3-(3-Pyridine)acrylic acid

3 - (3 - to the other) dogwood acid, covered with various uses, this is the refinement of plants and trees, and its work is also done.
Its main user, the first is to remove filth. The ancient sages believed that dogwood acid was born in the mountains, and it took the righteous qi of heaven and earth, and had a unique fragrance. Every time I go to Chongyang, I wear dogwood and eat dogwood, which can resist the unhealthy qi of the four seasons and prevent evil filth from invading. It is because of the people that every time it is on this festival, dogwood is inserted in the windows of the house, and both men and women wear it.
Furthermore, dogwood acid also has the ability to cure diseases. The doctor said that its nature is warm, the taste is refreshing, and it enters the liver, kidney, and spleen meridians. It can cure cold hernia abdominal pain, it can warm the cold of burnt, and dissipate the cold evil of Jueyin liver meridian, so that qi and blood are unobstructed, the pain is stopped and the body is safe. And in the disease of cold and damp athlete's foot, it also has good effects. With its dry and damp nature, it can remove dampness in the lower limbs, clear collaterals and relieve pain, and make walking as usual.
In addition, dogwood acid also has special functions in seasoning. People make good use of it, and it can increase the flavor of food. Its spicy smell can remove the fishy smell, freshen and increase the fragrance, and make dishes unique. And a small amount of it can appease and strengthen the spleen, increase appetite, and make people eat
In addition, dogwood acid is also beneficial to the mind. Smelling its fragrance can wake up the mind and make the mind comfortable and breathless. When people are tired and bored, smelling the fragrance of dogwood acid is like a breeze blowing on the face, the sleepiness and boredom will disappear, and the body and mind will recover.
In short, the use of 3 - (3 - to it) dogwood acid is related to health, healing, diet, and emotions. It is a wonderful thing. It is indispensable for people's daily use and for doctors to treat diseases.

3- (3-alkynyl) propionic acid, also known as 3- (3-alkynyl) acrylic acid, is an organic compound. Its physical properties are as follows:
In terms of appearance properties, this substance often appears as a colorless to light yellow liquid at room temperature and pressure. In terms of melting point, the melting point is relatively low. The specific value varies depending on the precise measurement conditions, between about -10 ° C and 0 ° C. The boiling point is about 190 ° C to 200 ° C at a certain pressure, but because of its certain heat sensitivity, it may decompose at high temperatures.
In terms of solubility, the substance has good solubility in some organic solvents, such as ethanol, ether, dichloromethane and other common organic solvents. In ethanol, it can miscible with each other in any ratio, which is due to the polar groups contained in its molecular structure and ethanol molecules can form interactions such as hydrogen bonds; in ether, it also has good solubility, which is due to the van der Waals force interaction between molecules. However, its solubility in water is poor. Due to the large proportion of non-polar alkynyl groups in the molecule, the polarity difference between it and water molecules is significant, which violates the principle of "similar miscibility". The density of
is slightly higher than that of water, about 1.1-1.2 g/cm ³, which is closely related to its molecular structure. The carbon atoms in the molecule are connected with other atoms through covalent bonds to form a relatively compact structure, resulting in a unit volume of weight slightly higher than that of water.
Volatility has a certain degree of volatility. In an open system, some substances will evaporate into the air over time, and because of its pungent odor, people can detect it when it evaporates. However, compared with some low-boiling, high-volatility organic solvents, its volatilization rate is relatively slow.
In terms of stability, 3- (3-alkynyl) propionic acid is chemically active, and the alkynyl structure in the molecule gives it high reactivity. During storage and use, care should be taken to avoid contact with strong oxidants, strong acids, strong bases and other substances to prevent violent chemical reactions. And, in view of its sensitivity to heat, it should be stored in a cool, well-ventilated place, away from heat and fire sources to ensure its stability.

3- (3-Hydroxy) butyric acid, also known as β-hydroxybutyric acid, has many chemical properties. It is colorless to light yellow liquid, miscible with water, has certain solubility, and can be partially ionized in water, showing weak acidity.
From a structural point of view, because it contains hydroxyl groups and carboxyl groups, it has two types of functional group characteristics. Hydroxyl groups can cause substitution reactions, such as reacting with hydrogen halides, the hydroxyl group is replaced by halogen atoms; it can also be dehydrated to form alkenes. Under appropriate conditions, the hydroxyl groups and hydrogen atoms on adjacent carbons dehydrate water molecules to form carbon-carbon double bonds.
The presence of carboxyl groups allows them to neutralize with bases to form corresponding carboxylate and water. It can also be esterified with alcohols. Under acid catalysis, the carboxyl group binds to the alcohol hydroxyl group to dehydrate and form ester compounds.
In addition, 3- (3-hydroxy) butyric acid has certain redox properties. Hydroxy groups can be oxidized, and can be oxidized to aldehyde or carboxyl groups depending on conditions; under the action of specific reducing agents, carboxyl groups can also be reduced to alcohol hydroxyl groups. Its chemical properties are active and it is widely used in the field of organic synthesis. It is often used as a raw material for the preparation of various organic compounds with specific structures and functions.

To prepare 3 - (3 - alkynyl) malonic acid, the following methods can be used:
First, diethyl malonate is used as the starting material. First, it reacts with strong bases such as sodium alcohol, and the hydrogen of the active methylene in the diethyl malonate is taken away by the base to generate a carbonegative ion. Then the carbonegative ion meets the halogenated hydrocarbon containing 3 - alkynyl group. According to the mechanism of nucleophilic substitution, the carbonegative ion attacks the carbon attached to the halogen atom of the halogenated hydrocarbon, and the halogen atom leaves to obtain 3 - (3 - alkynyl) diethyl malonate. The product is then co-heated with a dilute acid, hydrolyzed, and the ester group is converted to a carboxyl group to obtain 3- (3-alkynyl) malonic acid. The raw materials are easy to obtain in this way, and the steps are clear. However, the reaction conditions need to be precisely controlled, and the choice of halogenated hydrocarbons may affect the yield.
Second, acetylene is used as a base. First, acetylene reacts with alkali metals (such as sodium metal) to form sodium acetylene. This sodium acetylene has strong nucleophilicity and can interact with halogenated malonate esters. After nucleophilic substitution, malonate derivatives containing alkynyl groups are obtained. Subsequent hydrolysis is also used to change the ester group to a carboxyl group to obtain the target product. This approach cleverly takes advantage of the reactivity of acetylene. However, acetylene needs to be handled with caution. Due to its flammability and explosion, it requires strict reaction equipment and safety measures.
Third, propargyne is used as the starting point. First, propargyne is properly modified, such as introducing suitable functional groups on its alkynyl group, so that it can be reacted with carboxyl-containing synthesizers later. Under the action of suitable catalysts, propargyne and carbon dioxide can be carboxylated to obtain carboxylic acid intermediates containing alkynyl groups. After a series of reactions, such as introducing another carboxyl group with suitable reagents, the final product is 3- (3-alkynyl) malonic acid. This approach is novel, but it requires high catalyst requirements, and the reaction conditions may be more severe, so it needs to be further explored and optimized.

In the city of Wuguan, the price of three - (3 - to it) dogwood oxalic acid often changes with time, and the price varies from place to place. In the past, when it was peaceful in various cities, the price was between tens and hundreds of dollars.
If the weather is smooth and the place is right, and the yield of dogwood oxalic acid is quite abundant, the price may decrease, often around tens of dollars. Everyone can get it, and it is easy for merchants to do this business. However, if there is a natural disaster, the mountains and rivers are out of order, or man-made disasters are disturbed, and farming is difficult to flourish, the yield of dogwood oxalic acid will drop sharply, and the price will rise sharply. Or to hundreds of dollars, even thousands of dollars are rare.
In cities around the world, the ethos is different, and different needs are different. In a prosperous city, there are many rich people, and there are many people who seek dogwood oxalic acid, either for health care or for medicine, and its price is also high. And in remote towns, people rarely know its use, the demand is weak, and the price is low.
There are also merchants' plans, which are also related to their prices. Those who are good at the times change, know the profit and deficiency, and hoard up. If the price is high, they will sell it, and if the price is low, they will receive it. The price often fluctuates because of it.
Generally speaking, the price of dogwood oxalic acid in the market is often between tens of dollars and hundreds of dollars. However, natural disasters and man-made disasters, local supply and demand, and merchants' plans can make the price exceed this range, or as low as a few dollars, or as high as a thousand dollars. It is difficult to determine.