3-AMINO-2-CHLORO-6-METHOXYPYRIDINE

3-Amino-2-chloro-6-methoxypyridine, this substance has a wide range of uses. In the field of medicine, it is an important pharmaceutical intermediate. Due to the construction of many drug molecules, it is necessary to use this as a starting material and undergo a series of chemical reactions to synthesize drugs with specific pharmacological activities. For example, some antibacterial drugs, with their unique chemical structure, participate in the reaction, and after modification and transformation, can generate pharmaceutical ingredients that have inhibitory or killing effects on specific pathogens.
In the field of pesticides, it also plays a key role. It can be used to prepare pesticides, fungicides and other pesticide products. Its chemical properties enable it to react with other compounds to generate substances that have a control effect on crop diseases and pests. Such as participating in the synthesis of specific pesticides, with its structural characteristics, it has an impact on the nervous system of pests or physiological and metabolic processes, so as to achieve the purpose of insect protection and agricultural protection.
In the field of materials science, it also has certain applications. Or it can be used as an intermediate in the synthesis of functional materials, through specific reactions, endowing materials with unique properties, such as some materials with special optical and electrical properties. During the synthesis process, 3-amino-2-chloro-6-methoxypyridine may play an indispensable role in helping to optimize and improve material properties.

3-Hydroxy-2-chloro-6-methoxypyridine is an organic compound with the following physical properties:
It is mostly in solid form at room temperature. Due to the strong interaction between molecules, the molecules are closely arranged, so it is in a solid state. The melting point of this compound is about [X] ° C. When the temperature rises to this melting point, the solid substance will transform endothermic into a liquid state. The specific melting point can be used as the basis for identification and purity judgment. The melting point of pure products is fixed, and the melting point of impurities is reduced and the melting range becomes wider.
The boiling point of this substance is about [X] ° C. At this temperature, the liquid compound absorbs enough energy to overcome the intermolecular force and becomes gaseous and escapes. The boiling point is affected by the molecular structure and intermolecular forces, which determine the boiling point value.
In terms of solubility, 3-hydroxy-2-chloro-6-methoxypyridine has good solubility in organic solvents such as ethanol and acetone. Because these organic solvents can form interactions such as hydrogen bonds and van der Waals forces with the compound, it can help it disperse in the solvent. However, the solubility in water is poor, because the hydrophobic groups in the molecule account for a large proportion, the ability to form hydrogen bonds with water is weak, and the polar environment of water interacts unfavorably with the hydrophobic groups, making it difficult to dissolve in water. < Br > 3-Hydroxy-2-chloro-6-methoxypyridine is usually white to pale yellow powder or crystal in appearance. The color and morphology are affected by the synthesis process and impurity content. It is white at high purity, containing impurities or differences in synthesis conditions. The color may be deepened and the morphology may also change.
The density of this compound is about [X] g/cm ³. The density reflects the unit volume mass and is determined by the molecular mass and the compactness of molecular accumulation. This value is of great significance in the design of chemical production, storage and transportation.

The question asked by Wen Jun is whether the chemical properties of 3-amino-2-chloro-6-methoxy pyridine are stable. The stability of this substance depends on its molecular structure, chemical bond properties and the environment in which it is located.
Looking at its molecular structure, amino groups, chlorine atoms and methoxy groups are all connected to the pyridine ring. The pyridine ring is aromatic and stable, and its π electron cloud forms a closed conjugate system, which reduces the molecular energy. However, amino groups have electron-donating effects, while chlorine atoms and methoxy groups have double effects of electron-withdrawing and electron-donating. These substituents will affect the distribution of the pyridine ring electron cloud.
From the perspective of chemical bonds, the bond energies of carbon-nitrogen, carbon-chlorine, and carbon-oxygen bonds are different. The carbon-chlorine bond is relatively active, and under certain conditions, the chlorine atom is easily replaced by nucleophilic reagents. The nitrogen atom of the amino group has lone pairs of electrons, which can participate in chemical reactions, such as reacting with acids to form salts, or undergoing nucleophilic substitutions under appropriate conditions. Although the oxygen atom of the methoxy group has the effect of electron conjugation, which increases the density of adjacent and para-electron clouds, under certain conditions, the methoxy group may also undergo reactions such as cracking.
As for the external environment, if this substance encounters high temperature, the thermal motion of the molecules will intensify, and the vibration of the chemical bond will increase, which may cause it to decompose or react. In an acid-base environment, amino groups can react with acids, and pyridine rings may also undergo ring-opening reactions under strongly acidic or strongly basic conditions. If there are oxidants or reducing agents, redox reactions may also be initiated due to the variable oxidation states of some atoms in the molecule.
In summary, the chemical properties of 3-amino-2-chloro-6-methoxypyridine are not absolutely stable. Under certain conditions, chemical reactions can occur in some parts of its structure, which will affect its stability.

To prepare 3-amino-2-chloro-6-methoxypyridine, there are various methods.
First, the compound containing the pyridine ring is started, and it can be easily obtained through halogenation, amination, methoxylation and other series. First, the pyridine ring is exposed to the halogenating reagent under specific conditions and chlorine atoms are introduced. This step requires a suitable halogenating agent and reaction environment. For example, a specific iron halide is used as a catalyst. In the hydrogen halide atmosphere, the temperature and time are well-studied to ensure that the chlorine atom falls accurately in the expected position. Next, the technique of amination is performed, and the specific group is replaced with an ammonia source, and the amino group is introduced. The choice of ammonia source, such as liquid ammonia and ammonia gas, requires a matching solvent and catalysis to promote the smooth reaction. After that, methoxylation reagents, such as methylation reagents, are combined with alkoxides to introduce methoxy groups into the ring to achieve the construction of the target molecule.
Second, it may start with simple small molecules and go through a multi-step condensation and cyclization method. First, small molecules containing nitrogen, chlorine and methoxy groups are used as bases, and under suitable reagents and conditions, a condensation reaction is carried out to gradually build the skeleton of the pyridine ring. In this process, the reaction sequence and the proportion of reagents are all key. For example, certain small molecules such as aldodes, ketones, and amines, under the catalysis of acids or bases, condensate and polymerize, and undergo a series of transformations such as dehydration and rearrangement to form a pyridine ring structure. After modification and adjustment, each substituent is precisely in place to obtain 3-amino-2-chloro-6-methoxypyridine.
Third, there are also explorers of biosynthesis. With the catalysis of microorganisms or enzymes, the synthesis is completed in a mild environment. Select microbial strains or enzymes with specific catalytic activities, feed them with specific substrates, and biocatalyze the synthesis of target pyridine derivatives through complex metabolic pathways in the body. This green, mild, but the microbial and enzyme screening, culture and regulation of the reaction system requirements are quite high, still need to be further studied to achieve practical.

My question is about the market price range of 3-amino-2-chloro-6-methoxypyridine. The price of this chemical in the market often varies for many reasons.
First, the price of raw materials has a great impact on it. If the price of the various raw materials used in the synthesis of this pyridine rises or falls, the price of this pyridine will also change accordingly. Suppose the production of raw materials varies, resulting in a shortage or excess supply, which can make the price fluctuate.
Second, the method of preparation is related to the cost. If a new method can save more raw materials, reduce energy consumption, and improve yield, the cost will drop, and the price will also drop. On the contrary, if the preparation is difficult, rare agents are required, or the equipment requirements are strict, the cost will be high, and the price will also be high.
Third, the market demand is also critical. If the demand for pyridine in a certain industry increases sharply, such as the pharmaceutical and pesticide industries, the demand will exceed the supply, and the price will rise. On the contrary, if there is no more demand, the supply will exceed the demand, and the price will drop.
Fourth, the current situation rules also play a role. If there are new regulations, such as environmental protection and safety, that limit production or increase additional costs, the price will also be affected.
In summary, the price of 3-amino-2-chloro-6-methoxypyridine is roughly between tens of yuan and hundreds of yuan per kilogram. However, this is only a rough figure. To know the exact price, ask the chemical raw material supplier, or look at the recent market transaction details to determine the actual price.