3-Amino-2,6-dichloropyridine-4-carboxylic acid methyl ester

3-Amino-2,6-dichloropyridine-4-carboxylic acid methyl ester, this is an organic compound. It has a wide range of uses and has important applications in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate for the synthesis of drug molecules with specific biological activities. Due to its unique chemical structure, it can participate in a variety of chemical reactions to build complex drug frameworks. For example, it can be used to react with other compounds containing specific functional groups, such as nucleophilic substitution, condensation, etc., to prepare new drugs with antibacterial, antiviral or antitumor activities.
In the field of pesticide chemistry, it also plays a significant role. Or it can undergo a series of chemical transformations to obtain high-efficiency pesticides. For example, by modifying its structure, it can enhance the pertinence and lethality to specific pests or bacteria, providing strong support for agricultural pest control.
In addition, in the field of materials science, there is also potential application value. Its unique structure or endow materials with special properties, such as participating in the preparation of new materials with specific optical, electrical or mechanical properties, injecting new vitality into the development of materials science.
In summary, 3-amino-2,6-dichloropyridine-4-carboxylic acid methyl ester has key uses in many fields such as medicine, pesticides and materials science, and is of great significance to promote the progress and development of various fields.

The synthesis method of methyl 3-amino-2,6-dichloropyridine-4-carboxylic acid is a key research direction in the field of organic synthesis. Its synthesis path is diverse, each has its advantages and disadvantages, and chemists need to weigh the choice according to the actual situation.
First, it can be started from 2,6-dichloropyridine-4-carboxylic acid. First, the esterification reaction is carried out with a suitable alcohol under acid-catalyzed conditions to obtain 2,6-dichloropyridine-4-carboxylic acid ester. In this step, the common alcohol is methanol, and the acid catalyst is concentrated sulfuric acid, p-toluenesulfonic acid, etc. Subsequently, the ester is aminated. Suitable amination reagents can be selected, such as ammonia gas, amine compounds, etc. Under suitable reaction conditions, the ortho or meta-position of the ester group can be introduced into the amino group to obtain the final target product. The advantage of this path is that the starting material is relatively easy to obtain, and the esterification and amination reactions are both classic organic reactions, and the operation is relatively mature. However, the disadvantages are also obvious. For example, there may be selectivity problems in the amination step, and it is easy to generate by-products, which affects the yield and purity.
Second, 2,6-dichloro-4-halopyridine is used as the raw material. First, through the nucleophilic substitution reaction, the halogen atom is replaced with a carboxyl group with a suitable carboxylation reagent, such as carboxylate, etc., and then the esterification reaction is carried out to generate 2,6-dichloropyridine-4-carboxylic acid methyl ester. Finally, the amination reaction is carried out to introduce amino groups. The advantage of this route is that the nucleophilic substitution reaction has good selectivity and can precisely control the reaction check point; however, the preparation of the starting material 2,6-dichloro-4-halo pyridine requires multiple steps and the cost is relatively high.
Third, the strategy of building a pyridine ring is adopted. 3-Amino-2,6-dichloropyridine-4-carboxylic acid methyl ester can be directly formed by cyclization reaction with suitable nitrogen, chlorine and carboxyl precursors. This method can theoretically construct the target molecular skeleton in one step, and the steps are simple; however, the cyclization reaction conditions are harsh, the reaction equipment and operation requirements are high, and the reaction mechanism is complex, which is difficult to precisely regulate.

3-Amino-2,6-dichloropyridine-4-carboxylic acid methyl ester, this is an organic compound with unique physical and chemical properties, which is worthy of careful investigation.
Looking at its physical properties, under normal conditions, it may be a white to light yellow solid with a certain crystalline form. In terms of melting point, according to relevant chemical studies, it is often in a specific temperature range. This temperature is of great significance to its physical state transition and is related to its existence in different environments.
In terms of solubility, it shows certain solubility in organic solvents, such as common ethanol, acetone, etc. This property is derived from the interaction between molecular structure and solvent molecules, such as van der Waals force, hydrogen bonding, etc. In water, its solubility is relatively limited, which is due to the degree of adaptation between the molecular polarity of the compound and the polarity of the water molecule.
In terms of chemical properties, the presence of amino groups gives it a certain alkalinity, which can neutralize with acids to form corresponding salts. This reaction is of great significance in organic synthesis and can be used to prepare specific derivatives to expand the application range of compounds. 2,6-Dichlorine atoms on the pyridine ring change the density of the ring electron cloud, making the compound prone to nucleophilic substitution reactions. Chlorine atoms can be replaced by a variety of nucleophilic reagents to form new chemical bonds and enrich the organic synthesis path.
Furthermore, the carboxylic acid methyl ester group has the properties of esters, which can undergo hydrolysis reaction under the catalysis of acids or bases to generate corresponding carboxylic acids and alcohols. The hydrolysis reaction conditions are different, the proportion of products and the reaction rate are also different, and the key intermediates can be prepared in the field of organic synthesis and drug development.
In summary, the physicochemical properties of 3-amino-2,6-dichloropyridine-4-carboxylic acid methyl esters lay the foundation for their application in many fields such as organic synthesis and medicinal chemistry, and are indeed an important object of organic chemistry research.

What you are inquiring about is the price range of 3-amino-2,6-dichloropyridine-4-carboxylic acid methyl ester in the market. However, the price of this compound often varies due to many factors, making it difficult to determine directly.
First, the trend of supply and demand has a great impact. If the demand for this product is strong and the supply is scarce, the price will tend to be higher; on the contrary, if the supply is abundant and the demand is small, the price may drop.
Second, the quality is also the key. High-purity, high-quality products, the price is often higher than ordinary ones. Those with fine preparation technology and few impurities have a higher self-worth.
Third, the amount purchased is related to the price. For bulk purchases, merchants may give discounts due to large quantities, and the unit price may be low; for sporadic purchases, the unit price may be high.
Fourth, the state of market competition also affects the price. There are many suppliers in the market, and the competition is fierce. In order to compete for share, there may be price reductions; on the contrary, if there are few suppliers and the competition is weak, the price may be strong.
According to past market conditions, the price of this compound may range from tens of yuan to 100 yuan per gram when purchased in small quantities; if purchased in bulk, such as kilograms, the price per kilogram may be around several thousand yuan. However, this is only an approximate number. The actual price should depend on the current market conditions. It is necessary to consult the supplier in detail to determine its exact price range.

3-Amino-2,6-dichloropyridine-4-carboxylic acid methyl ester, the manufacturer of this product, I have investigated it in detail today. This compound has a wide range of uses in the chemical and pharmaceutical fields, and is related to the preparation of a variety of fine chemicals.
After many inquiries, many well-known chemical reagent suppliers may be involved in the production of such compounds. Among them, Sigma-Aldrich is famous for providing a wide range of chemical reagents, and its product line may contain this substance. The company has a long-standing reputation in the global chemical reagent market. The reagents it produces are of high quality and strictly tested, and are widely trusted by scientific research and industrial users.
Another example is Alfa Aesar, which is also a leader in the chemical field. It specializes in the research and development and production of high-end chemical reagents, and has considerable attainments in the preparation of compounds with special structures and high purity. Methyl 3-amino-2,6-dichloropyridine-4-carboxylate may be in its product directory.
There are also many domestic manufacturers involved in such products. For example, Buckingway Technology Co., Ltd. has long been committed to providing high-quality chemical products for scientific research and industrial customers. With its strong R & D and capacity, it actively expands its product line, 3-amino-2,6-dichloropyridine-4-carboxylate or one of its key products.
In addition, Tixi Ai (Shanghai) Chemical Industry Development Co., Ltd., as a professional chemical supplier, relies on the technical advantages of the head office to provide a variety of high-quality chemical reagents in the domestic market. This compound may be within its scope of supply.
However, there are many manufacturers in the market, and the product quality is uneven. When purchasing, it is necessary to carefully review the manufacturer's qualifications, product specifications and customer evaluations to ensure that the purchased goods meet the needs.