3,5-Dibromo-4-cyanopyridine

3,5-Dibromo-4-hydroxyacetophenone is a key intermediate in the field of organic synthesis. Its main uses are quite extensive, and are described as follows:
One, in the field of pharmaceutical synthesis, this compound occupies a pivotal position. Due to its structural characteristics, it can be used as a key raw material for the preparation of a variety of drugs. For example, in the synthesis process of some antibacterial drugs, 3,5-dibromo-4-hydroxyacetophenone can participate in complex chemical reaction steps by virtue of its bromine atom and hydroxyl group activity. After a series of ingenious transformations, a drug molecular structure with antibacterial activity is finally constructed, which is effective in treating diseases caused by specific bacteria.
Furthermore, in the field of pesticides, 3,5-dibromo-4-hydroxyacetophenone is also very useful. With its unique chemical properties, many high-efficiency pesticide products can be developed. For example, the creation of some pesticides, the compound can be used as a starting material, and through careful reaction with other reagents, it can be synthesized with strong pest resistance and environmental friendliness. It contributes to the protection of crops from insect infestation and the realization of agricultural harvest.
All three, in the field of materials science, this substance also shows unique value. Because of the functional groups contained in its structure, it can participate in the synthesis reaction of specific materials, thereby improving the properties of materials. For example, the introduction of 3,5-dibromo-4-hydroxyacetophenone in the preparation of some polymer materials can endow the materials with special properties such as better thermal stability and optical properties, broaden the application range of the materials, and meet the needs of different fields for special materials.
In summary, 3,5-dibromo-4-hydroxyacetophenone, with its unique chemical structure and reactivity, plays an indispensable role in many fields such as medicine, pesticides and materials science, and is of great significance to promote the development of related industries.

The synthesis method of 3,5-dibromo-4-hydroxyacetophenone is a crucial issue in the field of organic synthesis. There are many ways to study in this synthesis.
First, resorcinol is used as the starting material. First, resorcinol and acetyl chloride are acylated by Fu-Ke in the presence of a suitable catalyst. This reaction requires precise temperature control and suitable solvent selection to effectively combine the phenolic hydroxyl group of resorcinol with the acyl group of acetyl chloride to generate 4-hydroxyacetophenone. Subsequently, 4-hydroxyacetophenone is reacted with bromine under specific reaction conditions. The amount of bromine, reaction temperature and time are all key factors. Properly controlled, bromine atoms can selectively replace the hydrogen atoms at the 3,5-position on the benzene ring to obtain 3,5-dibromo-4-hydroxyacetophenone.
Second, the method of using p-hydroxybenzoic acid as the starting material. First, the p-hydroxybenzoate is esterified to obtain p-hydroxybenzoate. This step requires the selection of suitable alcohol and catalyst to promote the esterification reaction to proceed smoothly. After that, the resulting ester is subjected to Clemson reduction reaction, using zinc amalgam and concentrated hydrochloric acid as reagents, the ester group is reduced to methyl to obtain 4-hydroxyacetophenone. The synthesis of 3,5-dibromo-4-hydroxyacetophenone was achieved by the reaction of 4-hydroxyacetophenone with bromine as described above.
Third, phenol can also be considered as the starting material. Phenol is first acetylated to form phenyl acetate. Under the catalysis of Lewis acid, phenyl acetate undergoes a Frith rearrangement reaction to obtain a mixture of o-hydroxyacetophenone and p-hydroxyacetophenone. After separation and purification, 4-hydroxyacetophenone is obtained, and then reacts with bromine to achieve the preparation of 3,5-dibromo-4-hydroxyacetophenone.
All synthetic methods have their own advantages and disadvantages. The cost of raw materials, reaction conditions, purity and yield of the product are all important considerations. When synthesizing, it is necessary to carefully choose the appropriate method according to the actual needs and conditions, so as to achieve the synthesis goal of high efficiency, economy and environmental protection.

What is the market price of 3% 2C5-dibromo-4-hydroxyacetophenone today? This question is quite difficult, because the market price is often changed over time, and is affected by many factors, such as origin, quality, supply and demand conditions.
However, if you want to know the price roughly, you can observe the common situation of market trading. In the market of chemical raw materials, the price of these compounds may vary depending on the quantity. If the amount purchased is small, it is only needed for the experiment, and the price is high, which covers the preparation of the product, and requires fine methods to maintain purity.
If you buy a large amount, such as for industrial use, the price may be slightly reduced. According to the usual theory, the price of the product with high purity must be higher than that of the product with low purity. Also, the distance of the place of origin is also related to the price. If it is close to the place of origin, the freight will be saved, and the price may be slightly flat; if it is far away, the freight will be added, and the price will increase.
And the situation of supply and demand is particularly affected. If there are many people who want it, but there are few suppliers, the price will rise; on the contrary, if the market is saturated, the supply will exceed the demand, and the price may decline. Therefore, if you want to know the exact price, you need to check the market situation carefully and consult the merchants of chemical raw materials, or you can get a recent price.

3,5-Dibromo-4-hydroxyacetophenone must be carefully stored and transported.
It is active and should be stored in the first environment. It should be placed in a cool, dry and well-ventilated place, away from open flames and hot topics. Because it is easy to react or cause danger when heated. If stored in a damp place, it is easy to be eroded by water vapor and cause quality deterioration. And should be stored separately from oxidants and alkalis, and should not be mixed with each other to prevent the interaction from causing harm.
When handling, be sure to handle it with care, because its texture is delicate and brittle. If it is violently shaken or hit, it may cause damage to the package and material leakage. Once leaked, not only the material is damaged, but also the surrounding environment and personal safety are endangered. Those involved in handling should be equipped with protective equipment, such as protective clothing, gloves and goggles, to prevent the material from coming into contact with the skin and eyes.
During transportation, choose a safe transportation tool to ensure that the packaging is intact and the loading is stable. Traffic route planning also needs to be careful to avoid crowded and important areas. Transportation vehicles should be equipped with corresponding emergency treatment equipment and protective equipment for emergencies. Transportation personnel should also be familiar with material characteristics and emergency response methods, and inspect frequently on the way. If there is any abnormality, take measures quickly.
In short, the survival and transportation process of 3,5-dibromo-4-hydroxyacetophenone involves safety and quality, and must not be slack and negligent.

3,5-Dibromo-4-hydroxyacetophenone, this material has unique physical and chemical properties. Its physical properties are solid at room temperature, and it may be white to light yellow crystalline powder. The melting and boiling point is very critical. The melting point is about 108-112 ° C. At this temperature, the solid phase will gradually melt into the liquid phase, and the boiling point is difficult to determine due to the lack of relevant data. It has good solubility in organic solvents, such as ethanol, ether, etc., and can be miscible with these solvents. In water, it has poor solubility. Because of its molecular structure, there are few hydrophilic groups, and the hydrophobic part accounts for a large proportion.
In terms of its chemical properties, bromine atoms in this substance are quite active. The electron cloud density of bromine atoms is high, which is vulnerable to attack by nucleophiles, and nucleophilic substitution reactions can occur. If it reacts with alcohols under basic conditions, bromine atoms can be replaced by alkoxy groups to form corresponding ether compounds. Hydroxyl groups are also active and can participate in esterification reactions. Under acid catalysis, they can react with carboxylic acids to form esters. This reaction is reversible, and the water generated by the reaction needs to be removed to promote the positive progress of the reaction. In addition, the presence of the benzene ring gives it aromatic properties, and electrophilic substitution reactions can occur. If it reacts with halogenating agents under appropriate conditions, other halogen atoms can be introduced into the benzene ring. Due to the presence of both bromine atoms and hydroxyl groups in its structure, a certain group can selectively participate in the reaction under different reaction conditions, providing many possible paths for organic synthesis. It is widely used in pharmaceutical chemistry, materials science, and other fields, and is often used as a key intermediate in organic synthesis.