(3,5-Difluoropyridine-4-yl)boronic acid

(3,5-Dienyne-4-yl) boric acid has a wide and important application in the field of organic synthesis. The following is a detailed description of its main application fields:
First, in the carbon-carbon bond formation reaction, this boric acid performs well. In the Suzuki-Miyapura reaction, it can efficiently couple with halogenated aromatics or olefins in the presence of palladium catalysts and bases to form new carbon-carbon bonds. This reaction is extremely critical. For example, in the synthesis of polycyclic aromatic hydrocarbons with specific structures, by carefully selecting suitable halogenated aromatic hydrocarbons and (3,5-dienyne-4-yl) boric acids, complex carbon skeleton structures can be precisely constructed. It is often used to construct molecular structures with specific activities or properties in medicinal chemistry and materials science.
Second, (3,5-dienyne-4-yl) boric acid also performs well in the construction of carbon-heteroatomic bonds. It can react with electrophilic reagents containing heteroatoms such as nitrogen, oxygen, and sulfur to generate carbon-heteroatomic bonds. In the synthesis of some nitrogen-containing heterocyclic compounds, the boric acid can be combined with suitable nitrogen-containing electrophilic reagents, providing an effective way to construct bioactive nitrogen-containing compounds. In the research and development of pesticides and medicine, it is helpful to create novel active molecules.
Third, in the field of materials science, this boric acid has a wide range of uses. By participating in the polymerization reaction, polymer materials with special optical and electrical properties can be prepared. For example, when preparing conjugated polymers, the introduction of (3,5-dienyne-4-yl) boric acid into the polymer backbone can change the electronic structure of the polymer, thereby regulating its photoelectric properties, and is used in the preparation of organic Light Emitting Diodes, solar cells and other optoelectronic devices.
Fourth, in the field of total synthesis of natural products, (3,5-dienyne-4-yl) boric acid is an important tool. The structure of natural products is complex, and total synthesis is extremely challenging. With its unique reactivity, the boric acid can participate in the construction of key carbon-carbon bonds and carbon-heteroatomic bonds, helping to realize the total synthesis of natural products, laying the foundation for the study of the biological activity of natural products and the development of related drugs.

The synthesis method of (3,5-dienyne-4-based) boric acid, although the classic "Tiangong Kaiwu" does not describe the synthesis of this specific compound in detail, it contains a lot of chemical process wisdom, which can be used for reference.
To synthesize this compound, one can consider using a halogen containing 3,5-dienyne-4-based as the starting material. First take an appropriate amount of halogen and place it in a clean reactor. The kettle needs to be fired with clay, which can withstand a certain temperature and does not interfere with the reactants. Add an appropriate amount of magnesium chips. The magnesium chips need to be pure in texture and resemble silver chips. The two react in an anhydrous ether solvent. Ether solvents are preferably refined ether, which has a suitable boiling point and stable properties. When stirring, slowly stir with a stick made of mahogany to make it fully contact, and Grignard's reagent can be obtained in this step. During the reaction, the outside of the kettle should be heated with charcoal heat, and the heat should be stable, so as not to cause the decomposition of the reactants to be too strong. When Grignard's reagent is complete, slowly add borate esters. The preparation of borate esters also needs to be fine, and an appropriate amount of boron source should be taken to make esters by a specific process. The speed of dropwise addition should be slow, just like the moisturizing of spring rain, so that the reaction is complete. Then, through the step of hydrolysis, hydrolysis with mild acid can obtain (3,5-dialkenyl-4-yl) boric acid. < Br >
Second, it can be started from olefins containing corresponding groups. Choose high-quality olefins and place them in a glass-made container, which should be clear and transparent to facilitate observation of the reaction process. Add an appropriate amount of borohydride reagent, which should be carefully prepared. The reaction is carried out at a suitable temperature, and the temperature control can be compared to being measured. It is not appropriate to be too high or too low. After the borohydride reaction is completed, go through an appropriate oxidation step. When oxidizing, choose a mild oxidizing agent, such as hydrogen peroxide, and control its dosage. Oxidation is completed, and then through the purification process, the ancient distillation, crystallization and other means to remove its impurities, and finally obtain pure (3,5-dienyne-4-yl) boric acid.

What is the price of (3,5-divinylpyridine-4-yl) boric acid in the market? This is related to the price of chemical materials, and the determination of its price often depends on various reasons.
First, the price of raw materials is the main factor. If the starting material used in the synthesis of this boric acid is rare in source, difficult to collect and complex, the cost will be high, and then the price of this boric acid will be pushed up. If the special pyridine derivatives and boron-containing reagents required for preparation are rare in the market, they need to be specially made or purchased from afar, and their price will rise.
Second, the preparation method also affects its price. If the method requires exquisite equipment, severe reaction conditions, such as high temperature, high pressure, and high purity environment, and the steps are complicated, it requires multi-step reaction and fine separation and purification, which costs a lot of manpower and material resources, and its price is also high. Fine organic synthesis, the yield and purity of each step are related to cost. If the technology is not refined, the yield is low, and there are many impurities, the cost will increase greatly, and the price will also rise.
Third, the supply and demand of the market is also the key. If this boric acid is widely needed in the electronics, pharmaceutical and other industries, and it is used to make new electronic materials and special drugs, but the supply is small, and the supply is in short supply, the price will increase. On the contrary, if the market is saturated and the demand is weak, the price may drop.
Fourth, the scale and production efficiency of the manufacturer also affect the price. Large factories may reduce the cost per unit product due to the scale effect. However, if small factories do not have efficient production processes, the cost is difficult to control, and the price may be high.
Overall, the market price of (3,5-divinylpyridine-4-yl) boric acid varies depending on raw materials, production methods, supply and demand, and manufacturers, ranging from hundreds of yuan per gram to thousands of yuan per gram. In actual transactions, when various factors are carefully observed, the price can be determined.

What are the physical and chemical properties of (3,5-diolefin-4-yl) boric acid? The following is a classical Chinese format to solve this problem.
(3,5-diolefin-4-yl) boric acid, which is one of the organoboron compounds. In terms of physical properties, under normal circumstances, it is mostly in a solid state. Due to the existence of various forces between molecules, it has a certain condensed state. Looking at its color, it is often white or off-white, with a pure and uniform appearance. The value of its melting point, based on fine measurement, is within a specific range. This melting point is the inherent physical constant of the substance, determined by its molecular structure and intermolecular interactions.
As for solubility, in organic solvents, such as ethanol, ether, etc., there is a certain solubility. This is because the boric acid molecule can form specific interactions with organic solvent molecules, such as van der Waals force, hydrogen bonds, etc., so it can be partially miscible. However, in water, its solubility is relatively limited, because the hydrophobic part of the molecule affects its affinity with water molecules.
In terms of its chemical properties, (3,5-diolefin-4-yl) boric acid has typical boric acid properties. Boric acid is a weak acid, and this compound is also acidic. Although acidic, it can neutralize with bases to form corresponding borates. The carbon-carbon double bond in its structure gives it the typical reactivity of olefins. It can participate in addition reactions, such as addition with halogens, hydrogen halides, etc., to open the double bond and form new compounds. And the compound can be used as an important intermediate in organic synthesis, playing a key role in the construction of complex organic molecular structures. By reacting with other organic reagents, the formation of carbon-carbon bonds and the transformation of functional groups can be achieved.

During the storage and transportation of (3,5-divinylpyridine-4-yl) boric acid, the following numbers should be paid attention to:
First, moisture resistance is essential. This boric acid has a certain hydrophilicity, and if exposed to humid air, it is easy to absorb moisture and deteriorate. The ancients said: "Wet things are easy to perish and damage." Moisture invades it, or causes its structure to change, affecting its chemical activity. Therefore, it should be stored in a dry place, and the packaging must be tightly sealed, and a desiccant can be used to assist in maintaining a dry environment.
Second, the temperature also needs to be carefully controlled. Excessive temperature may cause it to decompose, and too low temperature may affect its stability. The so-called "The existence of things also requires appropriate temperature to nourish them". In general, it is recommended to store in a cool place, and avoid high temperature environments when transporting. For example, during summer transportation, cooling measures need to be taken.
Third, anti-oxidation cannot be ignored. Some groups in this boric acid are easily oxidized, just like "steel is easy to rust in the gas". During storage, inert gas can be filled to isolate oxygen, and the transportation process should also ensure that the packaging can effectively block oxygen intrusion.
Fourth, avoid contact with incompatible substances. This boric acid will react with some acids, bases and oxidizing agents, "each has its own characteristics, and each phase will be messy". During storage and transportation, it must not be mixed with these substances. Be sure to store and transport them in categories to prevent unexpected reactions.