3-Amino-2-chloro-5-(trifluoromethyl)pyridine

3-Hydroxy-2-chloro-5- (trifluoromethyl) pyridine, which has a wide range of uses. In the field of medicine, it is a key intermediate, and many drug synthesis relies on it to build the basic structure. For example, in the preparation of some antibacterial drugs, with its unique chemical structure, it participates in the reaction and endows the drug with specific antibacterial activity and stability, which is of great significance to resist bacterial infection.
In the field of pesticides, it is a key component in the synthesis of high-efficiency pesticides. Due to its fluorine and other special groups, synthetic pesticides have strong biological activity, high selectivity and good environmental compatibility. Like some new insecticides, it can be used to precisely act on specific physiological targets of pests, kill pests efficiently, and reduce the impact on non-target organisms to ensure ecological balance.
In the field of materials science, it has also emerged. After chemical modification and polymerization, polymer materials with special properties can be prepared. For example, polymers containing this structure may have excellent thermal stability, chemical stability and electrical properties, and are used in high-end fields such as electronic devices, aerospace, etc., to improve the comprehensive performance of materials and meet special environmental needs.
Due to its special structure and activity, this compound plays a key role in many fields such as medicine, pesticides and materials science, and promotes technological innovation and product upgrading in related industries.

3-Amino-2-chloro-5- (trifluoromethyl) pyridine, this is an organic compound. Its physical properties are as follows:
Under normal temperature and pressure, it is mostly colorless to light yellow liquid, or crystalline solid, depending on the specific purity and environmental conditions.
Smell its odor, often with a special pungent odor and pungent smell. This odor can be an important characteristic when identifying the compound.
In terms of its solubility, it exhibits good solubility in organic solvents such as ethanol, ether, dichloromethane, etc. Due to the molecular structure characteristics of the compound, it can form a suitable interaction with the organic solvent molecules, so it can be well dissolved in it. However, the solubility in water is relatively poor. Edge water is a highly polar solvent, and the interaction with the compound molecules is weak, making it difficult to break the force between the compound molecules to dissolve it.
Measure its melting point and boiling point. The melting point and boiling point values depend on the purity of the compound and the pressure environment in which it is located. Generally speaking, such pyridine derivatives containing specific functional groups have relatively high boiling points. Due to the existence of interactions such as hydrogen bonds and van der Waals forces between molecules, more energy needs to be supplied to overcome these forces in order to transform them from liquid to gaseous. The melting point also varies depending on the degree of regular arrangement of molecules and the magnitude of intermolecular forces, usually within a certain temperature range.
Looking at its density, compared with water, its density is either greater than or less than that of water, which is related to the relative mass of molecules and the degree of accumulation between molecules. If the relative mass of molecules is large and closely packed, the density is greater than that of water; otherwise, it is less than that of water.
The above physical properties are of crucial significance in the synthesis, separation, purification and application of the compound, which can help chemists better control the relevant chemical reactions and processes.

The chemical properties of 3-hydroxy-2-chloro-5- (trifluoromethyl) pyridine are relatively stable. The reason is that from a structural point of view, the pyridine ring itself has a certain stability. The pyridine ring is a six-membered heterocycle with aromatic properties. This aromatic system can give a more uniform distribution of the electron cloud, thereby enhancing the stability of the molecule.
In this compound, hydroxy (-OH), chlorine atom (-Cl) and trifluoromethyl (-CF 🥰) substituents have a specific impact on the electron cloud distribution of the pyridine ring. The hydroxyl group has an electron-donor conjugation effect. Although its electron-donor ability will change depending on the connection method with the pyridine ring, it can increase the electron cloud density on the pyridine ring in general, which is conducive to stabilizing the pyridine ring to a certain extent. Chlorine atoms have an electron-withdrawing induction effect due to their large electronegativity, but they also have a weak electron-donor conjugation effect. The two effects are combined, and the effect on the stability of the pyridine ring is within an acceptable range without overly weakening its stability. Trifluoromethyl is a strong electron-withdrawing group, which will significantly reduce the electron cloud density on the pyridine ring. However, the aromatic structure of the pyridine ring is firmly based, which can resist this effect to a certain extent and maintain the relative stability of the overall structure.
In addition, from the perspective of spatial structure, the relative positions of these substituents on the pyridine ring do not produce too strong spatial repulsion between them, which also contributes to the stability of the molecular structure. Therefore, the chemical properties of 3-hydroxy-2-chloro-5- (trifluoromethyl) pyridine are relatively stable due to various factors such as electronic effects and spatial structure.

To prepare 3-amino-2-chloro-5- (trifluoromethyl) pyridine, the method is as follows:
First, a suitable pyridine derivative is used as the starting material. After halogenation reaction, chlorine atoms are introduced. Under specific reaction conditions, the halogenation reagent interacts with the pyridine substrate to precisely regulate the reaction check point and conditions, so that the chlorine atom just falls at the No. 2 position.
Then proceed with the amination step. Select the appropriate amination reagent, and use the appropriate reaction medium and catalyst to promote the amino group to successfully replace the group at the corresponding position, achieving the purpose of introducing the amino group at the No. 3 position.
As for the introduction of trifluoromethyl, a specific trifluoromethyl-containing reagent can be used to react with the pyridine intermediate in a suitable reaction environment, so that the trifluoromethyl is connected to the 5th position. Each step of the reaction needs to pay attention to the fine regulation of the reaction conditions, such as temperature, pH, reaction time, etc., to ensure the high efficiency of the reaction and the purity of the product. After the reaction, the pure 3-amino-2-chloro-5- (trifluoromethyl) pyridine is obtained through separation and purification methods, such as distillation, recrystallization, column chromatography, etc.
Second, there are other ways. A pyridine framework containing trifluoromethyl can be constructed first, and then chlorine atoms and amino groups can be introduced in sequence. First, the raw material containing trifluoromethyl is used to build a pyridine ring through a series of reactions, and then the halogenation and amination reactions are carried out in sequence. During the operation, the conditions of each reaction link should be carefully controlled to achieve the ideal reaction effect and product yield. In this way, it can be used as a method for preparing 3-amino-2-chloro-5- (trifluoromethyl) pyridine.

I look at what you said about "3-hydroxy-2-chloro-5- (trifluoromethyl) pyridine", which is an important organic compound in the field of fine chemicals. Its market price range is influenced by many factors.
The first to bear the brunt is the cost of raw materials. The synthesis of this compound requires specific starting materials. If the raw materials are scarce or difficult to prepare, the price will be high. If the fluorinated raw materials required for the preparation of this pyridine derivative are not easy to obtain and the cost will rise, the price of the product will also rise.
Furthermore, the difficulty of the production process also affects the price. If the synthesis path is complicated, multi-step reactions are required, and the reaction conditions of each step are harsh, and the requirements for reaction equipment and technology control are very high, the production cost will increase, and the market price will naturally not be low. For example, some steps need to be carried out at low temperature, high pressure or under the action of a specific catalyst. If the operation is not careful, the yield and purity will be affected, which will be reflected in the price.
The market supply and demand relationship is also a key factor. If the compound is in high demand in the pharmaceutical, pesticide and other industries, but the supply is relatively insufficient, the price will tend to rise; conversely, if the market is saturated and the supply is excessive, the price will fall.
Taking into account many factors, "3-hydroxy-2-chloro-5- (trifluoromethyl) pyridine" is in the market price range, roughly ranging from a few hundred to several thousand yuan per kilogram. However, this is only a rough estimate, and the actual price should change according to the specific market conditions.