3-amino-2-bromopyridine

3-Amino-2-bromopyridine is an important chemical substance in the field of organic synthesis. Its main use is in drug synthesis. Due to its special chemical structure, it can be used as a key intermediate to produce many biologically active drug molecules. For example, in the creation process of some antibacterial drugs and anti-tumor drugs, 3-amino-2-bromopyridine plays an indispensable role. Through the chemical reactions it participates in, it can precisely construct the specific structure of drug molecules, and then give drugs the required pharmacological activity.
Furthermore, in the field of materials science, it can also be seen. It can be introduced into polymer materials through specific chemical reactions, so that the materials can obtain unique properties, such as improving the electrical and optical properties of the materials, or enhancing the stability of the materials.
In addition, in the research and practice of organic synthetic chemistry, 3-amino-2-bromopyridine is also a commonly used synthetic block. Chemists can derive a series of organic compounds with diverse structures based on their structural characteristics, relying on various organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc., injecting vitality into the development of organic synthetic chemistry, expanding the creation path of new compounds, and promoting academic research and technological innovation in related fields. In conclusion, 3-amino-2-bromopyridine has important uses in many fields such as drugs, materials and organic synthesis, and has contributed greatly to the progress of related industries and the in-depth of scientific research.

3-Amino-2-bromopyridine is also an important compound in organic synthesis. There are several common methods for its synthesis.
First, 2-bromopyridine is used as the starting material. First, 2-bromopyridine is nitrified to introduce nitro groups into the pyridine ring. This nitrification reaction needs to be carefully controlled at temperature, and a suitable nitrifying agent, such as mixed acid (a mixture of nitric acid and sulfuric acid), is selected. After nitrification, 2-bromopyridine can be obtained. Subsequently, the nitro group is reduced. Commonly used reducing agents include iron and hydrochloric acid systems, hydrogen and palladium-carbon catalyst systems, etc. Taking the system of iron and hydrochloric acid as an example, under suitable reaction conditions, the nitro group can be reduced to an amino group to obtain 3-amino-2-bromopyridine.
Second, 2,3-dibromopyridine can also be used as a raw material. React 2,3-dibromopyridine with an ammonia source, such as liquid ammonia or ammonia water, under suitable reaction conditions. This reaction is often carried out in an autoclave to ensure that the concentration of ammonia is suitable for the reaction temperature and pressure. During the reaction, ammonia replaces one of the bromine atoms to obtain 3-amino-2-bromopyridine.
Third, 3-aminopyridine is used as the starting material. First protect 3-aminopyridine, such as protecting the amino group with a suitable protective group to prevent it from being affected in the subsequent reaction. After that, the 2-position on the pyridine ring is brominated. Brominated reagents such as bromine and N-bromosuccinimide (NBS) can be selected. After the bromination reaction is completed, the protective group of the amino group is removed, and finally 3-amino-2-bromopyridine is obtained.
All this synthesis method has its own advantages and disadvantages, and it needs to be carefully selected according to factors such as actual demand, availability of raw materials, cost and reaction conditions.

3-Amino-2-bromopyridine is a kind of organic compound. Its physical properties are quite unique.
Looking at its properties, it is mostly in a solid state at room temperature, and its structure is relatively stable due to intermolecular forces. Its color is often white to pale yellow, and the formation of this color is related to the distribution and transition of electron clouds in the molecular structure.
When it comes to the melting point, it is within a certain range, and this value is extremely critical for the identification and purification of this compound. The melting point depends on the strength of intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. The presence of amino and bromine atoms in 3-amino-2-bromopyridine molecules makes the intermolecular forces change, which in turn affects the melting point.
In terms of solubility, in organic solvents, such as ethanol, dichloromethane, etc., there is a certain solubility. This is due to the principle of similarity and miscibility, the structure of organic molecules is similar to that of organic solvent molecules, which can form intermolecular interactions and promote dissolution. However, the solubility in water is relatively limited, and the polarity of the cover is not enough to form a strong enough interaction with water molecules.
In addition, its density is also a specific value, reflecting the degree of close packing of molecules. The size of the density is related to the molecular weight and the distance between molecules. The density of 3-amino-2-bromopyridine can be accurately determined under specific conditions. This data is related to the measurement of materials and the ratio of reaction systems in chemical production and experimental operations.
Its vapor pressure also has a corresponding value at a certain temperature. The size of the vapor pressure is related to the volatility of the compound. The vapor pressure of 3-amino-2-bromopyridine is relatively low, indicating that its volatility is not very strong, and it is difficult to volatilize to the gas phase at room temperature and pressure.

What is the price of 3-amino-2-bromopyridine in the city? Try to imitate the text of "Tiangong Kaiwu".
The price of various things in the city often varies according to time, place, supply and demand. 3-amino-2-bromopyridine is also a material used in chemistry. Its price range also follows this rule. In the past, if the supply and demand were calm, its price was still stable. However, the world is impermanent, or due to the abundance of raw materials, or the change of process, its price fluctuates every time.
When the raw materials are rich, the preparation method is refined, and the production force is saved, the price will tend to be flat and good. It may be sold in the market for hundreds of dollars per mole. If raw materials are scarce, procurement is difficult, and preparation techniques are difficult to implement, resulting in sparse output, and there are many people in need, the price will rise. Or rise to thousands of gold per mole, also unknown.
And in different places, the price is also different. The capital of Dayi, the merchants are convergent, the logistics is convenient, and the price may be flat. In remote towns, it is difficult to transfer, and there are losses, so the price is high.
In addition, the rules of trade and the difference in quality are all related to the price. Therefore, if you want to know the exact price, you must carefully consider the supply and demand in time and place, and the quality specifications.

3-Amino-2-bromopyridine is an important compound in organic chemistry. Its storage conditions are crucial and related to the stability and quality of this compound.
Bear the brunt, it needs to be placed in a cool place. If the cover temperature is too high, it is easy to cause chemical reactions and cause the compound to deteriorate. And it should be stored in a dry place, away from moisture. Because moisture is easy to interact with 3-amino-2-bromopyridine, or cause structural changes, the activity is impaired.
Furthermore, it should be stored in a sealed container. In this way, it can prevent contact with air. Oxygen, carbon dioxide, etc. in the air may react with the compound. A sealed container can prevent the intrusion of external substances and maintain its chemical stability.
In addition, it is also crucial to keep away from fire sources and oxidants. 3-Amino-2-bromopyridine has certain chemical activity, and may react violently or even explode when exposed to fire sources or oxidants, endangering safety.
When storing, also pay attention to the material of the container. Choose a material that does not react with 3-Amino-2-bromopyridine, such as a specific glass or plastic material. This can ensure that the compound is not affected by the material of the container and maintains its inherent characteristics for a long time.
In summary, the storage of 3-amino-2-bromopyridine requires a cool, dry, sealed place, far from the fire source and oxidant, and a suitable container material to ensure the quality and safety of this compound.