3-Amino-2-bromo-5-fluoropyridine

3-Amino-2-bromo-5-fluoropyridine is one of the organic compounds and has important uses in many fields.
First, in the field of medicinal chemistry, it is often a key intermediate. Taking the creation of antibacterial drugs as an example, the unique structure of this compound can be chemically modified to add specific functional groups, so that it has a targeted effect on specific pathogens. The cell wall and metabolic pathways of capping pathogens are specific. After ingeniously modifying the structure of 3-amino-2-bromo-5-fluoropyridine, the drug can accurately act on specific targets of pathogens, prevent their growth and reproduction, and achieve antibacterial effect. In the research and development of anti-cancer drugs, it can participate in the construction of molecular structures with special activities, which can help drugs interfere with the division and signal transduction of cancer cells, opening up new paths for the creation of anti-cancer drugs.
Second, in the field of materials science, it also has extraordinary performance. In the preparation of organic optoelectronic materials, it may be used as a building unit. Organic optoelectronic materials need to have specific optoelectronic properties, such as good charge transport ability and luminescence properties. 3-Amino-2-bromo-5-fluoropyridine atoms such as fluorine and bromine can adjust the electron cloud distribution of the material, thereby optimizing its optoelectronic properties. The materials made on this basis can be used for organic Light Emitting Diodes (OLEDs) to improve the image quality and color of display devices; or for solar cells to improve the photoelectric conversion efficiency and make solar energy utilization more efficient.
Third, in the field of pesticide chemistry, it is also indispensable. Can be used as raw materials for the synthesis of new pesticides. Due to the diverse physiological structures and defense mechanisms of pests, pesticides with unique modes of action are required. 3-Amino-2-bromo-5-fluoropyridine can be chemically synthesized and transformed to produce a pesticide with high toxicity to specific pests, which is relatively friendly to the environment and has little residue. It can effectively prevent and control pests and reduce the adverse impact on the ecological environment.

The synthesis method of 3-amino-2-bromo-5-fluoropyridine is quite complicated, and the following common numbers are listed.
First, 2-bromo-5-fluoropyridine is used as the starting material, and 2-bromo-3-nitro-5-fluoropyridine is obtained by nitration reaction. In this step, a suitable nitrifying agent, such as mixed acid (a mixture of nitric acid and sulfuric acid), is selected to control the reaction temperature, time and other conditions, so that the nitro group can be precisely introduced into a specific position. Then, the nitro group is reduced to an amino group, and the common reducing agents are iron filings and hydrochloric acid, hydrogen and catalysts (such as palladium carbon). Taking hydrogen and palladium carbon as an example, in a suitable reaction vessel, hydrogen is passed through, temperature and pressure are adjusted, and nitro is reduced to amino groups, and finally 3-amino-2-bromo-5-fluoropyridine is obtained.
Second, the amino group can be protected from 2-amino-5-fluoropyridine to prevent it from participating in the subsequent reaction without reason. Commonly used protective groups such as tert-butoxycarbonyl (Boc), etc. After protection, through bromination reaction, using N-bromosuccinimide (NBS) as brominating reagent, under appropriate solvent and reaction conditions, bromine atoms are introduced into the designated position to obtain protected 3-amino-2-bromo-5-fluoropyridine, and finally the protective group is removed to obtain the target product.
Third, bromine atoms can also be introduced by halogenation reaction starting from 3-amino-5-fluoropyridine. Select suitable halogenating reagents, such as liquid bromine, copper bromide, etc., in a suitable reaction environment, so that bromine atoms are successfully connected to the corresponding positions, and then 3-amino-2-bromo-5-fluoropyridine is prepared.
The above methods have their own advantages and disadvantages. In actual synthesis, it is necessary to carefully choose the appropriate method according to the availability of raw materials, cost, reaction conditions and product purity requirements.

3-Amino-2-bromo-5-fluoropyridine is a kind of organic compound. Its physical properties are particularly important, which is related to its performance in various chemical reactions and practical applications.
Looking at its properties, under normal temperature and pressure, it is mostly in a solid state, which is caused by intermolecular forces. The determination of its melting point and boiling point is the key to grasp its thermal stability and phase state transition. The melting point, or due to the regularity of the molecular structure and the strength of intermolecular interactions, falls within a specific temperature range. In this compound, the introduction of bromine and fluorine atoms adds new factors to the intermolecular forces, or the melting point is increased. The boiling point of
is also an important property, reflecting the ease of transition between gaseous and liquid states. Its molecular polarity is apparent due to the presence of amino groups, bromine atoms and fluorine atoms. In addition to van der Waals forces, there is still a strong dipole-dipole force between polar molecules, which may increase the boiling point.
In terms of solubility, due to the presence of polar groups, it may have some solubility in polar solvents such as alcohols and water (partially soluble). However, due to the hydrophobicity of pyridine rings, it has poor solubility in non-polar solvents such as alkanes.
In addition, the color state of 3-amino-2-bromo-5-fluoropyridine, or white to yellowish solid, is related to intramolecular electron transitions and conjugated systems. Its density, which is affected by molecular mass and molecular stacking mode, can be used to consider the parameters of its behavior in solution.
In summary, the physical properties of 3-amino-2-bromo-5-fluoropyridine, such as melting point, boiling point, solubility, color state and density, are determined by its molecular structure and play a key role in chemical synthesis, materials science and other fields.

The market price of 3-amino-2-bromo-5-fluoropyridine is difficult to determine directly. This compound has various uses in chemical, pharmaceutical and other fields, and its price is also affected by multiple factors.
The first to bear the brunt is the cost of raw materials. If the starting materials required for the synthesis of this pyridine derivative are scarce, difficult to obtain, or complicated to prepare, the price will be high, which will then push up the price of the finished product.
Furthermore, the preparation process has a great impact. The process is simple and efficient, and the cost can be reduced; however, if the process is lengthy and the conditions are harsh, and special equipment or reagents are required, the cost will increase greatly, and the price will also rise.
The market supply and demand situation is also the key. If many companies are in urgent demand for this product and the supply is limited, the price will often rise; on the contrary, if the supply exceeds the demand, the price will have downward pressure.
Product purity is also an important factor. High-purity 3-amino-2-bromo-5-fluoropyridine is difficult to prepare, expensive, and sells at a higher price than low-purity ones.
In addition, market competition, transportation costs, storage conditions and other factors will affect its price. To know the exact price, consult the relevant chemical raw material suppliers and distributors in detail, or compare it with multiple parties on the chemical product trading platform to obtain more accurate market price information.

3-Amino-2-bromo-5-fluoropyridine is an important intermediate in organic synthesis. During storage and transportation, several matters must not be ignored.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Cover it is quite sensitive to moisture and heat, and if it is in a high temperature and humid place, it may deteriorate. And it must be kept away from fires and heat sources to prevent fires. It should be stored in a sealed container to prevent oxidation in contact with air. At the same time, it should be stored separately from oxidizing agents, acids, bases, etc. Because of contact with it, it is easy to cause chemical reactions and damage its quality.
As for transportation, there are also many points to pay attention to. It is necessary to ensure that the packaging is complete and sealed to prevent its leakage. During transportation, avoid violent vibration and impact to prevent damage to the container. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment to be prepared. And when transporting, you should follow the specified route and do not stop in densely populated areas or residential areas.
These precautions are related to the quality and safety of 3-amino-2-bromo-5-fluoropyridine. Workers engaged in related work must follow them carefully and must not be negligent to avoid harm.