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What are the main uses of 3,4-pyridinedicarboxylic acid?
3,4-Pentadienedioic acid, its main uses are as follows:
First, in the field of organic synthesis, this is a key intermediate. It can interact with many reagents through a series of chemical reactions to form more complex organic compounds. For example, under specific catalytic conditions, it can undergo addition reactions with compounds containing active hydrogen, and then introduce new functional groups, laying the foundation for the synthesis of substances with specific biological activities or material properties.
Second, in the field of materials science, it has the potential to participate in polymerization reactions. If it is introduced into the structure of polymeric polymers, due to the double bonds and carboxyl groups in the molecule, it may endow the polymer with unique physical and chemical properties, such as changing the flexibility, thermal stability and mechanical properties of the polymer. By carefully regulating the conditions and proportions of the polymerization reaction, it is expected to prepare high-performance materials that meet different application requirements, such as in the preparation of some special coating materials or engineering plastics.
Third, in the field of medicinal chemistry, its structural properties make it possible to modify and optimize as a lead compound. Because of its carboxyl and double bond structures, it may interact specifically with targets in organisms. Scientists can carry out structural modification based on this to improve its affinity and selectivity with targets, so as to develop drugs with novel mechanisms of action for the treatment and prevention of diseases.
In summary, 3,4-pentadienedioic acid has shown important uses in many fields such as organic synthesis, materials science and medicinal chemistry due to its unique molecular structure, which is of great significance for promoting the development of related fields.
What are the physical properties of 3,4-pyridinedicarboxylic acid?
The physical characteristics of 3,4-diaminodibenzoic acid are quite specific. Looking at its shape, at room temperature, it is often in the shape of a solid state, or a powder, or a crystalline shape, delicate and regular, with a smooth crystal surface, reflecting shimmering light, as if the stars are falling.
When it comes to color, it is mostly white to light yellow. Those who are white are like the first fall of winter snow, and those who are light yellow are like the morning light, pure but soft.
Smell it, it is almost odorless, like a hidden person in the world, silent and unnoticeable.
Its density is also a specific value, and it has its own unique sense of weight when placed in objects. However, this density cannot be perceived at will, and it needs to be measured with exquisite instruments and rigorous methods.
Furthermore, the melting point is its important physical property. When it reaches a specific temperature, this object gradually melts from the solid state, just like ice and snow meet the warm sun and turn into a babbling liquid. This melting point temperature is its inherent characteristic, which can be used to identify this object.
In terms of solubility, it is slightly soluble in water. Water is the source of life and the solvent of all things. However, 3,4-diaminodibenzoic acid is only slightly soluble here, and seems to maintain a subtle distance from water. In organic solvents, such as ethanol and acetone, their solubility may be different, or it may be slightly easier to dissolve, or there are still obstacles, all of which are determined by the structure and properties of their molecules.
The various physical properties are the key to understanding 3,4-diaminodibenzoic acid, which is like a key, which can open the door to understanding this material, and it can be used in many fields such as chemical industry and medicine. It also depends on the detailed investigation of the rational characteristics of this material.
What are the chemical properties of 3,4-pyridinedicarboxylic acid?
For 3,4-dimethyladipic acid, there is a chemical reaction. It is acidic, and the molecule contains a dicarboxyl group, which can cause a neutralization reaction. If it is oxidized, it will form a phase of water. This is the generality of the carboxyl group.
also has the ability of esterification. Under acid catalysis and addition of alcohol, its carboxyl group can be reacted to the alcohol group and the raw ester water. For example, ethanol can be reacted, and the ester of the phase can be obtained. This reaction is reversible. In order to make the reaction move to the direction of ester formation, it is often necessary to remove the generated water or increase the resistance of the reaction.
In terms of its physical properties, it is generally solid, and the melting is special. This is due to the action of the molecule and the van der force. It has a certain solubility in water, but the solubility is not high, and the alkyl group part in the molecule is hydrophobic, while the carboxyl group can form alkyl in water, but the alkyl group part limits its solubility.
In the field of synthesis, 3,4-dimethyladipic acid can be used as a raw material for more complex compounds. Its carboxyl group can be polymorphized, and different functionalities can be introduced to expand the scope of its derived compounds to meet different chemical needs.
What are the preparation methods of 3,4-pyridinedicarboxylic acid?
There are various ways to prepare 3,4-diaminobenzoic acid. Let me tell you one by one.
First, phthalic anhydride can be prepared from phthalic anhydride. First, phthalic anhydride is co-heated with ammonia water to obtain o-carboxybenzamide. In this step, the temperature should be properly controlled, and the product should not be decomposed due to excessive temperature. Then the o-carboxybenzamide is reacted with sodium hypochlorite solution and rearranged by Hoffman to obtain o-aminobenzoic acid. Then, using o-aminobenzoic acid as raw material, through nitration reaction, under specific conditions, the nitro group is selectively introduced into the para-position of the amino group to obtain 3-nitro-4-aminobenzoic acid. Finally, iron powder and hydrochloric acid are used as reducing agents to reduce the nitro group to an amino group, resulting in 3,4-diaminobenzoic acid.
Second, benzoic acid can also be used as the starting material. Benzoic acid is first nitrated to obtain m-nitrobenzoic acid. Then the nitro group is reduced with iron powder and hydrochloric acid to obtain m-aminobenzoic acid. M-aminobenzoic acid is then diazotized and Sandmeier reacted to introduce bromine atoms to obtain 3-bromo-4-aminobenzoic acid. Finally, through an aminolysis reaction, liquid ammonia and sodium metal are used as reagents to replace bromine atoms with amino groups to obtain 3,4-diaminobenzoic acid.
Third, p-nitrobenzoic acid can also be started. p-Nitrobenzoic acid first reduces the nitro group to an amino group to obtain p-aminobenzoic acid. P-aminobenzoic acid is acetylated to protect the amino group, and then nitrification is carried out, so that the nitro group is introduced into the ortho-position of the amino group to obtain 3-nitro-4-acetaminobenzoic acid. Then hydrolyze to remove the acetyl group, and then reduce the nitro group to an amino group, and 3,4-diaminobenzoic acid can also be obtained.
The preparation method has its own advantages and disadvantages, and it needs to be carefully selected according to the actual situation, such as the availability of raw materials, the difficulty of reaction, and the consideration of cost.
What is the price range of 3,4-pyridinedicarboxylic acid in the market?
The price of 3,4-dimethylglutaric acid in the market varies according to its quality and market conditions. Looking at "Tiangong Kaiwu", the price of various ancient things varies according to the supply and demand of time and place, and the same is true for this acid.
In today's market, its price is about a few hundred yuan per kilogram. If the quality is high and pure, it is a fine research grade, and the price may be slightly higher, up to 500 yuan or even 1,000 yuan per kilogram. The cover is difficult to prepare and used in medicine, chemical industry and other industries, requiring refined products.
If it is an industrial grade, the purity requirement is slightly reduced, and the price is slightly lower, between 200 yuan and 500 yuan per kilogram. Its price also varies with the supply and demand of the market. If there are many applicants, but there are few producers, the price will rise; if there is abundant production and less demand, the price will tend to fall. And the price is also affected by factors such as the price of raw materials, the purchase of crafts, taxes and transportation costs. The market is volatile, and the price is also variable. Merchants often adjust their prices according to the changes of time.