, through the ages, many parties have their own wonderful methods. First, using 2-chloropyridine as the starting material, the nitro group is introduced into the pyridine ring through nitration reaction, and then the nitro group is reduced to the amino group by suitable reducing agents, such as iron powder, zinc powder or catalytic hydrogenation, etc., to obtain 3-amino-2-chloropyridine. In this process, the nitration reaction needs to pay attention to the control of the reaction conditions. The temperature and the proportion of reactants are all related to the purity and yield of the product. The choice of reducing agent also needs to be weighed. Although the catalytic hydrogenation is clean and efficient, it requires quite high equipment. Iron powder and zinc powder also have low cost in principle, but the post-treatment is slightly complicated.
Second, 2-chloro-3-nitropyridine can be used as a catalyst to hydrogenate and reduce nitro groups in a hydrogen atmosphere to directly obtain the target product. This path is relatively simple, and the catalyst palladium carbon can be recycled and reused, which is in line with the concept of green chemistry. However, palladium carbon is expensive, and the reaction requires strict conditions such as sealing the reactor and hydrogen supply.
Third, using 2,3-dichloropyridine as a raw material and reacting with ammonia under specific conditions, the chlorine atom is replaced by an amino group, and 3-amino-2-chloropyridine can also be obtained. In this reaction, the concentration of ammonia, reaction temperature and time all have a significant impact on the reaction process. If the concentration is too high or too low, and the temperature is not suitable, it may lead to side reactions and affect the quality of the product.
All these synthesis methods have advantages and disadvantages. It is necessary to consider the actual needs, such as product purity, cost budget, equipment conditions, etc., and choose the best one to use, in order to efficiently synthesize 3-amino-2-chloropyridine.

3-Amino-2-chloropyridine is a kind of organic compound. Its physical properties are quite important, let me explain in detail for you.
First of all, its appearance, under room temperature and pressure, 3-amino-2-chloropyridine is mostly white to light yellow crystalline powder. This morphology is easy to observe and identify, and is a key feature of preliminary identification in laboratory and industrial production.
and its melting point, about 87-91 ℃. Melting point, the temperature limit for a substance to change from solid to liquid. This specific melting point value plays a pivotal role in the purification and identification of compounds. By accurately measuring the melting point, the purity of the substance can be determined. If the melting point is consistent with the standard value, the purity is higher; if there is a deviation, it may contain impurities.
The boiling point is the boiling point, which is about 272 ° C. The boiling point is the temperature at which the liquid turns into a gas, and this value is related to the volatility and stability of the compound under heating conditions. A higher boiling point indicates that a higher temperature is required to gasify it. In the reaction or separation process of high temperature environment, the boiling point property is crucial.
In terms of solubility, 3-amino-2-chloropyridine is slightly soluble in water, but can be soluble in organic solvents such as ethanol, ether, and chloroform. This solubility property is of great significance in chemical synthesis, extraction separation and other operations. In organic synthesis reactions, selecting an appropriate solvent according to its solubility can promote the reaction and improve the reaction efficiency; in the separation process, the difference in solubility in different solvents can be used to achieve effective separation from other substances.
In addition, the compound has a certain odor, although not strong and pungent, it also has its own unique smell. This is an olfactory identification feature, which can also be used for preliminary judgment in actual operation.
In summary, the physical properties of 3-amino-2-chloropyridine, including appearance, melting point, boiling point, solubility, and odor, are essential basic information in many fields of chemical research and industrial production, and have far-reaching implications for its related operations and applications.

3-Amino-2-chloropyridine is on the market, and its price range is difficult to determine. The price of 3-amino-2-chloropyridine often varies due to multiple factors, such as the price of raw materials, the method of preparation, the supply and demand situation, and the quality.
Looking at the past market conditions, if it is an ordinary grade for industrial use, when purchasing in bulk, the price per ton may be in the tens of thousands. However, this is not a fixed number, and the price of raw materials fluctuates. If the price of raw materials required for preparation is high, the price of 3-amino-2-chloropyridine will also rise. In addition, if the preparation method is complicated and the cost is high, the price will also rise.
If it is high purity for laboratory use, the price per gram may range from tens to hundreds of yuan. This is due to high purity requirements, complicated purification techniques, and increased costs.
And supply and demand conditions have a great impact on its price. If market demand surges and supply is limited, the price will tend to rise; conversely, if demand is low and supply is large, the price may drop. Quality differences are also related to price. Those with high purity and few impurities must be higher than ordinary ones.
In order to know the exact price range of 3-amino-2-chloropyridine, it is necessary to carefully observe the current market conditions and consult suppliers to obtain a more accurate number.

3-Amino-2-chloropyridine is a crucial intermediate in the field of organic synthesis, and is widely used in the pharmaceutical, pesticide, dye and other industries. Many manufacturers are involved in the production of this compound.
In China, such as Shandong Jincheng Pharmaceutical Group joint stock company, which has a good reputation in the production of pharmaceutical intermediates, and is very likely to involve the production of 3-amino-2-chloropyridine. The company has strong technical strength, advanced production technology, and high quality intermediates, which are trusted by many enterprises in the pharmaceutical industry.
Another example is Jiangsu Yangnong Chemical Group Co., Ltd., as a leader in the field of pesticides, has rich experience in the production of fine chemical intermediates. 3-Amino-2-chloropyridine may be an important part of its pesticide production chain. With its own R & D and production advantages, it may be able to produce high-quality products.
There are also many well-known manufacturers overseas. Sigma-Aldrich Company in the United States is famous for providing a wide variety of chemical reagents and intermediates. Its product Quality Standards are strict, and 3-Amino-2-chloropyridine is also in its product line, supplying high-quality raw materials for global scientific research institutions and enterprises.
BASF Company in Germany, as a giant in the chemical industry, has a deep foundation in the production of fine chemicals. With advanced technology and strict quality control, its production of 3-amino-2-chloropyridine may occupy an important share in the global market and is widely used in various related industries.
The above is only part of the manufacturer of 3-amino-2-chloropyridine, and many other manufacturers in the industry are also involved in the production of this product, jointly promoting the development of related industries.