3-(3-nitrophenyl)imidazo[1,5-a]pyridine-1-carbaldehyde

The chemical properties of 3- (3-hydroxymethylfurfural) pyrido [1,5-a] pyrido-1-ethylquinoline, although this substance has no direct corresponding record in "Tiangong Kaiwu", can be inferred from the relevant chemical principles and traditional process records.
First of all, 3- (3-hydroxymethylfurfural) pyrido [1,5-a] pyrido-1-ethylquinoline has a complex structure and contains a variety of functional groups. From the perspective of chemistry, hydroxymethyl groups have the properties of alcohol hydroxyl groups, which can undergo a substitution reaction and can be esterified with acids. For example, in the traditional brewing process, starter fermentation produces acid and alcohol esterification and flavor enhancement. This hydroxymethyl group or similar reaction; in case of strong oxidants, hydroxyl groups are easily oxidized, just like traditional alchemy oxidizes metal minerals, this structural hydroxyl group or the same.
Pyridine ring and quinoline ring are aromatic, relatively stable but electrophilic substitution can occur. Due to the distribution of electron cloud density on the ring, similar to traditional fragrances such as eugenol and other benzene-containing ring structural substances, they can react with electrophilic reagents under appropriate conditions. In addition, the pyridine nitrogen atom is alkaline and can form salts with acids, similar to the neutralization of alkaline plant ash with acids in ancient times. The pyridine nitrogen atom of this substance may form salts with organic acids.
Looking at it as a whole, 3- (3-hydroxymethylfurfurfural) pyrido [1,5-a] pyridine-1-ethylquinoline contains multiple conjugated systems, which may have certain optical properties. Under light or photochemical reactions occur, just like the photochemical phenomena such as the use of sunlight to change the color of certain pigments in ancient times. At the same time, the complex structure makes the intermolecular forces complex, which affects its physical properties, such as melting point and boiling point. By analogy with the temperature control of metal alloys with different melting points boiled in ancient times, understanding their physical properties is meaningful for extracting and separating this substance.

The common synthesis of 3- (3-hydroxypropyl) piperido [1,5-a] pyridine-1-ethylnitrile is a key issue in the field of chemical preparation.
One of the common synthesis methods is obtained by nucleophilic substitution reaction. Under suitable reaction conditions, a compound containing a specific functional group is used as the starting material to interact with the nucleophilic reagent. In this process, the nucleophilic tester attacks specific atoms in the substrate molecule, and then undergoes a substitution reaction to gradually build the structural framework of the target compound. For example, selecting the appropriate halogenated hydrocarbons and nitrogenous nucleophiles can promote the smooth progress of the nucleophilic substitution reaction under the catalysis of bases, thereby introducing the structural fragment of pyrido [1,5-a] pyridine, and then introducing the ethylnitrile part through subsequent reactions.
The second is achieved by cyclization. Using the interaction between functional groups in the molecule, cyclization occurs to construct the core structure of pyrido [1,5-a] pyridine. For example, with a chain-like compound with a suitable functional group as the starting material, under the action of a specific catalyst and reaction conditions, a ring-closing reaction occurs in the molecule to form the desired ring-like structure, and then the substituents on the ring are modified to introduce ethyl nitrile and other groups, thereby obtaining the target product.
The third is the reaction path catalyzed by transition metals. Transition metal catalysts can effectively promote the formation and fracture of various chemical bonds. For example, with the help of transition metal catalysts such as palladium and copper, the coupling reaction between substrate molecules can be catalyzed, and different structural units can be precisely connected to construct the complex structure of 3- (3-hydroxypropyl) piperido [1,5-a] pyridine-1-ethylnitrile. This method has many advantages of mild reaction conditions and high selectivity, and is widely used in modern organic synthesis.
When synthesizing this compound, the most suitable synthesis method should be carefully selected according to the actual situation, considering the availability of raw materials, the difficulty of controlling reaction conditions, yield and selectivity and many other factors.

In "Tiangong Kaiwu", it is said, "Where buckwheat is grown, rice must be mowed in the south, and bushgrass must be mowed in the north. Its nature absorbs a little fertilizer, which can make the soil thin. However, if it is obtained, it will be more than half of the grain, and the family of hard-working farmers will not mind excrement." Buckwheat is found in the north and south, and it is planted after other things are harvested.
As for the application of 3- (3-buckwheat) shochu and [1,5-a] to its-1-methylnaphthalene, according to the records of "Tiangong Kaiwu", although there is no direct related buckwheat shochu and the application of this chemical substance, it can be inferred. Shochu is often necessary in the folk, or as a cold-repelling drink, in rituals, feasts and other occasions. In the field of medicine, it can be used as a medicinal introduction to help the medicinal power to diverge.
And [1,5-a] to its - 1-methylnaphthalene such chemicals, although they have no name in ancient times, they are explored in analogy books for the properties and uses of various substances. If they exist in natural objects, they can be used for dyeing due to physical properties. For example, many plant dyes in the book use their pigment properties; or in tanning and other processes, they use their chemical effects to improve the texture of leather. Although there is no conclusive documentary evidence, it may be useful in the fields of daily use, craftsmanship and so on.

Wen Jun's question is about the market price of tris- (3-carboxylbenzyl) pyridine and [1,5-a] to its -1-ethylquinoline. This matter is related to commercial affairs, and it is necessary to observe the market situation carefully before obtaining a more accurate price.
I heard that "Tiangong Kaiwu" has a saying: "The price of things in the world is not the same, but changes with the rise and fall of the market, and the change of supply and demand." Both of these are chemical substances, and their prices should be controlled by multiple reasons.
First, the price of raw materials. If the raw materials for making these two are rare, or if it is difficult to extract and refine, the cost will be high, and the price will be high. If a rare mineral is used as a raw material, if its mineral source is gradually exhausted, the price will rise, resulting in the cost of the chemical also rising.
Second, the complexity of the process. If the synthesis method is complicated, requires exquisite equipment, superb skills, and there are many losses in the process, it will be labor-intensive and time-consuming, and its price will be high. Just like the ancient method of forging swords, the process is complicated, and the price of the forged swords is comparable to that of extraordinary products.
Third, the supply and demand of the market. If there are many of these two, but there are few producers, the supply is in short supply, and the price will rise; on the contrary, if the supply exceeds the demand, the price will decline. For example, if a drug needs this chemical as a raw material at a certain time, and the number of users increases greatly, the demand for this chemical also increases, and the price rises.
Fourth, the difference between regions. Different places have different prices due to differences in transportation, taxes, etc. Such as remote places, inconvenient transportation, cost increases, and the price may be higher than that of Dayi.
If you want to know the exact market price, you should consult the merchants of chemical raw materials, observe industry reports, or visit professional trading platforms, so that you can get a more accurate price to meet the needs of business.

To know the stability of 3- (3-hydroxypyridine) amide [1,5-a] to its -1-ethylpyrimidine, it can be viewed from the aspects of structure and electronic effects.
Structurally, if 3- (3-hydroxypyridine) amide [1,5-a] is converted to -1-ethylpyrimidine, the molecular framework and atomic connection are greatly changed. In the amide structure, the carbonyl group is connected to the nitrogen atom, which has a certain conjugation effect, so that its structure has a certain stability. In the hydroxypyridine part, the hydroxyl group can form intramolecular or intermolecular hydrogen bonds to further strengthen the structure. When converted to -1-ethylpyrimidine, the original conjugated system interacts with or breaks the hydrogen bond.
In terms of electronic effects, the electron-absorbing effect of amide carbonyl groups reduces the density of the electron cloud of nitrogen atoms. The pyridine ring itself is aromatic, and the presence of nitrogen atoms makes the electron cloud uneven. In the 3 - (3-hydroxypyrimidine) amide [1,5-a] structure, the electronic effects of each part interact, check and balance, and maintain a certain stability. However, after transitioning to -1-ethylpyrimidine, the electron-induced effect of ethyl groups and the unique electron cloud distribution of the pyrimidine ring will change the entire molecular electron cloud state. If the distribution of the newly formed structure electron cloud is more reasonable and stable, the reaction may occur easily, and the product-1-ethylpyrimidine has high stability; conversely, if the distribution of the electron cloud is more unreasonable, resulting in greater tension, the stability will be low.
In addition, the reaction conditions also have a great impact on the stability. Suitable temperature, pH and solvent environment, or to promote the stability of a structure. For example, in an acidic environment, some groups or protonation on the amide or pyrimidine ring changes its electron cloud and stability.
Overall, only from the structural inference, the transition of 3- (3-hydroxypyridine) amide [1,5-a] to -1-ethylpyrimidine requires comprehensive consideration of structural changes, electronic effects and reaction conditions. It is difficult to simply determine its stability. It can only be confirmed by experimental measurement and in-depth theoretical calculation.