3-Amino-2-chloro-4-methylpyridine

3-Hydroxy-2-chloro-4-methylpyridine is an important organic compound. Its main uses are quite extensive, and it has key applications in various fields such as medicine, pesticides and materials.
In the field of medicine, it is often a key intermediate for the synthesis of many drugs. Due to its specific chemical structure, it can be chemically modified to meet the needs of different drug targets. For example, the synthesis of some antibacterial drugs relies on it to build a specific molecular skeleton, which helps the drug interact with key enzymes or receptors in bacteria, blocking the growth and reproduction path of bacteria, and achieving antibacterial effect.
In the field of pesticides, this compound also plays an important role. It can be reasonably designed and modified to produce high-efficiency pesticides, fungicides and other pesticide products. Because it can precisely act on the specific physiological processes of pests or pathogens, it interferes with their normal growth, development and metabolism, thus effectively preventing and controlling crop diseases and insect pests, and ensuring crop yield and quality.
In the field of materials, 3-hydroxy-2-chloro-4-methylpyridine can participate in the synthesis of special polymer materials. The active groups in its structure can react with other monomers to give the material unique properties, such as improving the heat resistance and chemical corrosion resistance of the material, broadening the application range of the material, showing potential application value in high-end fields such as aerospace and electronics.
In summary, 3-hydroxy-2-chloro-4-methylpyridine plays an indispensable role in the fields of medicine, pesticides and materials due to its unique chemical structure and reactivity, and is of great significance to the development of related industries.

3-Amino-2-chloro-4-methylpyridine is an organic compound, which is widely used in the chemical and pharmaceutical fields. Its physical properties are as follows:
Looking at it, it is mostly solid at room temperature, and the color may vary from white to light yellow, which is closely related to its purity. Pure products are often lighter in color, but may be darker when they contain impurities.
Smell it, it has a special smell, but the specific smell is difficult to describe accurately, or varies due to individual differences in smell, but it is mostly irritating or unique smell.
Measure its melting point, because the molecular structure causes the intermolecular force to be specific, and the melting point is within a certain range. According to experimental measurements and literature records, it is roughly in a specific temperature range. This temperature characteristic is of great significance for its separation, purification and identification. In chemical production, the purity of the product can be judged by melting point measurement.
Measure its boiling point. Under specific pressure conditions, it will boil into a gaseous state when it reaches a certain temperature. The boiling point reflects the volatility of the substance. The boiling point of 3-amino-2-chloro-4-methylpyridine or relatively high, because there are various forces in the molecule, which requires more energy for gasification.
As for solubility, in organic solvents, such as common ethanol, acetone, etc., there is a certain solubility. Due to the similar miscibility principle, its molecular structure is compatible with organic solvents, and intermolecular interactions can be formed. However, the solubility in water is relatively small, because it is not a typical hydrophilic structure, and it interacts weakly with water molecules.
In terms of density, there may be differences compared to water, and the specific value depends on accurate measurement. This property is crucial when it comes to liquid-liquid separation or material proportion control in reaction systems.
In summary, 3-amino-2-chloro-4-methylpyridine has unique physical properties, and in-depth understanding can help to better control its behavior and process in practical applications such as chemical engineering and pharmaceutical synthesis.

3-Amino-2-chloro-4-methylpyridine is an organic compound. The stability of its chemical properties needs to be viewed from multiple aspects.
In terms of structure, the pyridine ring system is quite stable because of its aromaticity. The aromatic system decreases in energy due to delocalization of π electrons, which stabilizes the molecule. The pyridine ring of this compound is also protected by this property, making its overall structure framework solid.
However, the presence of amino groups, chlorine atoms and methyl groups in the molecule adds variables to its chemical properties. Amino groups have certain electron-giving properties and can participate in many chemical reactions. It can neutralize with acids to form corresponding salts. At the same time, amino groups can be used as nucleophiles to participate in nucleophilic substitution reactions, which is of great significance in organic synthesis. Such reactivity reflects from the side that its chemical properties are not completely stable, and it is easy to change when encountering suitable reactants.
Although chlorine atoms are not active functional groups, they can exhibit specific reactivity due to the distribution of electron clouds in the pyridine ring. Under certain conditions, chlorine atoms can be replaced by nucleophiles to change the molecular structure.
methyl is relatively stable and mainly plays the role of electronic effect and steric hindrance. After it introduces methyl into the molecule, it can affect the electron cloud density of surrounding atoms, change its reactivity, and occupy a certain space, which affects the interaction between molecules.
Generally speaking, the chemical properties of 3-amino-2-chloro-4-methylpyridine are stable to a certain extent, which is derived from the aromatic properties of the pyridine ring. However, due to the existence of functional groups such as amino groups and chlorine atoms, chemical reactions can occur under specific conditions and are not absolutely stable. Its stability depends on the specific environment and the reactants encountered.

To prepare 3-amino-2-chloro-4-methylpyridine, there are many methods, and each has its own advantages and disadvantages, which need to be selected according to the actual situation. The following are common synthesis methods:
First, 2-chloro-4-methylpyridine is used as the starting material. First, the nitro group is introduced into the appropriate position of the pyridine ring through nitrification reaction. This step requires careful selection of nitrifying reagents and reaction conditions to ensure precise positioning of nitro groups. Commonly used nitrifying reagents such as mixed acid (mixed nitric acid and sulfuric acid), the reaction temperature and time conditions also need to be carefully adjusted. Then the obtained nitro compound is reduced to an amino group with a suitable reducing agent, such as iron powder, hydrochloric acid system, or catalytic hydrogenation method, in which the catalytic hydrogenation method requires a catalyst with good activity and selectivity, such as palladium carbon, etc. This process requires high reaction equipment, pressure and temperature control.
Second, 2-chloro-4-methylniacin is used as raw material. First, the carboxyl group is converted into a leaving group, such as esterification into an ester group, select a suitable alcohol and catalyst, and use sulfuric acid as a catalyst to heat and reflux to promote the reaction. Then the ester group is reacted with the ammonia source to form an amide through aminolysis. The aminolysis conditions need to consider the concentration of the ammonia source, the reaction temperature and time. Finally, through the Hoffmann degradation reaction, the amide is converted into an amino group. This reaction requires the participation of bromine or chlorine and base to strictly control the reaction process and avoid side reactions.
Third, the construction strategy of pyridine ring is adopted. Using small molecules containing appropriate nitrogen, chlorine and methyl as raw materials, the pyridine ring is constructed through multi-step reaction. For example, 1,3-dicarbonyl compounds are cyclized with ammonia sources and chlorinated reagents under suitable catalyst and reaction conditions to form pyridine rings. This process requires strict requirements on the reaction sequence, the proportion of reagents and the separation and purification of reaction intermediates, and involves multi-step reactions. The total yield may be affected by each step reaction.

Wen Jun inquired about the market price of "3-hydroxy-2-chloro-4-methylpyridine". This is a product in the field of fine chemicals, and its price varies for many reasons.
First, the price of raw materials. If the starting materials required for the synthesis of this pyridine, such as specific halogenated hydrocarbons, nitrogen-containing compounds, etc., change in price due to changes in origin, season, and supply and demand, the price of this pyridine will also follow. If the raw materials are scarce, the price will increase; if the raw materials are abundant, the price may decrease.
Second, the method of preparation. Different process routes have different costs. The simple and efficient method can reduce the cost and make the price low; the complex and consumable method can lead to high cost and high price. And the catalysts and reaction conditions required in the preparation also affect the cost and price.
Third, the demand of the market. If the demand for pyridine in the pharmaceutical, pesticide, material and other industries increases sharply, the supply exceeds the demand, and the price will rise; if the demand is flat and the supply is surplus, the price may fall.
Fourth, the quality is divided. Those with high purity and few impurities are mostly used in high-end fields, and the price is not cheap; those with slightly lower purity and inferior quality, or for general purposes, the price is correspondingly lower.
Looking at the current market, the price of this "3-hydroxy-2-chloro-4-methylpyridine" is between hundreds and thousands of yuan per kilogram due to different quality and batch. However, the market situation is changing rapidly. If you want to know the exact price, you need to consult the merchants specializing in chemical raw materials or observe the latest market conditions on the chemical trading platform to obtain a certain number.